MD | PhD | Autophagy, non-coding RNAs & epigenetics in cardiovascular medicine | @ipekresearch @dzhk_germany
Monaco di Baviera, Baviera
Joined March 2010
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Wow! Congrats @Y_Asare_ and friends for this amazing work! 😊
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Excited to share our latest study, published in @NatureComms, on X-linked lncRNA loci and their epigenetic signatures! Here we dissected the in vivo roles of Crossfirre, Firre, and Dxz4, exploring their potential impacts on imprinted & random XCI, as well as on autosomes 👇
Donato Santovito retweeted
Recruiting the next generation of medical students @ipekresearch @CRC1123_Athero today at the DoktaMed @LMU_Uniklinikum with @_LauraParma @5antus
Donato Santovito retweeted
We recruit Junior Group Leaders at the new Helmholtz-Institute for Translational AngioCardioscience (HI-TAC): 5+4 years. Work in the Heidelberg-Mannheim area in collaboration with the MDC Berlin! Apply now or latest Jan 6! application.mdc-berlin.de/si…
Donato Santovito retweeted
Brief Report: Neurodevelopmental Disorder Caused by Deletion of 𝘊𝘏𝘈𝘚𝘌𝘙𝘙, a lncRNA Gene nej.md/48gS1WY
Science behind the Study: Linking a Neurodevelopmental Disorder with a lncRNA Deletion nej.md/4hkctuu
#Genetics
ALT Panel A: Human chromosome 15q26.1, with a 500-kb inset showing a gene-sparse region upstream of the long noncoding RNA (lncRNA) CHASERR (teal) and its tandem coding gene CHD2 (light green). Panel B: Increased CHD2 protein abundance in induced pluripotent stem cells (iPSCs) from Patients 1 and 2, as compared with iPSCs from sex-matched wild-type controls, an unrelated female with CHD2 haploinsufficiency (CHD2+/−), and CHD2−/− CRISPR (clustered regularly interspaced short palindromic repeats)–Cas9 knockout iPSCs. Panel C: RNA sequencing in whole-blood samples, cultured fibroblasts, and iPSCs obtained from Patients 1 and 2 and cultured neural precursor cells obtained from Patient 1.
🔬New research from @ipekresearch
Here, we provide insights on the protective role of the RNA-binding protein MEX3A in human and mouse atherosclerosis.
@CRC1123_Athero @trr267 @CircAHA @dzhk_germany @YoungDZHK
Could Mex3a be the key to preventing atherosclerosis? New findings reveal its role in endothelial integrity and inflammation—could this RNA-binding protein be a new therapeutic target for CAD? @5antus @FlorianaFarina @ChenZhifen ahajournals.org/doi/full/10.…
Special thanks to @JamesHendo2021 @vastriantafyl @ChenZhifen @FlorianaFarina @RemcoMegens @YvonneDoring @Sattler_lab and all other (twitterless) friends and collaborators.
Donato Santovito retweeted
Today, we report a critical role for the ubiquitin-proteasome ⛓️🧵system in ferroptosis☠️- DDI2-mediated activation of NFE2L1 protects from cell death - important implications for proteostasis, cancer, and neurodegeneration - explore the ubiquitome!
👇
nature.com/articles/s41418-0… – at Munich, Germany
Donato Santovito retweeted
The Nobel Prize in Physiology or Medicine goes to #RNA biologists again this year!
In this case, I am glad that we added a small piece to the remarkable let-7 biology, highlighted in the cover story a few years ago:
sciencedirect.com/science/ar…
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Donato Santovito retweeted
To my Munich based tweeps:
Please join us for this FREE @FASEBorg Mini-Symposium on CVD and Cancer featuring @BernhagenLab @kistanford6 @5antus @Y_Asare_ et al. plus special insight sessions on how the FASEB Journals work! – at Munich, Bavaria
Donato Santovito retweeted
MicroRNA genes have evolved and expanded within the genomes of multicellular organisms for over 500 million years.
Today, we know that there are more than a thousand genes for different microRNAs in humans, and that gene regulation by microRNA – discovered by this year’s medicine laureates – is universal among multicellular organisms.
#NobelPrize
😊😊😊
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Donato Santovito retweeted
Passenger mutations in KO mice can alter nearby gene expression & affect experimental outcomes!
Inherited mutations, from donor strains, may lead to misleading phenotypes.
Always consider them in your study design!
Here is an example we just published:
tinyurl.com/ACKR1-KO
Donato Santovito retweeted
1/8 Grateful and happy that our new story on the mechanism of #stroke recurrence in the context of large-artery #atherosclerosis is out in @nature.
Big Thanks to our lab @ArthurLiesz @JiayuCao @ISD_Research and all esteemed authors to make it happen!
DOI: doi.org/10.1038/s41586-024-0…
ALT Murine Common Carotid Artery Atherothrombosis stained for Fibrinogen (red), Platelets (CD41, green) and Hoechst (Nucleus, blue).
Donato Santovito retweeted
Finally out today! Very proud of this story:
Innate immune memory after Stroke drives remote organ pathology
This study was led by superstar-postdoc @SimatsAlba and X-less Sijia Zhang. @CellCellPress
cell.com/cell/fulltext/S0092…
Donato Santovito retweeted
#OriginalResearch In response to hypoxia-driven autopahy ➡️ microvascular endothelial cells die while macrovascular endothelial cells proliferate ➡️ muscularisation of distal vessels and pulmonary hypertension @ShiauHaln ahajournals.org/doi/abs/10.1…
