@colossal

The de-extinction company.

colossal.com
Joined August 2021
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Breakthrough in dodo de-extinction. Bringing back the dodo is like rebuilding a lost hit from a few scratchy records. The tricky part? The arrangement, aka regulatory DNA. GenoMorph studies living birds to learn how it works. Swipe to learn more. (1/10)
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Getting genetic tools into a bird embryo that’s still developing in the egg is tough. In a new preprint, the Colossal avian team shows lipid nanoparticles can reliably deliver them with high viability.
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📄 Preprint is out now on bioRxiv biorxiv.org/content/10.64898…

High efficiency gene editing and phenotype generation in avian embryos using lipid nanoparticles as...

Birds are a longstanding developmental biology model because easy access to their fertilized eggs allows for direct observation and experimental manipulation during any stage of embryonic growth...

biorxiv.org
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The dodo and the Nicobar pigeon are family. Just with many millions of DNA differences. So which ones gave the dodo that distinct schnoz? Our CSO Dr. Beth Shapiro breaks down how our new software, GenoMorph, helps us find the DNA switches that may have shaped it.
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Colossal Biosciences® retweeted
Bloomberg
@businessOct 19
The biotech firm trying to bring extinct species back to life, Colossal, will return the rare egg of a flightless bird called the moa to New Zealand bloomberg.com/news/articles/…

Biotech Firm Colossal Set to Return Extinct Bird’s Egg to New Zealand

The biotech firm trying to bring extinct species back to life, Colossal Biosciences Inc., has acquired a rare egg of a flightless bird called the moa and will return it to its native New Zealand.

bloomberg.com
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🪵 The trick to making therapy work, is to stick with it
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The dire wolf pups just had their biggest check-up yet. 🐺 CT scans, heart scans, X-rays, bloodwork, even whole-genome sequencing. The verdict? Happy and healthy from snoot to tail. But how big are they? Scroll for the official weigh-in. ⬇️ (1/10)
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One of nature's greatest innovations just got an upgrade🥚 Enter Colossal's Artificial Egg, a key milestone for de-extinction with major implications for conservation in the future. We’ve already hatched 26 healthy chicks using this tech and are closer to bringing back the moa.
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Learn more about why the Artificial Egg made @TIME's Best Inventions of 2026 ⬇️ time.com/collection/best-inv…

Colossal Biosciences Artificial Egg: The Best Inventions of 2026

Find out why Colossal Biosciences Artificial Egg is on TIME's list of 2026's best inventions.

time.com
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Some "normal" people reacting to our latest press release. They had notes. The short version: we're learning from living birds to find DNA switches that may have shaped the dodo's beak and skull, then testing the best leads. Fun? Yes. Going outside? Optional. (1/6)
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