@jpjhall

biology / microbiology / evolution https://xitter.cf/t.co/csJWhE4W55

 Liverpool, England
jpjhall.net
Joined May 2010
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🔔New preprint! In which we explore the ecological consequences of plasmid-bacterial compensatory evolution using models and experiments. With @rctwright, @2jamiewood, @ellieevolves, @DrKatieMuddiman, @MBottery, @scottishwormboy and @brockhurstlab 🧫💫🦠 biorxiv.org/content/10.1101/…

Superiority of chromosomal compared to plasmid-encoded compensatory mutations

Plasmids are important vectors of horizontal gene transfer in microbial communities but can impose a burden on the bacteria that carry them. Such plasmid fitness costs are thought to arise principa...

biorxiv.org
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Delighted to have this review out with @jpjhall! We discuss the risk of transmission of antimicrobial resistance in the hospital sink drain microbiome, highlight studies providing evidence of transfer, and consider strategies to mitigate these risks 🪠🦠 doi.org/10.1038/s44259-025-0…
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🏫You would be working mainly with me at @IVES_livuni — our lab sits between evolutionary ecology and infection microbiology. There’s loads of exciting research going on in both of these themes, and chances for discussions with other groups eg @jojofoth @jay_salsa
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🌊 Liverpool’s a great city and there’s loads to do — amazing parks, theatres and galleries, classic pubs, spectacular beaches, and your paycheck goes further than it might in other places.
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🗣️ Spread the word and get in touch if you are interested or if you have any questions!
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We even found conditions where plasmid-encoded CMs failed to outcompete uncompensated plasmids!
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We therefore expect plasmids have limited scope to 'play nice', and instead chromosomes have to evolve to accommodate unruly plasmids. Compensated strains could act as 'hubs' for plasmid accumulation, evolution, and dissemination, with implications for spread of AMR.
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Under a week left to apply!
Jamie Hall@jpjhall7 Nov 2023
🚨#PhD opportunity at @LivUni_IVES @ACCE_DTP🚨Do plasmids help soil microbes adapt to climate change? Join me and @RajWhitlock to investigate, using a 31-year-old climate experiment @BCCIL_UK 🌾🥵🦠 findaphd.com/phds/project/do…
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New preprint - we show that spatial refuges can facilitate evolutionary rescue to salt stress only when nutrient levels are high, but refuges can also constrain adaptations due to trade-offs associated with motility - with @jpjhall + others doi.org/10.1101/2023.11.21.5…
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🚨#PhD opportunity at @LivUni_IVES @ACCE_DTP🚨Do plasmids help soil microbes adapt to climate change? Join me and @RajWhitlock to investigate, using a 31-year-old climate experiment @BCCIL_UK 🌾🥵🦠 findaphd.com/phds/project/do…
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Please share, and get in touch if you are interested in applying 💻😀
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This Halloween, don't forget to check out and share with your friends and family the thrilling adventures of Luna and Simon. In this edition, they harnessed the power of phages against the superbugs 🧬🧫🎃👻 @andthemicrobes @edward_ross @jpjhall @luhflima
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Jamie Hall retweeted
Kate Baker@ksbakes10 Oct 2023
It's recruitment time @GeneticsCam 🦠🧫👏🥳 !!! 3 year computational postdoc doing cool Shigella AMR genomics with me and other fun people. Read more here jobs.cam.ac.uk/job/43349/ Would appreciate RTs!
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