i am a huge proponent to the importance of keeping a steady circadian rhythm but one night of no sleep is literally the fastest antidepressant that exists. total sleep deprivation lifts mood in roughly 50-60% of depressed patients within hours, and it's gone after the first recovery sleep. adenosine accumulation, increased synaptic strength, a shift in default mode connectivity: all the things that normal sleep reverses. which means the depressive state is actively maintained rather than passively caused. something in ordinary sleep restores it every single night. not a protocol but if you've ever felt strangely clear after an all nighter and assumed you were broken, you're not.