A new study investigates how constitutive YAP activation in distal nephron segments alters epithelial identity and kidney structure, providing new insights into renal remodeling and disease. insight.jci.org/articles/vie…

Can red blood cells report endothelial health? This study shows that glycocalyx exchange between endothelial cells and erythrocytes enables a potential blood-based readout of endothelial function and vascular barrier integrity. nature.com/articles/s41467-0…

Injured epithelial cell states in kidney transplants persist beyond rejection and predict graft survival, shifting focus from immune cells to epithelial injury in transplant outcomes. nature.com/articles/s41467-0…

Single-cell multi-omics identifies endothelial PIEZO1 as a mechanosensitive driver of pulmonary fibrosis, acting through CAPN2/STAT3 to elevate IL-33 signaling—highlighting an ion channel as a therapeutic target nature.com/articles/s41467-0…

Proximal tubule cells show striking segment-specific lysosomal specialization, with distinct programs for protein vs lipid processing. nature.com/articles/s41467-0…

Can viral infection break epithelial barriers? This study shows that HCMV directly disrupts barrier function in cholangiocyte organoids and triggers EMT via TGF-β signaling. nature.com/articles/s41467-0…

Using in vivo dual RNA-seq, this study identifies critical host–pathogen interactions that drive epithelial barrier disruption, offering new insight into epithelial defense mechanisms. nature.com/articles/s41467-0…

How does tubular metabolism drive kidney fibrosis? This study uncovers a pyrimidinergic Ca²⁺ signaling pathway connecting metabolic stress in tubular epithelial cells to fibrotic remodeling. nature.com/articles/s41467-0…

How do epithelial cells precisely control ion and solute flux? New findings shed light on key regulatory mechanisms governing epithelial transport jci.org/articles/view/194762

How can metabolically demanding neural tissue survive without its own blood vessels — and without a vascular epithelium? This study shows that the avian inner retina relies on oxygen-free metabolism, revealing a remarkable epithelial–neural adaptation. nature.com/articles/s41586-0…

Pig kidney in humans? Immune profiling of the first living pig-to-human kidney transplant shows early T cell–mediated rejection and sustained innate immune responses, highlighting key barriers for successful xenotransplantation. nature.com/articles/s41591-0…

In kidney transplantation, epithelial injury matters! This study identifies persistent injured tubular epithelial cell states after T cell–mediated rejection that predict graft survival! nature.com/articles/s41467-0…

New human PTEC data show that hypoxia + IL-1 receptor signaling drives G2/M arrest and cellular senescence, highlighting an inflammation to senescence axis in maladaptive tubular repair after kidney injury. nature.com/articles/s41419-0…

A recent preprint presents intriguing findings about the lipid landscapes of apical versus basolateral membranes in epithelial cells, finding that they’re strikingly different. 📜 bit.ly/44hXgVU

A new JCI study has identified an alternatively spliced form of uromodulin (AS-UMOD) that appears during cellular stress and targets mitochondria to boost energy production and enhance cell survival📜 bit.ly/4ozntGD

Fresh week, fresh science! 🔬 Deep learning tools to analyse 14K+ glomeruli revealed a tight correlation between podocyte and parietal epithelial cells density. Check the paper in AJP Renal📜 bit.ly/4oBUEu0 #AJPRenal #CKD #glomeruli #podocyte

Your gut is an orchestra 🎻- and anion transporters are the conductors. A new review reveals how anion transporters (DRA, PAT1, CFTR) orchestrate the balance between ions, microbiota, and inflammation. 📜 journals.physiology.org/doi/…

Happy Friday! ☀️ Wondering how fluid flow shapes cell energy? A new paper finds LRRK2 guides mitochondrial positioning in developing kidney tubules - connecting mechanics to metabolism. 📜nature.com/articles/s41467-0… #mitochondria #LRRK2 #KidneyDevelopment

How do tissues feel and adapt to force? A new review explores how epithelia generate and respond to mechanical stress — from fluid pressure to the hidden mechanics of junctions and desmosomes. buff.ly/MpB6aXf

Apical trafficking breakdown can mimic Fanconi syndrome — and Syntaxin 3 appears central to keeping that system intact. Could reinforcing the SNARE complex be a future strategy to preserve tubular function? Check the latest paper📜bit.ly/43LjwqE #