@nchembio

A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.

 New York, USA
nature.com/nchembio
Joined March 2009
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762Media
Our November issue is live! nature.com/nchembio/volumes/… The cover image depicts the common midwife toad. Comparative peptidomics is used to reveal disease dynamics and variation in host AMP defenses to understand how toad populations can survive disease outbreak.
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Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells nature.com/articles/s41589-0…

Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells

Nature Chemical Biology - The chemogenetic tool Grubraw activates mitochondria by generating pyruvate in the mitochondrial matrix. This triggers a genetic switch that slows down tumor cell...

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Diversification distal to the electrophile of covalent stereoprobes alters their protein interaction landscape, revealing GRPEL1-HSPA9 disruptors and nonorthosteric liganding events missed by cofolding models nature.com/articles/s41589-0…

Tryptoline stereoprobe elaboration identifies inhibitors of the GRPEL1–HSPA9 complex

Nature Chemical Biology - Diversification distal to the electrophile profoundly alters the protein interaction landscape of covalent stereoprobes, revealing GRPEL1–HSPA9 disruptors and...

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A new paper reveals how the bacterial defense enzyme S. aureus USI repeatedly scans and makes multiple DNA breaks, efficiently fragmenting invading genetic material nature.com/articles/s41589-0…

Single Staphylococcus aureus SauUSI restriction enzyme motors fragment methylated DNA

Nature Chemical Biology - Using single-molecule physics and biochemical assays, Shaw, Hughes-Games and Torres Montaguth et al. reveal how the bacterial defense enzyme SauUSI repeatedly scans and...

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A selective NVL inhibitor suppresses tumor growth by targeting ribosome biogenesis nature.com/articles/s41589-0…

A selective NVL inhibitor suppresses tumor growth by targeting ribosome biogenesis

Nature Chemical Biology - Guo, Tao and Cruz et al. identified a selective inhibitor named MM17 of nuclear valosin-containing protein-like (NVL), an AAA+ ATPase responsible for assembly of large...

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PUS7 pseudouridylation of noncoding RNA 7SK orchestrates human somatic cell reprogramming into iPS cells nature.com/articles/s41589-0…

PUS7 pseudouridylation of 7SK orchestrates human somatic cell reprogramming into iPS cells

Nature Chemical Biology - PUS7 promotes pluripotency through modification of the noncoding RNA, 7SK, enhancing its interaction with the BRG/BRM-associated factor complex. Replacing exogenous OCT4...

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Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity nature.com/articles/s41589-0…

Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity

Nature Chemical Biology - Systematic proteomic profiling uncovered mechanisms driving drug toxicity informing the design of safer and more effective protein degraders for the treatment of prostate...

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High-resolution NMR spectroscopy of proteins in intact mitochondria nature.com/articles/s41589-0…
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QC6352, originally developed as a KDM4 inhibitor, exerts its anticancer activity in glioblastoma models primarily through inhibition of DHODH, a key enzyme in de novo pyrimidine biosynthesis nature.com/articles/s41589-0…

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

Nature Chemical Biology - QC6352, originally developed as a KDM4 inhibitor, exerts its anticancer activity in glioblastoma models primarily through inhibition of dihydroorotate dehydrogenase, a key...

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Cell-cycle-driven noncanonical ubiquitination of METTL14 orchestrates RNA methylation nature.com/articles/s41589-0…
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Cryo-EM structures of RNA polymerase II (Pol II) with cisplatin-induced DNA interstrand crosslinks (ICLs) reveal how Pol II remodels cisplatin-ICLs, stalls transcription, and commits lesions to transcription-coupled repair nature.com/articles/s41589-0…
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A nontoxic proximity labeling method generating H2O2 in situ from D-amino acids enables protein and RNA proximity labeling and mapping RNA structural changes in vitro and in vivo nature.com/articles/s41589-0…

Multiomic proximity labeling in vivo by D-amino-acid-activated peroxidase reaction

Nature Chemical Biology - A nontoxic proximity labeling approach is developed using an engineered D-amino acid oxidase and APEX2 fusion to generate H2O2 in situ from D-amino acids. It is applied in...

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SRSF1 modulates the dark nucleolar cap pH to restore nucleolar integrity and function nature.com/articles/s41589-0…
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A new Review highlights the mechanisms of molecules that disrupt translation in an amino acid or mRNA sequence-dependent manner nature.com/articles/s41589-0…

Halting translation by the letter with sequence-selective small molecules

Nature Chemical Biology - Small-molecule modulators of protein synthesis are invaluable tools for dissecting the translation apparatus. This Review summarizes the mechanisms of molecules that...

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Our October issue is live! nature.com/nchembio/volumes/… Inspired by the phases of the moon, the cover artwork uses light and darkness to depict pharmacological control of chimeric antigen receptor (CAR) T cells
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Small-molecule inhibitors of S. aureus efflux pump NorA trap NorA in an outward-open state, preventing antibiotic efflux and restoring antibiotic susceptibility nature.com/articles/s41589-0…

Small-molecule inhibitors block NorA efflux by conformational trapping

Nature Chemical Biology - Multidrug efflux pumps expel antibiotics, contributing to antibiotic resistance. Now, high-throughput screening and structural characterization reveal an inhibitor of...

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Allenes and alkynes can be biosynthesized via oxidative C(sp2)-demethylation of a prenyl group by fungal cytochrome P450s, expanding the catalytic repertoire of P450 enzymes nature.com/articles/s41589-0…
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Discover groundbreaking research and innovation in chemical biology at the Tri-Institutional Chemical Biology Symposium
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AvaS is a pyridoxal-phosphate-dependent RNA-modifying enzyme, producing the tRNA modification ava2C from k2C in bacteria and plants and linking RNA chemistry to translational regulation of metabolic stress responses nature.com/articles/s41589-0…
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A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes nature.com/articles/s41589-0…

A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes

Nature Chemical Biology - Noncanonical redox cofactors (NRCs) are promising alternatives to nicotinamide adenine dinucleotide (phosphate) (NAD(P)+) for biomanufacturing because of expanded...

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