Founded in 1908, the ASCI is home to 3,500+ physician-scientists across academic medicine and industry.
Ann Arbor, MI
Joined June 2017
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ASCI member Goutham Narla @gouthamnarla & colleagues just published a new paper @JCI_insight (doi.org/10.1172/jci.insight.…)!
In this glimpse Behind the Paper, (1/4) Dr. Narla & Dr. O'Connor discuss results; (2/4) Dr. Romero-Murillo & Dr. Peris count CD34+ colonies; (3/4) Dr. Romero-Murillo shares the results during her PhD defense; and (4/4) Dr. Romero-Murillo, Nerea Marcotegui, Dr. Odero, Dr. Vicente, and Dr. Peris (left-to-right) say hello from Dr. Odero's laboratory. 🧵
Stabilization of the PP2A-B56α complex overcomes venetoclax-azacitidine resistance by impairing OXPHOS in AML: doi.org/10.1172/jci.insight.… 🧵
ASCI retweeted
Congratulations to Gladstone Investigator Christina Theodoris who has been named the recipient of the prestigious 2026 Seldin-Smith Award for Pioneering Research! @the_asci
bit.ly/4e263jw
Congratulations Dr. Christina Theodoris @TheodorisLab, recipient of the 2026 Donald Seldin~Holly Smith Award for Pioneering Research!
Dr. Theodoris @GladstoneInst is recognized for her work in computational biology, leveraging AI to understand cell regulation and cell-cell interactions and to produce models that reason about disease states.
ASCI retweeted
Three days left to submit your abstract! 🤩
The AAP/ @the_asci / @A_P_S_A 2027 Joint Meeting will take place from April 9-11 in Chicago, Illinois. Submit and apply for travel awards by Monday, October 26: ow.ly/wSxi50ZVrJV
ALT A flyer for the AAP/ASCI/APSA 2027 Joint Meeting in Chicago, April 9-11, with a call for abstract submissions by the October 26 deadline and a QR code for application.
Don’t miss your chance to present your poster at the 2027 AAP/ASCI/APSA Joint Meeting. Submit your abstract by Monday, October 26th 11:59 PM ET.
All career stages welcome!
Featured video: Zachary M. Chan presenting his research project from Neil J. Kelly’s lab at the 2026 AAP/ASCI/APSA Joint Meeting poster session.
More info: buff.ly/Iq6VZFY
ASCI retweeted
Malignant peripheral nerve sheath tumors are rare, aggressive soft tissue sarcomas lacking meaningful treatment options. Here (doi.org/10.1172/JCI201331), Angela C. Hirbe @AngelaHirbe & team @washumedicine show dual inhibition with FAK and RAF/MEK overcomes resistance, suppresses growth, and induces tumor regression in preclinical studies of chromosome 8 gain malignant peripheral nerve sheath tumors.
@sargoshoe @the_asci
#MPNST #Sarcoma
ASCI retweeted
As part of JCI’s review series on emerging therapeutic strategies in breast cancer, Carlos L. Arteaga & colleagues present: PI3K signaling in #BreastCancer: therapeutic advances versus adaptive resistance: doi.org/10.1172/JCI207635
Mutations in the PI3K pathway are common oncogenic drivers of breast cancer, but therapeutically targeting the pathway has proved challenging. In this review, Fabiana Napolitano @md_napolitano, Carlos L. Arteaga @CarlosArteagaMD et al. @UTSWMedCenter provide an up-to-date synthesis of PI3K inhibitor development and offer insights into how our understanding of resistance mechanisms will guide future efforts for rational therapeutic sequencing.
@the_asci
Katherine A. High, MD, is presenting our first Scientific Session of the 2026-2027 Academic year!
Friday, October 23, 1-2pm Eastern.
Moderated by David Ginsburg, MD
Details and Registration: buff.ly/TaxfECb
📣 Deadline extension: The abstract submission deadline for 2027 AAP/ASCI/APSA Joint Meeting has been extended to October 26th!
👉 buff.ly/Iq6VZFY
📣 Call for posters: The ASCI is now accepting abstract submissions for the 2027 AAP/ASCI/APSA Joint Meeting
Deadline: October 12, 2026
More info: buff.ly/Iq6VZFY
ASCI retweeted
The @SocPedResearch and @AmerPedSociety were thrilled to be signers on this important letter about proposed changes to NIH K awards. Thanks to @the_asci for their leadership on this.
Today @the_asci published an open letter to NIH leadership on proposed changes to K awards, co-signed by 30 professional societies and foundations. Thank you to the ASCI working group and every society and foundation that signed. beta.the-asci.org/news/advoc…
📣 Call for posters: The ASCI is now accepting abstract submissions for the 2027 AAP/ASCI/APSA Joint Meeting
Deadline: October 12, 2026
More info: buff.ly/Iq6VZFY
ASCI retweeted
A new urine test may help doctors diagnose #cystinosis earlier, potentially improving care for children with this rare #KidneyDisease. doi.org/10.1172/jci.insight.….
Jason H. Greenberg @JasonHenryG @YaleMed, Chirag R. Parikh @KidneydrChirag @HopkinsMedicine & team compared YKL-40 to other known makers of disease, showing a marked increase in urine and biopsies from patients with cystinosis. This proof-of-concept study supports the use of urine YKL-40 as highly potent biomarker of disease.
ASCI member Chirag R. Parikh @KidneydrChirag and colleagues have a new paper in JCI Insight! In this peek Behind the Paper, authors Serena D. Souza and Wassim Obeid work on the new urine test that may help with earlier diagnosis of the rare kidney disease cystinosis in children.
📎 Urine YKL-40 as a diagnostic biomarker of cystinosis | Greenberg (@JasonHenryG) et al.: doi.org/10.1172/jci.insight.…
📣 Nominations are OPEN
for the 2027-2029 ASCI Postbaccalaureate Program!!
🔹 2 Postbacs Awarded
🔹 2 year laboratory research experience
🔹 ASCI-member lab
🔹 Immersive and mentored
🔹 MCAT and Med School Application Prep
Learn more: buff.ly/uF7BsNQ
ASCI retweeted
🧵 1/2: We previously posted about Kim et al. as a landmark in cardiac metabolism.
✏️ In a recent Letter to the Editor, Rong Tian @TianLab @UW & E. Douglas Lewandowski @OhioState discuss the challenges of interpreting double deletion data in the absence of similar analysis for each gene deletion: doi.org/10.1172/JCI209270
Making sense of cardiomyopathy caused by deletion of acetyl-CoA carboxylase 1 and 2
#LetterToTheEditor
@the_asci
A landmark in cardiac metabolism: doi.org/10.1172/JCI202528
Jay D. Horton & team @UTSWMedCenter find unrestrained fat oxidation in heart cells deplete cardiolipins that are needed for mitochondrial energy, triggering heart failure in mice and revealing a potential metabolic target.
The figure shows decreased heart function in cardiac-specific ACC1/ACC2 double KO (dHKO) mice.
#CardiacMetabolism #HeartFailure
ASCI retweeted
Suggesting a novel therapy for #SystemicSclerosis: doi.org/10.1172/jci.insight.…
Eduardo Marbán & team @Marbanlab @CedarsSinai report that an orally delivered noncoding RNA (TY1) reduces inflammation and organ fibrosis in models of systemic sclerosis through inhibition of the cGAS/STING axis. The authors employed in vitro and in vivo models and evaluated skin, lung, and heart.
The video shows TY1 treatment in preclinical models of systemic sclerosis.
@AleCiulloPhD @TheIbrahimlab @the_asci
📣 Nominations are OPEN
for the 2027-2028 ASCI PSSF Fellowship Program!!
🔸 5 Fellowships Awarded
🔸 MD-or DO-only medical students
🔸 Med school research gap year (12 months)
🔸 Physician-scientist track
🔸 Immersive and mentored
Learn More: buff.ly/0bsi5B8
ASCI retweeted
Dietary fats drive aberrant tissue repair in #obesity: doi.org/10.1172/JCI205829
Obesity is linked to impaired healing, including #HeterotopicOssification (HO), or bone formation, at the injury site. Benjamin Levi & team @UTSW_Surgery implicate dietary #Omega6 lipids in this elevated risk for HO.
Image: High-fat diet increased COX-2 expression (green) at the HO site in a mouse model. COX-2 dependent prostaglandin E2 production promoted osteochondral differentiation in mesenchymal progenitor cells.
@aaronwjames_lab @BTBKGMD @the_asci
ASCI retweeted
Proposing a combination treatment for reducing death from cerebral malaria: doi.org/10.1172/JCI202285
Alvin H. Schmaier @AlvinSchmaier & team @cwru report on a role for bradykinin in cerebral malaria and find plasma kallkrein inhibitors target host-mediated vascular dysfunction. Combination treatment using kallikrein inhibition and artesunate showed therapeutic benefit in mouse models.
@the_asci
#CerebralMalaria
