I am a researcher working on the neural mechanisms of behavior at Massachusetts General Hospital.
Joined September 2013
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In intracranial surface grid recordings in 100 patient participants, connectivity and hyperexcitability differentiate tumor extent and brain tumor type including rel. to epilepsy and movement disorder cases
@MGBneurosurgery @MGHNeurology
@BWHNeurology medrxiv.org/content/10.64898…
Thanks to the massive and incredible team of neurologists, neuro oncologists, neurosurgeons, scientists, and engineers and especially the participants! It has been humbling and incredible.
@raslanneuro @RMarkRichardson @BrianNahed @MGBCTNS
Angelique C Paulk retweeted
Starting the new year off with our mini review on #glioma electrophysiology inspired by a #neurosurgery perspective. This was a fun one to write with a great team! 🧠
frontiersin.org/journals/onc…
Incredible effort from a massive team led by Charlie Windolf and Erdem Varol to develop DREDge motion correction algorithm of high resolution neural data across species including humans is finally out in Nature Methods! It was an honor to be involved! nature.com/articles/s41592-0…
Angelique C Paulk retweeted
Our language neuroscience lab (evlab.mit.edu) is looking for a new lab manager/FT RA to start in the summer. Apply here: tinyurl.com/3r346k66 We'll start reviewing apps in early Mar. (Unfortunately, MIT does not sponsor visas for these positions, but OPT works.)
Really enjoying the incredible talks at the MIT Neurotech 2024. Even more excited that the first two talks had shout outs to natural world utilized and inspired technologies from the ocean among incredible molecular and imaging advances. Neuroethology!
neurotech.mit.edu/
I got to talk about using human brain cell models from Neuromorpho.org to illustrate brain activity recorded with Neuropixels, thin film, and other microelectrodes. @NeuroMorphoOrg & researchers have provided incredible community resources! youtu.be/EZsNFi0XJJM?si=pqTD…
New perspective piece/review from @PeterNHadar, @ZelmannRina, @PariyaSalami, myself, and Syd Cash entitled "The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond": doi.org/10.3389/fnhum.2024.1…
Peter came up with a great title!
This article came together in 2 days, but it really was an accumulation of literature and years of observations of the brain in response to direct electrical stimulation, where we ask if it is moving toward a prescriptive therapy. @MGH_CNTR
Since 2016: I wrote 26 grants (22 as PI)
2019: 2 paradigm-shifting papers (tinyurl.com/3wmm79bk & tinyurl.com/2ehjmje2)
Since 2020: Inspired, propose using high resolution microelectrodes to study Cancer Neuroscience in vivo.
2024: Notice of Award for my first R01*!!
* notably after many attempts!!! There's too many people to thank, but I especially thank Sydney Cash lab at MGH, the Shadi Dayeh lab @UCSDJacobs , Drs. Gavin Dunn, Daniel Cahill, Ziv Williams, Isabel Arrillaga-Romany, and @MGHNeurology @MGHNeurosurg @MGH_CNTR @MGHNeuroSci !!!!
Angelique C Paulk retweeted
New TBS findings w/ iEEG by brilliant @YuhaoHuangMD! TBS → plasticity in minutes; DLPFC stim affects ACC; Connectivity predicts response! 🧠⚡️Opens new avenues for TBS optimization. More w/ TMS-iEEG, 3x TBS & units soon! Thanks @ACPaulk & team for collaborating 🙏 @StanfordBrain
Theta-burst stim (TBS) is used to treat depression, but how does it work? I dug into this question in my research yr with @DrCoreyKeller @ACPaulk, now out in @NatureComms, finding that TBS can produce plasticity-like changes in just minutes of stim. nature.com/articles/s41467-0…
Angelique C Paulk retweeted
Theta-burst stim (TBS) is used to treat depression, but how does it work? I dug into this question in my research yr with @DrCoreyKeller @ACPaulk, now out in @NatureComms, finding that TBS can produce plasticity-like changes in just minutes of stim. nature.com/articles/s41467-0…
Human brain responses to Theta burst stimulation can modulate with each stim! Incredible work from @YuhaoHuangMD, Cash lab, @KellerStanfordU , @DrCoreyKeller , and with help from our amazing patient participants! @MGH_CNTR @MGHNeurosurg @MGHNeurology @MGHNeuroSci Full thread:
Theta-burst stim (TBS) is used to treat depression, but how does it work? I dug into this question in my research yr with @DrCoreyKeller @ACPaulk, now out in @NatureComms, finding that TBS can produce plasticity-like changes in just minutes of stim. nature.com/articles/s41467-0…
Angelique C Paulk retweeted
Very proud of this one!!!! @Anth_Allam @SameerShethMD @abp4_ankit @NeuroPolarbear @BCMFromtheLabs @bcm_ocd @ Twitterless Sandy
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Angelique C Paulk retweeted
Excited to have our paper on semantic encoding during language comprehension out in Nature this week!
nature.com/articles/s41586-0…
It's exciting to attend my first Brain Initiative meeting and speak at the 10th Annual Brain Initiative Conference. All the neuroscientific work discussed here is so inspiring and motivating. The brain is so incredible! #BRAINConference #studyBRAIN @MGH_CNTR
Incredible work by Youngbin Tchoe, Shadi Dayeh, and team to make iEEG-microdisplays, thin film neural recording devices backed by tiny LEDs that light up to communicate brain activity, at Science Translational Medicine: science.org/doi/10.1126/scit…
w/ video! youtu.be/8JGHfXPbWCs?si=4WMm…
This was an amazing amount of effort which include multiple institutions and is described below. I was just happy to get to be a part of it. @MGH_CNTR @MGHNeuroSci @UCSDJacobs @UCSDNeuroSurg
today.ucsd.edu/story/a-flexi…
