The Science of #Parkinsons will be out of office for the next few day Behave yourselves

‘To Hear and Be Heard’ The co-design of a website to support communication challenges experienced by people With #Parkinsons & their families & friends onlinelibrary.wiley.com/doi/…

There is a special issue of the @journal_PD providing the proceedings of the 7th World #Parkinsons Congress @WorldPDCongress journals.sagepub.com/toc/pkn…

Single-nucleus phosphatome rewiring & phosphoproteomics reveal PFKFB2 as an LRRK2-linked metabolic node in the human Substantia Nigra of #Parkinsons patients pubs.acs.org/acsodf/article/…

Interesting new @biorxivpreprint: Frontal stimulation reshapes SCAN connectivity & improves motor function in #Parkinsons biorxiv.org/content/10.64898…

Everything you ever wanted to know about human DOPA Decarboxylase - from monoamine metabolism, pharmacology, & synucleinopathies; "AADC measured in cerebrospinal fluid has emerged as one of the most discriminating fluid biomarkers for #Parkinsons & LBD" pubs.acs.org/abmcb8/article/…

Researchers present evidence for the involvement of laterodorsal tegmental nucleus-ventral part (the putative human homologue of the murine sublaterodorsal nucleus) in isolated REM sleep behaviour disorder (Structural MRIs; n=98 iRBD & 114 controls) academic.oup.com/braincomms/…

New review examines the role of mitochondrial biomarkers in improving diagnostic accuracy, patient stratification & monitoring of disease progression & therapeutic response across neurology (including a useful section on #Parkinsons) nature.com/articles/s41582-0…

New data finds that in patients with #Parkinsons & neurogenic orthostatic hypotension (OH), ambulatory hypertensive episodes were associated with better clinical outcomes, an association not observed in patients with non-neurogenic OH onlinelibrary.wiley.com/doi/…

Researchers use PPMI data to identify a 7-protein cerebrospinal fluid (CSF) proteomic signature (CCL27, CXCL9, NEFL, SERPINE1, GH1, TYMP, KLK1) that exhibited good discriminative performance for distinguishing rapid from slow #Parkinsons progressors movementdisorders.onlinelibr…

Researchers present "DPEU" - a small-molecule modulator of VDAC function that promotes ATP flux in β cells through a mechanism distinct from the classical KATP or cAMP pathways, identifying VDAC as a potential target for enhancing insulin secretion cell.com/cell-chemical-biolo…

Researchers report the first potent & selective covalent inhibitor of USP32 together with the first cell-permeable activity-based probes for this deubiquitinase cell.com/cell-chemical-biolo…

A study of chronic rotenone administration (21 days) in mice finds #Parkinsons-like behaviour after 4 weeks, but "after 12 months of toxin cessation, rotenone-treated mice exhibited behavioral performance & TH expression levels" comparable to controls cell.com/iscience/fulltext/S…

An international group of leading microbiome scientists, convened by the @HHSGov, presents a strategic vision for realizing its potential to transform public health. They outline 10 strategic priorities for research and public health nature.com/articles/s41591-0…

New research identifies USP18 as a potential regulator of ferroptosis in #Parkinsons & "reveal the central role of the USP18–SLC7A11 axis in dopaminergic neuronal loss, suggesting that USP18 holds promise as a potential therapeutic target for PD" nature.com/articles/s41419-0…

Researchers identify candidate markers for the isolation of neuron-specific extracellular vesicles, with Neurexin 3 (NRXN3) being highlighted - even in a small pilot study of #Parkinsons samples (no difference with controls) nature.com/articles/s41593-0…

More weekend reading: New review explores cytokine circuits in CNS homeostasis; "CNS cytokine circuits may also be shaped by systemic immune & metabolic cues, whose influence on local cytokine production & responsiveness remains incompletely understood" nature.com/articles/s41590-0…

Weekend reading: New review examines gut dysbiosis, tryptophan metabolism, & aryl hydrocarbon receptor signaling as potential mechanisms underlying idiopathic #Parkinsons & highlights their relevance to early diagnosis and disease-modifying therapies nature.com/articles/s42003-0…

New nationwide (South Korea) cohort study suggests a potential association between higher cumulative proton pump inhibitor exposure (≥ 180 days of use) & an increased risk of #Parkinsons nature.com/articles/s41598-0…

Researchers propose a new model based on complementary MRI modalities to provide an objective clinical decision-support measure for #Parkinsons with potential applications in other parkinsonisms (multiple system atrophy, progressive supranuclear palsy) academic.oup.com/braincomms/…