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Science Advances

@ScienceAdvances

Science Advances is an open-access multidisciplinary journal, publishing impactful research papers and reviews in any area of science.

 AAAS - Washington, DC
science.org/journal/sciadv
Joined February 2014
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New research reveals how structural remodeling can alter the spatio-temporal organization of neurotransmission. Learn more in this week’s issue of Science Advances: scim.ag/4e5NHyd
Presynaptic filopodia, protrusions sprouting from nerve cell endings, promote membrane flow to help brain cells release neurotransmitters more closely timed to incoming electrical signals. Synaptic plasticity allows neural circuits to compute and adapt, but just how the structural remodeling of neurons affects their overall communication remains unclear. Jain et al. investigate how these tiny extensions influence the transmission of signals between nerve cells. They found that these extensions create temporary contact with nearby cells and cause the cell membrane to move, resulting in more precisely timed neurotransmitter release. These results reveal how structural remodeling can alter the spatio-temporal organization of neurotransmission. Credit: Jon Moss (Roslin Institute 3D Electron Microscopy Facility, University of Edinburgh) and Daniela Ivanova (University of Edinburgh)

ALT Presynaptic filopodia, protrusions sprouting from nerve cell endings, promote membrane flow to help brain cells release neurotransmitters more closely timed to incoming electrical signals. Synaptic plasticity allows neural circuits to compute and adapt, but just how the structural remodeling of neurons affects their overall communication remains unclear. Jain et al. investigate how these tiny extensions influence the transmission of signals between nerve cells. They found that these extensions create temporary contact with nearby cells and cause the cell membrane to move, resulting in more precisely timed neurotransmitter release. These results reveal how structural remodeling can alter the spatio-temporal organization of neurotransmission. Credit: Jon Moss (Roslin Institute 3D Electron Microscopy Facility, University of Edinburgh) and Daniela Ivanova (University of Edinburgh)

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Furan fatty acids reduces fat accumulation and inflammation in mice, a new study finds. Chemical engineering led to 11U3-2M, which significantly improved glucose tolerance, lipid imbalance, and fatty liver disease. @pitt_medicine scim.ag/4iaAwgi
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A new study proposes the Bacillus Calmette-Guérin vaccine as a preventative measure against dementia. The vaccine reduces Alzheimer’s-associated phospho-tau proteins, reprograms myeloid immune cells and limits neuroinflammation. scim.ag/4hZ0wN1
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Antarctic sea ice expansion and changes in ocean circulation work together to sequester carbon and reduce the amount of CO2 in the atmosphere during glacial climates, according to a new study. @eapsMIT scim.ag/3UbfmXG
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Science Advances retweeted
Lucas Pontel (@LucPontel) profile picture
Lucas Pontel@LucPontelOct 26
Cells make toxic metabolites every minute they’re alive. How do they survive them? In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇 science.org/doi/10.1126/scia…
NRF2 coordinates cystine import and glutathione use to sustain ferroptosis resistance and formald...

NRF2 coordinates cystine import and glutathione use to sustain ferroptosis resistance and formald...

Cancer cells must balance detoxification of reactive metabolic by-products while preserving redox homeostasis, but how this trade-off is managed remains unclear. The Kelch-like ECH-associated protein...

science.org
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Researchers have developed a multiplexed and implantable fiber sensor that monitors the bloodstream for real-time levels of sodium and potassium, two electrolytes that regulate important bodily functions like heart rhythm and fluid balance. scim.ag/3W0Iu4r
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Researchers have found that forecasts starting from La Niña conditions were able to predict El Niño events up to a year in advance over 70% of the time. scim.ag/4BkreHw
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A new “digital twin” framework shows that two out of nine FDA-approved drugs have the potential to treat preterm labor. scim.ag/4jtldBT
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Reduced activity in the brain’s beta waves may be a neural marker for schizophrenia, according to research involving 25 patients. scim.ag/4zdOPrK
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A new device can detect scents and transmit them between people across distances, with the potential for long-range transmission. It marks another stage in the development of human-machine interfaces: enabling the sharing of smell. scim.ag/3W2F4hw
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Researchers have developed a single-cell–level digital twin to simulate how different treatments can alter maternal immune pathways and affect the time to labor of individual patients. Learn more this week in Science Advances: scim.ag/4k8o4Ap
Illustration of a digital twin modeling different potential outcomes to preterm birth treatments. Credit: Clara Leibenguth

ALT Illustration of a digital twin modeling different potential outcomes to preterm birth treatments. Credit: Clara Leibenguth

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Vitamin D binding protein derived from the neurons of the ventral hippocampus of mice participates in the pathogenesis of stress-induced depression, marking it as a potential therapeutic target for major depressive disorder. scim.ag/4im47oo
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Science Advances is publishing an Erratum for the October 2025 Research Article "The design and reconstructible history of the Mayan eclipse table of the Dresden Codex.” scim.ag/4hYawoi
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By modeling the impacts of the Kikai-Akahoya eruption on the Jomon foraging communities then occupying the Japanese archipelago, researchers found evidence of both population collapse and increase in different communities after the catastrophe. @er_crema scim.ag/47TqdbT
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Science Advances is publishing an Erratum for the August 2023 Research Article "FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer.” scim.ag/3TSL7Vm
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sebastiano curreli (@ZebaCurreli) profile picture
sebastiano curreli@ZebaCurreliOct 17
Want to get clean calcium signals from tons of deep-brain neurons in freely moving animals? ​Check our paper science.org/doi/10.1126/scia… ! We show how correcting GRIN lens aberrations transforms MINI2P performance, revealing sparse HD coding in sensory thalamus! @ScienceAdvances
Extended field-of-view two-photon imaging in the deep brain of freely behaving mice using lightwe...

Extended field-of-view two-photon imaging in the deep brain of freely behaving mice using lightwe...

Investigating neural circuits underlying complex behavior requires high-resolution imaging of large neuronal populations during naturalistic conditions. Miniaturized two-photon microscopes (MINI2Ps)...

science.org
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Coexposure to heatwaves and air pollution from landscape fires has been increasing globally over the past 2 decades, according to a new analysis. scim.ag/4dEcPf6
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Bacteria can escape viral predators by collectively swimming along chemical gradients, which allows the population to outpace the spreading infection, according to a new study. @TheSquishyLab @Caltech @Princeton scim.ag/4im5B1W
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Breast milk antibodies show broad antiviral activity and protect mice against influenza, according to new research. scim.ag/4ymmEWq
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Muscle stem cells build a shield out of the glycoprotein Fibrillin-1 to stay dormant and protected from unusual growth factor signaling, depletion of the stem cell pool, and progressive decline in muscle function. scim.ag/4zyp0lZ
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