@hopfnerlab

Structural biology on DNA repair, chromatin remodeling and innate immunity.

 Gene Center, Munich, Germany
genzentrum.uni-muenchen.de/research-groups/hopfner/index.html
Joined January 2018
  • Tweets135
  • Following220
  • Followers1.3K
52Media
SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities. Check out our new paper at: nature.com/articles/s41467-0… + movie
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Congratulations to our SLFN team - @Michael_Kug, Felix Metzner and @KatjaLammens for uncovering yet another intricate mechanism! Special thanks to Gregor Witte for his contribution! #innateimmunity #cryoEM #structuralbiology
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hopfnerlab retweeted
IMPRS-ML@IMPRS_ML18 Nov 2024
Upcoming Joint IMPRS Lecture with Karl-Peter Hopfner @hopfnerlab from the @LMU_Muenchen this Thursday, 21 November at 4 pm CET🗓️! The talk is free for everyone, on campus or via Zoom. ↪️More info: imprs-ml.mpg.de/38279/Joint-… @MPI_Biochem @MPIforBI @LMU_Muenchen @TU_Muenchen
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Check out our latest structural paper about human OGG1 processing DNA lesions within nucleosome core particles, in collaboration with Chuanzheng Zhou's lab. #DNArepair #cryoEM nature.com/articles/s41467-0…

Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles

Nature Communications - How DNA glycosylases repair base lesions within nucleosomes remains unclear. Here, the authors determine the cryo-EM structure of 8-oxoguanine-DNA glycosylase 1 bound to an...

nature.com
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Congratulations JP & lab and all co-authors !
JP Lab@JPLab_5 Sep 2024
Excited to share our work showing how PLK1 licenses CENP-A deposition at centromeres to ensure centromere inheritance @WTcell @GeneCenter_LMU @SBSatEd @LMU_Muenchen @Pragya_Sriv @bethan_medina @Alba_Edinburgh @PaulaSoteloP @ERC_Research @wellcome & MRC science.org/doi/10.1126/scie…

PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance

Accurate chromosome segregation requires the attachment of microtubules to centromeres, epigenetically defined by the enrichment of CENP-A nucleosomes. During DNA replication, CENP-A nucleosomes...

science.org
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Alles Gute zum 40. Geburtstag, liebes @GeneCenter_LMU ! 🎉 Hier verbindet sich Grundlagenforschung mit der praktischen #biomedizinischen Anwendung zu exzellenter #wissenschaftlicher Arbeit. Vielen Dank für so viel #Engagement als verlässlicher Partner für den Freistaat #Bayern!
Außenansicht Genzentrum München

ALT Außenansicht Genzentrum München

Wissenschaftsminister Markus Blume mit Ernst-Ludwig Winnacker bei der 40 Jahrfeier des Genzentrums München.

ALT Wissenschaftsminister Markus Blume mit Ernst-Ludwig Winnacker bei der 40 Jahrfeier des Genzentrums München.

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🚀Our celebratory symposium last Monday was enjoyed by all participants😀😆. Bavarian Minister of State Blume and LMU President Huber offered their congratulations. Patrick Cramer, President of the Max Planck Society, sent his greetings via video message.
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The @GeneCenter_LMU celebrates 40 years of groundbreaking #research in the #lifesciences! 🔬🧪In an interview, Director Karl-Peter Hopfner recalls important stages in the center's history and talks about the challenges of the future. lmu.de/en/newsroom/news-over… #GeneCenterMunich

Pacesetter for the life sciences

The Gene Center Munich stands for interdisciplinary top-level research. As the center turns 40, we interview its director Karl-Peter Hopfner, who recalls the most important stages in its history and...

lmu.de
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Just in! Excited to announce our latest paper as a result of great teamwork🔬🧬Thrilled to have collaborated with brilliant minds at @v_hornung's lab, @CarellGroupLMU and @GeneCenter_LMU Huge thanks to @BeroutiMarleen @KatjaLammens for invaluable contributions!
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cell.com/immunity/fulltext/S…

Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7...

TLR7 is critical for recognizing RNA virus infection and initiating antiviral responses. Bérouti et al. demonstrate how RNase T2 and PLD exonucleases generate RNA fragments for TLR7 activation, thus...

cell.com
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Thrilling insights, vibrant discussions, and potent biomedical applications – our two-day @GeneCenter_LMU Retreat at Kloster Irrsee merged science with wonderful companionship. Perfect synergy of innovation and fun! Our lab enjoyed every moment. Huge thanks to GCM! 🧬🔬
lab members at the retreat

ALT lab members at the retreat

check out or new lab logo

ALT check out or new lab logo

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🎉 Horizons 20XX 🎉 Our 40th anniversary lecture series continues on April 15 🥂. We're thrilled to announce that Julia Mahamid will join us, bringing her wealth of experience in structural biology! She'll share insights on: Enabling Discovery by In-Cell Structural Biology🤗
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Check out Michael's talk next Wednesday🧬
Munich RNA Club@MunichRNA7 Mar 2024
In our next meeting #MunichRNA20M, we will hear the amazing RNA science of Yung-Li Chen from @METorresPadilla lab (@Helmholtz_MUC) and @Michael_Kug from @hopfnerlab (@LMU_Muenchen). Hope to see you there! 📅20/03/24 3pm 📍@MPI_Biochem
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Fresh out of the oven, our collaboration with the Kopito Lab - UFL1(E3) modifies, binds to, and dissociates the 60S subunit from the Sec61 translocon! #ribosome #cryoEM
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🥳🥂Our special lecture series to celebrate the 40th anniversary of the Gene Center begins on January 29. We're very excited and looking forward to @kmborgwardt's talk: Machine Learning in Systems Biology: Now and Next Join us as he takes a look into the future of his research🤗
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40 years of science beyond disciplines 🥳In 2024, the @GeneCenter_LMU celebrates 40 years of science beyond disciplines🥂💃🕺 Stay tuned for Horizons 20XX: outstanding scientists will present their work and take a look at the future development of the field
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Many Congratulations to Lab Alumni Carina! We are very proud and wish you all the best for your new role as assistant professor @OliveiraMann 🧬
Carina de Oliveira Mann@OliveiraMann5 Sep 2023
Back to the roots! I am thrilled to announce that I have returned to my alma mater as Assistant Professor for Biomolecular Cryo Electron Microscopy at the School of Natural Sciences @TU_Muenchen. #WomenInSTEM #MomsInScience
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hopfnerlab retweeted
IMPRS-ML@IMPRS_ML25 Aug 2023
Want to join our community of #IMPRSsiveMinds 🧠? Then apply for a PhD position at the IMPRS-ML via our application portal from Friday 01.09. 🗓️ #phdposition #jobalert #imprsml #maxplanck #gradschool #science #research @MPI_Biochem @MPIforBI @TU_Muenchen @LMU_Muenchen
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Celebrating the accomplishment of Erik van de Logt! 🥳He successfully defended his PhD thesis on mechanistic insights into several DNA repair factors 🧬. Congratulations!
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Another great collaboration! Check out this publication about the activity of nucleosome remodeler Fun30. Thanks to everyone involved @pfanderlab @DuderstadtLab Till Bartke and Christoph Kurat labs Jerome Basquin @crc_1064 @MPI_Biochem life-science-alliance.org/co…

A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler

Fun30 is the prototype of the Fun30-SMARCAD1-ETL subfamily of nucleosome remodelers involved in DNA repair and gene silencing. These proteins appear to act as single-subunit nucleosome remodelers,...

life-science-alliance.org
PfanderLab@PfanderLab25 Jul 2023
We are very excited to share our work life-science-alliance.org/co… in @LSAJournal.

A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler

Fun30 is the prototype of the Fun30-SMARCAD1-ETL subfamily of nucleosome remodelers involved in DNA repair and gene silencing. These proteins appear to act as single-subunit nucleosome remodelers,...

life-science-alliance.org
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