@Ale_LopezCruz

Neuroscience postdoc at Knight Lab @UCSF | Assistant Adjunct Professor @UCSF | HHMI Hanna Gray Fellow | 🇵🇷

 San Francisco, CA
Joined November 2024
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  • Following222
  • Followers96
Alejandro Lopez Cruz retweeted
Natalie Figueredo Burgos@Naty_Figueredo_Jul 8
📣 Really excited to share our new preprint! 🎉 biorxiv.org/content/10.64898… In this study, we dissect the roles of GIPR neurons in two adjacent brainstem nuclei, the area postrema (AP) and nucleus tractus solitarius (NTS), and show that they have opposing effects on feeding.

Opposing GIPR brainstem circuits differentially control feeding behaviour

Central glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling is required for the efficacy of GIP-based obesity therapeutics, yet how distinct subpopulations of GIPR neurons shape...

biorxiv.org
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Excited to share a preprint of my postdoc work in the @zaknight lab! We recorded the natural activity of neurons in the brain's "nausea center", the area postrema (AP), including the direct targets of major weight loss drugs like semaglutide. biorxiv.org/content/10.64898…

Functional segregation of body-brain signals in the area postrema

Nausea arises from activation of specialized neurons in the area postrema (AP)[1][1]–[8][2]. The AP also mediates much of the satiety produced by GLP1R agonists[9][3]–[12][4], suggesting a broader...

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What we found: 🟠GFRAL neurons: activated by emetics and dietary fat ⚪️GIPR neurons: activated by sugar, possibly gate GFRAL activity 🔵CALCR neurons: track intestinal osmolarity and distension to pace meals 🟢PRLHR neurons: track blood volume/pressure
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The big picture: Genetically-defined AP cell types delineate separate pathways for sensing and responding to a broad range of physiologic stimuli, most unrelated to sickness and aversion.
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Alejandro Lopez Cruz retweeted
Leslie Vosshall PhD
@leslievosshallMar 28
Join us in shaping the future of science! @hhmi_science is hiring a new Scientific Program Officer to support the #HannaGrayFellows #FHScholar programs hhmi.wd1.myworkdayjobs.com/e…
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Alejandro Lopez Cruz retweeted
Nancy Padilla Coreano@DrNancyPadillaMar 20
My lab is hiring a technician at @UFNeuroscience! 🧠🐭 We use in vivo ephys, optogenetics & machine learning to study how the brain controls social behavior in mice. Looking for rodent research & mentorship experience — please repost & share! Apply here: forms.gle/VACAMuoaRbWRG7tp9
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Alejandro Lopez Cruz retweeted
Zachary Knight@zaknightMar 20
We have an opening for a Lab Manager position in my group at UCSF. Consider joining us! Link in reply.
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Alejandro Lopez Cruz retweeted
UCSF Postdoc Office@UCSF_Postdocs15 Jan 2025
Last week, @HHMINEWS announced the 2024 Hanna H. Gray Fellows! We're proud of our two current @UCSF postdocs @Ale_LopezCruz & @JoseAVelilla2 who join 25 exceptional early career scientists with this achievement. 👏 Learn more about the announcement: tiny.ucsf.edu/hhmihannahgray…
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Thrilled to share that I'm joining the new cohort of @HHMINews Hanna Gray Fellows! 😀I'm so excited and grateful to join this amazing community of scientists. Thanks to my mentor @zaknight for his support!
HHMI
@hhmi_science8 Jan 2025
Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists! This cohort includes scientists working in research areas ranging from treatment-resistant cancers to sleep dysregulation to how animals evolved to live on land. Read more about HHMI’s Hanna Gray Fellows Program: hhmi.news/4gIsZU5
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