Org Chemistry lab focused on asymmetric catalysis and medicinal chemistry at @IRBBarcelona. Professors Antoni Riera and Xavier Verdaguer. Student run account.
Barcelona
Joined June 2016
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Have you ever heard of phosphinitos?
In our latest work, we show that P*-stereogenic phosphinitos can serve as powerful ligands in asymmetric catalysis. We look forward to seeing what else these ligands can achieve!
Congrats to @martichickpea and team!
advanced.onlinelibrary.wiley…
Another fascinating year of demonstrations by our group at the IRB Barcelona Open Day. Great to reach out to the community and show off the excitment of chemistry! Many thanks to @IRBBarcelona for organising this fantastic event.
URSAchem retweeted
La setmana passada vaig presentar la feina feta a @URSAchemlab a la @rqo_scq2025. Va ser un plaer poder participar-hi i veure la química fascinant que fem al país!
Congrats to our PhD graduate Dr. Marina Bellido (@marinabellidom) and PhD student Marti Sidro (@martichickpea) for their recent work in developing the p-stereogenic phosphane ligand, MAdPHOS, which provides outstanding enantioselectivities in asymmetric hydrogenation of enamides!
Check out our latest work in @JOC_OL where we prepare a novel P-stereogenic phosphane ligand named MAdPHOS at @URSAchemlab together with @helsoleav and @martichickpea
pubs.acs.org/doi/abs/10.1021…
Check out our work preparing 3,3-diarylallyl phthalimides as single diastereomers. we use this approach to synthesise various cyclopropylamines and achieve their highest enantioselectivities reported to date!
pubs.acs.org/doi/full/10.102…
Congrats to Martí Sidro (@Maarti164 ) et al!
Our PhD student Sergi Rafael presented his work at @IRBBarcelona as part of the Research Nodes Seminar series. He explained his exciting research in Proximity-induced Pharmacology and its application toward developing novel treatments for evasive cancers. Well done Sergi!
☑ 3 Component Synthesis
☑ 2 Step Tandem Reaction
☑ 1 Pot
We are delighted to report our novel synthetic approach for synthesising (2-Arylallyl) Aryl Sulfones! 🧪
@AdvSynthCatal
Check it out:
onlinelibrary.wiley.com/doi/…
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We report a greener preparation of these chemical intermediates and demonstrate their versatility by incorporating this methodology into the formal synthesis of the pharmaceutical Apremilast.
Congratulations to Dr. Marina Bellido (@marinabellidom) and all authors involved!
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URSAchem retweeted
#PCBCommunity | @CrisMayorRuiz, group leader del laboratorio de Degradación Dirigida de Proteínas y Descubrimiento de Fármacos del @IRBBarcelona, gana el Premio 60 Aniversario Farmaindustria Jóvenes Investigadores. ¡Felicidades! 👏🔝
@Farmaindustria #cancer
Cristina Mayor-Ruiz, del @IRBBarcelona, ganadora del Premio 60 Aniversario Farmaindustria Jóvenes Investigadores 👏
Ha trabajado en el descubrimiento de nuevos fármacos para frenar el cáncer, con una modalidad terapéutica nueva y aplicada, entre otros, a pacientes pediátricos
Our recent paper in collaboration with Dr. Cristina Mayor-Ruiz has made the cover of Angewandte! Congratulations to our PhD student/graphic design wizard, #Sergi Rafael and all the authors involved in its design!
#OnTheCover NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders (Mayor-Ruiz and co-workers) onlinelibrary.wiley.com/doi/… @CrisMayorRuiz @IRBBarcelona @BarbMGBarbosa @KarenSfyaki onlinelibrary.wiley.com/doi/…
URSAchem retweeted
#IRBBarcelona scientist @CrisMayorRuiz to participate in the @CancerGrand team #PROTECT, to apply targeted protein degradation against various types of paediatric tumours.
@ContraCancerEs is involved in this global funding initiative and supports this project, which will last for 5 years.
➡️bit.ly/4acV0jg
URSAchem retweeted
En esta convocatoria de @CancerGrand Challenges, en @ContraCancerEs apoyamos a la Dra. @CrisMayorRuiz (@IRBBarcelona) y su participación en el proyecto PROTECT para el desarrollo de tratamientos efectivos para cánceres infantiles. #investigandoencáncer
➡️contraelcancer.es/es/investi…
URSAchem retweeted
🆕Chemical rewiring of ubiquitination by #degraders and their selectivity routes.
✍️Rory Whelan & @CrisMayorRuiz
📰🎂@NatureSMB’s 3⃣0⃣th anniversary issue!
🔗shorturl.at/gmBIK
📌doi.org/10.1038/s41594-024-0…
#IRBScience #TPD
URSAchem retweeted
💊New drug reveals a key mechanism to overcome resistance to #ProteinDegraders.
✍️ @BarbMGBarbosa @KarenSfyaki @ferran_jose99 Sergi Rafael @CrisMayorRuiz @URSAchemlab et al.
📰 @angew_chem
➡️shorturl.at/gnFJY
📌doi.org/10.1002/anie.2023167…
#IRBScience #TPD
A great day at the @_BIST Forum 2024!
Congratulations to Dr. Antoni Riera and Dr. @SaraSdelci who presented their project EXPLODE-TNBC. This work aims to apply targeted protein degradation to find treatments for the elusive breast cancer type, Triple-Negative Breast cancer.
Dr. @SaraSdelci (@CRGenomica-#IRBalumni) & Dr. Antoni Riera (#IRBBarcelona-@URSAchemlab) present their joint project EXPLODE-TNBC: Seeking a Targeted Therapy for Triple-Negative Breast Cancer, which was awarded the second phase of @_BIST Ignite Award.
URSAchem retweeted
📢We are hiring! #PhDposition at @VHIO
🎯We aim to uncover novel patterns of chromosome instability in #cancer using
💻multi-omic analyses
🧬functional validations
💊to impact in patients
My group▶️vhio.net/pf/sarcoma-translat…
Apply▶️vhio.net/es/vhio-phd-opportu…
Questions? DM or email!
A busy week for publications in @URSAchemlab! Check out our accepted article in @AdvSynthCatal. We report an aluminum-catalyzed regioselective isomerization of 2,2-disubstituted oxetanes to yield homoallylic alcohols.
onlinelibrary.wiley.com/doi/…
👇(1/2)
We apply this wide-scope reaction toward the synthesis of curcuquinone and the σ1 receptor agonist RC-33. Special congratulations to Dr. Marina Bellido and Carlos Riego! (@carlosriego_99)
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