molecular programming @subseqbio

Joined September 2021
Today I'm announcing a protein compute web service: subseq.bio It's a simple web tool to submit compute-intensive tasks related to protein design, and biotechnology jobs. You can select from state-of-the-art, open source protein ML models, pre-configured and can begin running within minutes. Currently supported are RFdiffusion, and Alphafold (v2), with more coming. There are no restrictions on your output data. Just select the program, enter program arguments, and an optional upload folder, and click submit. Download the output data when finished. It is pay-per-use: Jobs are charged from your account credits when submitted. You can top up credits easily, any time. Currently jobs cost between 5¢ - $1. Feedback is important! Let me know ways it can be improved. More features are coming. For detailed updates please follow @subseqbio
10
11
74
9,765
Here's a chance to try serious biomolecular design work. This is enough credits for multiple full design campains, or hundreds of biomolecular design jobs!
🎉PROMO: To celebrate major program releases, RFD4-Proteina and BioEmu2, as well as other major improvements, you may use a new promo code (check image) for $100 worth of credits. To apply, go to account -> Funding -> Use Promo
2
9
860
another step towards protein nanotechnology
RFD4-Proteina is now available on Web, API, and MCP! A joint release by Baker Lab and NVIDIA: design biomolecular complexes with sequence–structure co-design, motif and binding-site conditioning, and partial diffusion. Try it now for free on Subseq!
2
13
672
BioEmu2 available on @subseqbio! I'll be playing around with some big complexes
BioEmu2 is now available on web, API, and MCP! Equilibrium ensemble sampling for proteins, nucleic acids & ligands — up to ~1,000,000× faster than traditional md simulation github.com/microsoft/bioemu2
1
1
16
920
Emin Bursa retweeted
Got a molecular design idea? Send it over and have all work done for you, from concept to ranked candidates. Use the new form, or DM here or @0xCF88
1
2
308
Emin Bursa retweeted
Have you used local AI? (open weight LLMs on your own hardware) If so how much
22%nope
57%tried it
22%use it often
0%more than claude/gpt/etc
23 votes • Final results
2
2
2
367
Have you used local AI? (open weight LLMs on your own hardware) If so how much
22%nope
57%tried it
22%use it often
0%more than claude/gpt/etc
23 votes • Final results
2
2
2
367
Emin Bursa retweeted
2.fecace4d
2
3
2
68
Emin Bursa retweeted
Replying to @ATinyGreenCell
I'm building a biomolecular design platform @subseqbio It's awesome because it provides latest bio tools exposed to both humans and agents. The interface is geared for de novo protein design and easy monitoring of bio agents. (It's also fast and fairly cheap)
2
17
590
Untied symmetric mpnn sequence redesign actually beats tied. (differing chain sequences)
1
20
1,295
OpenAI has decided to fully shut down a protein design project I'm working on for a client. Needless to say, open weight models are the only way forward.
68
231
19
3,712
116,564
Interestingly, bioemu takes msa's and clearly improves results. The AI agent decided to experiment with bioemu settings: msa and physical steering for villin (1VII), via glm-5.2
1
9
66
4,409
colony PCR gel analysis by glm-5.3 flash on 4x gb10 cluster
1
1
13
1,099
Emin Bursa retweeted
🧬 Protenix-v2 is now available on subseq A high-accuracy all-atom cofolder for challenging antibody–antigen complexes, #3 on CoFold Arena, with optional physics-guided protein–ligand sampling. github.com/bytedance/Proteni… Available over web, API & MCP
3
9
54
3,296
The accuracy is going to heavily depend on what AI model you choose to use, even smaller open weight models can be quite accurate, but the main weakness is total quantity estimation, so you'll get much better results if you give any sort of quantity reference per log. 4/n
1
39
You can share day summaries as exported images, here's mine from yesterday (feel free to judge me)
29