A Streamlined AAV Purification Process via Engineered Affinity Tag-Assisted Liquid-Liquid Phase Separation dlvr.it/TWJKfF #MTMCD
Validation of an agonistic canine anti-CD3ε antibody for the production of metabolically fit T cells for adoptive therapy dlvr.it/TWJKWl #MTMCD
Cryo-EM Mapping of Human Neutralizing Antibodies Reveals 3-fold Antigenic “Hotspot” on the AAV2 Capsid dlvr.it/TWJKPB #MTMCD
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A single-nucleotide change in the Kozak sequence enhances protein expression from IVT mRNA dlvr.it/TWJKN8 #MTNA
LILRB1 as a novel therapeutic target for CAR-T therapy in diffuse large B cell lymphoma dlvr.it/TWJ8mz #genetherapy #celltherapy
A modular AU-rich stem-loop in the 3′ UTR enhances protein expression through L1RE1 dlvr.it/TWJ4y5 #MTNA
From self-amplification to engineered replication: Designing next-generation saRNA platforms dlvr.it/TWHz03 #MTNA
Assessing Germline Transmission Risk and First-in-Human Dose Selection for In Vivo Gene Therapies dlvr.it/TWHBx7 #MTMCD
An integrated enzymatic and computational pipeline for quantifying off-target base-editing dlvr.it/TWHBsW #MTMCD
Cas9 Immunogenicity and Translational Implications for CRISPR-Cas9 Mediated Gene Therapy Interventions dlvr.it/TWGlVj #MTNA
A single-dose combinatorial gene therapy with AAV based FGF21 and SIRT1 impacts aging-associated metabolic and mitochondrial function dlvr.it/TWGlMr #MTNA
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A combination TLR7/8 and RIG-I agonist adjuvant reverts asthmatic allergic sensitization and prevents aggravated influenza infection in mice dlvr.it/TWGVsr #MTMCD
A dual-function adenoviral system for transgene delivery and gene editing for host factor studies in a murine model of SARS-CoV-2 infection dlvr.it/TWGVmF #MTMCD
Programmable Transcriptional Activation in Human iPSC-Derived Hepatocyte Metabolic Stress Culture for Target Discovery dlvr.it/TWGNr7 #MTMCD
We're excited to share that Paloma Giangrande, PhD, has been appointed to a second term as Editor-in-Chief of Molecular Therapy Nucleic Acids (@MTJournalNews), beginning in January 2027. Congratulations on this well-deserved appointment!
Read more: bit.ly/4iJGXHD
AAV6-Gsx1 promotes sustained functional recovery in a pilot long-term study after contusion spinal cord injury dlvr.it/TWFz63 #MTMCD
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Molecular engineering of zinc finger nucleases significantly enhances genome editing efficiency in cells dlvr.it/TWFz1v #MTNA
In this issue dlvr.it/TWFywk #genetherapy #celltherapy
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Therapeutic Landscape of Folate Receptor-α Targeting: Platforms, Progress, and Clinical Translation dlvr.it/TWFkyZ #genetherapy #celltherapy
Combination in vivo HSPC gene therapy for HIV by CCR5 knockout and decoy receptor dlvr.it/TWF1hb #MTMCD
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