@AdamEnglerUCSD

Husband | Dad | Bioengineering Professor & Chair of @ucsdbe | Cancer and Cardiovascular Mechanobiology | Assoc. Editor, @aplbioeng | he/him/his

 La Jolla, CA
ecm.ucsd.edu
Joined June 2014
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  • Followers4K
312Media
WE HAVE A NEW NAME!!!!! Thanks to @UCSDJacobs, @ucsdbe, and all of our amazing staff, students, and faculty. Thank you to Shu Chien for his leadership, and especially @BioLegend CEO Gene Lay for this transformational gift.
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New paper in @NatureComms! We developed Primer PICKR, a literature-mined database of qPCR primers that we hope makes assay design less painful. Why do we need this? Every lab wastes time and reagents ordering primer pairs that don't amplify. nature.com/articles/s41467-0…

Primer PICKR: literature-mined scoring platform for robust RT–qPCR primers

Nature Communications - Reverse transcription PCR is widely used but often suffers from unreliable primer selection. Here, the authors introduce Primer PICKR, a database that ranks primers using...

nature.com
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By combining literature evidence, biophysical fit, and pair synergy. The result is 355,000 scored primer pairs across 31,000 genes, all free and searchable at primerpickr.com
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Thanks @Abhinaba_UCSD, Tom Molley, and Alis Balayan for leading the effort at @ucsdbe and @ucsdjacobs. Thanks to @NIH for making this tool possible.
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Calling all alumni and friends to support our @ucsdbe and @UCSDJacobs students on April 29th! The first $10K raised will be matched by our BE Alumni Board!! giving.ucsd.edu/BEalumni #tritongivingday #tritonalumni #bioengineering
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🔱🔱Excited to share the winter newsletter from @ucsdbe and @UCSDJacobs! Check out major research accomplishments, major gifts from alumni and friends, and more!🔱🔱 t.e2ma.net/message/i1tish/e2…
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🎉🎉🎉 So happy to celebrate with Dr. Shu Chien and Dr. Kuang-Chung (K-C) Chien! 🎉🎉🎉 Their recent gift supports our new Bioengineering Instructional Lab, and it names the Dr. Kuang-Chung Chien Tissue Culture Room.
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From the photos, it would seem that K-C hasn't lost her pipetting skills! Perhaps we found a new instructor for the BENG158 lab? Thanks to @UCSDJacobs, our Chien-Lay Department of Bioengineering staff (@ucsdbe), and good luck to our students in their lab classes.
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🎁Need some holiday reading???? 🎁 Check out our lab's latest oral #cancer work showing that #stiffness-induced mesenchymal cells use #paracrine #signaling to "educate" their neighbors. See the paper here: pubs.aip.org/aip/apb/article…

Stiffness-mediated paracrine signaling enhances induction of EMT in oral squamous cell carcinoma

Oral Squamous Cell Carcinoma (OSCC) contains diverse communities of cells within the oral mucosa. A subset of the epithelia is highly responsive to changing nic

pubs.aip.org
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Together, the cells cooperatively migrate, especially in the context of oral cancer (#OSCC). Thanks to first author So Youn Moon for her great skills in identifying these signaling interactions and to our long-time collaborator Marcelo Lamers at @ufrgsnoticias
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Thanks as well to @theNCI for funding this understudied tumor type!
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👇👇👇👇Just Released👇👇👇👇 The 2025 Impact Report for @UCSDJacobs's Chien-Lay Department of #Bioengineering is out!!!! Amazing updates from @ucsdbe students, faculty, and staff. #TritonPride heyzine.com/flip-book/93cd25…

UC San Diego Chien - Lay Department of Bioengineering

Created with the Heyzine flipbook maker

heyzine.com
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Thanks to our faculty contributors: @ChristmanLab, @ContijochResLab, @StimulatedRaman, @reemkhojah, @FraleyLab, @esterjkwon, @KunZhangBioE, @kiana_aran, @ChapelinFanny, @ELCyphert_PhD, @KnightLabNews, @KravetsVira, @prashantgmali, and more!
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🎉Just published a cool story in @NatureCellBio with @dtschump1 (@MayoClinic ) and @david_lagares (@harvardmed and Zenon Biotech) on #durotaxis. nature.com/articles/s41556-0… (1/4)

Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic...

Nature Cell Biology - Al-Hilal, Chrysovergi et al. identify a role for durotaxis in lung fibrosis and metastatic pancreatic cancer, mediated by the FAK–paxillin mechanosensor complex, and...

nature.com
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Disruption of this pathway through genetic or pharmacological inhibition blocks durotaxis and attenuates disease severity, highlighting anti-durotactic therapy as a promising treatment strategy. (3/4)
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Thanks to Cassie Happe and Ludovic Vincent from @UCSDJacobs and @ucsdbe for the help over many years to make the durotactic substrates used in the paper. Many, many others to thanks, especially @NIH for funding. (4/4)
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#ICYMI: Very cook iPSC-organoid paper to create an engineered neural progenitor cell niche. Via @unifesp and Marimelia Porcionatto's lab in @aplbioeng: pubs.aip.org/aip/apb/article…

3D bioprinted human iPSC-derived neural progenitor cells as a novel platform for studying neuroge...

Animal models, especially rodents, used to study neurodevelopment have significantly advanced our comprehension of cellular and molecular mechanisms. Neverthele

pubs.aip.org
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Registration is now open for the inaugural Female Athlete Research Meeting (FARM) at Stanford! Spots are limited. Join us on Nov. 5, 2025, for a day dedicated to advancing women & girls in sport through research, collaboration, & innovation. #FARM2025 humanperformance.stanford.ed…
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New article online: Trionic all-optical biological voltage sensing via quantum statistics. bit.ly/4l5yqOY
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