Nephrologist, physician-scientist. Director, Division of Nephrology, Jared Grantham Kidney Institute, University of Kansas @KUNeph Opinions are my own
Kansas City, KS
Joined February 2009
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Alan Yu🇭🇰 retweeted
New in #ASNJASN and simultaneously published with #KidneyWk: Study found empagliflozin 25 mg once daily for 12 months was safe & well-tolerated in adults with ADPKD at high risk for rapid progression. Those treated with empagliflozin had greater increase in kidney volume kidney.pub/JASN1271
Alan Yu🇭🇰 retweeted
Stronger together!!! Excellent day with The PKD RRC team at ASN kidney week. @American society of Nephrology @pkdresearch
Alan Yu🇭🇰 retweeted
Basic Research published in #ASNJASN identified a protein called ARL13B that helps drive cyst growth in polycystic kidney disease. In mice, blocking this protein reduced cyst growth and improved kidney health, suggesting it could be a possible target for future treatments. kidney.pub/JASN1238
Alan Yu🇭🇰 retweeted
New research published in #ASNJASN helps explain why people with chronic kidney disease are more prone to blood clots and points to a potential new target for preventing these serious complications. kidney.pub/JASN1203
Alan Yu🇭🇰 retweeted
Could a novel CHAR T-cell therapy provide a targeted way to desensitize kidney transplant candidates with HLA-DQ antibodies? Read #BasicResearch #ASNJASN to find out. kidney.pub/JASN1244
Alan Yu🇭🇰 retweeted
Huge disappointment. High hopes...dashed
Following a recommendation from the DMD Boehringer Ingelheim has decided to discontinue the EASi-KIDNEY trial (NCT06531824)
Testing vicadrostat (BI 690517), in combination with empagliflozin vs empagliflozin alone, could slow CKD and ⬇️ CV events
boehringer-ingelheim.com/hum…
Alan Yu🇭🇰 retweeted
Some people with HIV who carry high-risk APOL1 genes may be less likely to develop kidney disease if they also have the APOL1 p.N264K genetic variant. This finding in #ASNJASN may help doctors better understand an individual's kidney disease risk in the future. kidney.pub/JASN1235
Alan Yu🇭🇰 retweeted
🏆 Lillian Jean Kaplan Prize for PKD: Feng Qian. Learn more: bit.ly/4xANJpj
“I am deeply honored and humbled to receive the Lillian Jean Kaplan International Prize. This recognition reflects the collective efforts of many outstanding colleagues, trainees, collaborators, and patients whose contributions have advanced our understanding of polycystic kidney disease. While significant progress has been made, important challenges remain. I look forward to continuing the pursuit of discoveries that deepen our understanding of PKD and ultimately improve the lives of patients and families affected by this disease.” Prof. Qian
Guideline is based on primary outcome of TKV growth in HALT trial, which was sig lower in the low BP group, and on post-hoc analysis of chronic GFR slope, which was borderline significantly reduced. The rating of evidence (D) looks right.
Alan Yu🇭🇰 retweeted
Measuring slit diaphragm autoantibodies could transform care by distinguishing low-risk from high-risk autoimmune podocytopathies, improving prognosis, treatment selection, and transplant planning, according to new study in #ASNJASN. kidney.pub/JASN1195
Alan Yu🇭🇰 retweeted
APOL1 risk variants (G1/G2) form membrane pores that increase Ca²⁺ influx and kidney cell damage. The APOL1 inhibitor VX-147 and the M1 (N264K) variant reduced Ca²⁺ entry and improved cell survival, highlighting potential therapies for APOL1 kidney disease. #ASNJASN kidney.pub/JASN1159?utm_sour…
Alan Yu🇭🇰 retweeted
#BasicResearch study in #ASNJASN shows that blocking gut microbial TMAO production reversed key features of established CKD in mice, further implicating the gut-kidney axis as a promising therapeutic target. kidney.pub/JASN1171?utm_sour…
Alan Yu🇭🇰 retweeted
Our new study in @JASN_News: Autoantibody specificity matters: anti-nephrin, anti-podocin, and anti-KIRREL1 antibodies define autoimmune podocytopathies with distinct phenotypes, prognosis, and transplant recurrence risk. ovid.com/jnls/jasn/abstract/…
Alan Yu🇭🇰 retweeted
But @kidney_boy does! It’s all about a low urine output for a bit!
