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eLife - the journal

@eLife

The funder-researcher collaboration and open-access journal for research in the life and biomedical sciences | @eLifeCommunity

 Cambridge, UK
elifesciences.org
Joined September 2011
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Negative affect influences the computations underlying food choice in bulimia nervosa elifesciences.org/articles/1…
Negative affect influences the computations underlying food choice in bulimia nervosa

Negative affect influences the computations underlying food choice in bulimia nervosa

In bulimia nervosa, negative affect exaggerates a taste-before-health bias in food decision-making, and this bias is associated with more frequent out-of-control eating.

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Genome-wide discovery of cis-regulatory elements in a large genome elifesciences.org/articles/1…
Genome-wide discovery of cis-regulatory elements in a large genome

Genome-wide discovery of cis-regulatory elements in a large genome

Integrating genome-wide maps of chromatin accessibility and sequence conservation provides an accessible low-cost approach for identifying cis-regulatory elements in large genomes, validated in the...

elifesciences.org
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Zinc is a key regulator of the sperm-specific K+ channel (Slo3) function elifesciences.org/articles/1…
Zinc is a key regulator of the sperm-specific K+ channel (Slo3) function

Zinc is a key regulator of the sperm-specific K+ channel (Slo3) function

Intracellular zinc dynamically changes during sperm capacitation and regulates Slo3-mediated hyperpolarization, while directly inhibiting Slo3 currents through residues contributing to its slow...

elifesciences.org
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Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms elifesciences.org/articles/1…
Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms

Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms

Bridging biophysical neuron models with tractable population dynamics opens a route to whole-brain investigation of ion-driven pathological states such as epilepsy and their potential therapeutic...

elifesciences.org
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Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation elifesciences.org/articles/1…
Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

Phospholipase Cβ3 is translocated and activated by the heterotrimeric G protein subunit Gαq at the plasma membrane, but the Gβγ heterodimer is required for maximum activation.

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Learning is a fundamental source of individuality elifesciences.org/articles/1…
Learning is a fundamental source of individuality

Learning is a fundamental source of individuality

Beyond genotype × environment interactions, which can be shared and identical across individuals, learning from uniquely individual experiences further defines and diversifies individual behaviour.

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Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles elifesciences.org/collection…

Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

eLife publishes research on the mechanisms and biological significance of environmentally driven epigenetic inheritance.

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PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons elifesciences.org/articles/1…
PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal...

PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal...

Apical PKD2L1 channels generate phasic and sustained currents that together make spinal cerebrospinal fluid-contacting neurons exquisite pH sensors.

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Dissociable roles of reward prediction error in the contrasting mood dynamics of depression and anxiety elifesciences.org/articles/1…
Dissociable roles of reward prediction error in the contrasting mood dynamics of depression and...

Dissociable roles of reward prediction error in the contrasting mood dynamics of depression and...

Depression-specific symptoms blunt mood responses to unexpected outcomes, whereas anxiety-specific symptoms amplify them in non-clinical participants, with depression-related blunting also replicated...

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Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent gene expression in gastruloids elifesciences.org/articles/1…
Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent...

Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent...

Detailed, single-cell spatial gene expression across multiple gastruloids highlights macro-scale organizational consistency, simultaneous with variance in meso-scale patterning.

elifesciences.org
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A real-time, multi-animal model for automatic face detection and identification of freely moving common marmosets based on YOLOv8 algorithms elifesciences.org/articles/1…
A real-time, multi-animal model for automatic face detection and identification of freely moving...

A real-time, multi-animal model for automatic face detection and identification of freely moving...

A generalizable computational approach automatically identifies individual common marmosets to serve as support for presenting and analyzing behavioral tasks without relying on extensive manual work.

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Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons elifesciences.org/articles/1…
Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle...

Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle...

Single-molecule motility assays and live-cell imaging in neurons reveal that tau hyperphosphorylation disrupts the formation of cooperative tau envelopes along microtubules and lysosomal transport.

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Selective lifelong suppression of an odor processing channel in response to critical period experience elifesciences.org/articles/1…
Selective lifelong suppression of an odor processing channel in response to critical period...

Selective lifelong suppression of an odor processing channel in response to critical period...

Utilizing the olfactory system of Drosophila, a critical period paradigm has provided new insight into the selectivity and longevity of the impact of early life experiences on sensory system circui...

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Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase elifesciences.org/articles/1…
Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase

Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase

Trimethylamine N-oxide demethylase uses substrate channeling to couple trimethylamine N-oxide demethylation with one-carbon metabolism, safely detoxifying formaldehyde while enhancing metabolic...

elifesciences.org
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Opening the black box toward a modular approach to spike sorting elifesciences.org/articles/1…
Opening the black box toward a modular approach to spike sorting

Opening the black box toward a modular approach to spike sorting

Modularized spike sorting pipelines can identify performance bottlenecks, lower contribution barriers, and enable the development of highly accurate algorithms to turn extracellular recordings into...

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Two Glu/Asp residues cooperatively mediate an early step of ATP hydrolysis in GHKL ATPases MutL and GyrB elifesciences.org/articles/1…
Two Glu/Asp residues cooperatively mediate an early step of ATP hydrolysis in GHKL ATPases MutL and...

Two Glu/Asp residues cooperatively mediate an early step of ATP hydrolysis in GHKL ATPases MutL and...

A cooperative catalytic mechanism provides a revised framework for understanding ATP hydrolysis in a broad subset of GHKL ATPases.

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Retinal curl as a functional signal for heading estimation beyond the focus of expansion elifesciences.org/articles/1…
Retinal curl as a functional signal for heading estimation beyond the focus of expansion

Retinal curl as a functional signal for heading estimation beyond the focus of expansion

The rotational retinal flow generated by natural gaze stabilization is not merely visual noise to be subtracted but actively shapes human heading perception.

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Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila elifesciences.org/articles/1…
Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila

Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila

Wild-type flies anticipate daily respiratory demands by coordinating substrate use, whereas short-sleep and clock-deficient mutants shift toward reactive fuel use and altered redox metabolism.

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Developmental synchrony of retinal waves, apoptosis, and angiogenesis in postnatal retina elifesciences.org/articles/1…
Developmental synchrony of retinal waves, apoptosis, and angiogenesis in postnatal retina

Developmental synchrony of retinal waves, apoptosis, and angiogenesis in postnatal retina

An interdisciplinary approach uncovers a never-before-seen multifaceted synchrony of developmental processes in the rodent retina which are driven by purinergic signalling from apoptotic retinal...

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