@AlexWGuyon

PhD student in the Schornack Group @slcuplants. Interested in conserved components of plant-microbe interfaces

slcu.cam.ac.uk/people/alex-guyon
Joined March 2020
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Thus concludes the 2026 edition of the Norwich-Cambridge Science Symposium (NoCaSS). A celebration of all the amazing research happening across institutes. Made some great connections and got to present my research again! Very happy. Look forward to the next! 🌱
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Nicotiana benthamiana cortical cell (magenta) packed with a mature arbuscule (yellow). The subtle space in the middle is, presumably, where the plant's nucleus ended up while accomodating its fungal partner! #AMF #mycorrhizae #symbiosis #plantscience
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Alex Guyon retweeted
Alain Tissier@trichomeIPBJul 29
Our preprint is now peer-review published with additional data, including transcriptomics, giving us hints about the molecular basis of de novo trichome induction in N. benthamiana. Check it out here: cell.com/plant-communication…

Cytokinin-mediated trichome initiation in Nicotiana benthamiana following Agrobacterium tumefaciens...

Agrobacterium tumefaciens is widely used in plant genetic engineering owing to its tumor-inducing (Ti) plasmid, which contains a transferable T-DNA region and a virulence (vir) region encoding a type...

cell.com
Alain Tissier@trichomeIPB19 Dec 2025
Attention Nicotiana benthamiana users! Certain strains of Agrobacterium induce glandular trichomes because of cytokinin production by Agrobacterium. As this can influence assay outcome, we recommend testing several strains. See our preprint: biorxiv.org/content/10.1101/…

Cytokinin-mediated trichome initiation in Nicotiana benthamiana upon Agrobacterium tumefaciens...

Infiltration of Agrobacterium tumefaciens in leaves of Nicotiana benthamiana has become a standard method for transient expression in plants. Like many Solanaceae species, N. benthamiana develops on...

biorxiv.org
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Sebastian Schornack @dromius from @slcuplants is now chairing/presenting their exciting work led by @AlexWGuyon on phospholipid signatures at plant-microbe interfaces. Check out the paper here: doi.org/10.1016/j.celrep.202…
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Growing love - when a root meets a symbiotic #Mycorrhiza #fungus See what happens with MycorRhize3D. schornacklabslcu.github.io/M… It simulates a tap root in soil with spores. The root turns red when colonised, just like in this paper journals.plos.org/plosbiolog… Reply for suggestions!
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Great to see this work out, congratulations!
Sebastian Schornack@dromiusJul 13
How do "friendly" rhizobia build a legume nodule? @AlbinTeulet found that some may carry hidden transcription factors - proteins that mimic DNA-binding folds to enter the plant nucleus and rewrite its developmental program. biorxiv.org/content/10.64898… (1/6)
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The 'heart' of the #Mycorrhiza #fungi #symbiosis is the arbuscule where plant and fungus exchange nutrients and carbon. Try the arbuscule growth simulator. Let me know how you adjust parameters to get the most beautiful arbuscules. SchornackLabSLCU.github.io/A…
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Congratulations, very cool story!
Diana Gómez De La Cruz@dianagdlcJun 5
So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵and link to the original preprint thread👇 science.org/doi/10.1126/scie…

Molecular mimicry of a pathogen virulence target by a plant immune receptor

Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect...

science.org
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Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇 biorxiv.org/content/10.64898…
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📢 2 PhD Positions - Plant Immune Receptor Bioengineering at Imperial College London 🌱 Start: Oct 2026 📅 Deadline: 10 Feb 2026 🇬🇧 UK/settled status only 💰 Fully funded (48 months) ℹ️ shorturl.at/po61I #PlantImmunity #PlantPathology 🙏 Share with interested candidates!
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New opportunity to join our #EvoMPMI group @JohnInnesCentre as a Postdoctoral Researcher working in the mechanistic basis of immunity in diverse plants. Please spread the word, reach out by email, and/or apply if interested! More details here: jic.ac.uk/vacancies/postdoct…
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Very exciting to see my first, first author paper out now. Many thanks to my co-authors for all their hard work and support on this project!
Sebastian Schornack@dromius11 Dec 2025
Mycorrhiza symbiosis changes how plants interact with intracellular pathogens. New by @AlexWGuyon, @TheresaStaps, and Lyne Badot: Mutualist-pathogen co-colonization modulates phosphoinositide signatures at host intracellular interfaces sciencedirect.com/science/ar… Read further ⬇️
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Excited to share the publication of our latest ‘Commentary’ article : "Metabolic Detour, Symbiotic Delay: Insights from Sinorhizobium meliloti Suppressor Mutants" doi.org/10.1094/MPMI-07-25-0… @slcuplants @MPMIjournal
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#2025ISMPMI check out our finest selection of posters on symbiosis, effectors, Marchantia and barley. @IamJawaharSingh @AlbinTeulet @kos_darius @Rochirmayi
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Thrilled to share our latest @biorxivpreprint! This work started during my PhD and was finished together with @JMadhuprakash. We found a Phytophthora infestans L-shaped effector that bridges a host TOL protein to activated NLRs to suppress immunity! biorxiv.org/content/10.1101/… 1/15
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Congrats to @_chetan_pandey_ @slcuplants for his Best Poster Award. Very proud of you!
Alex Guyon@AlexWGuyon4 Jul 2025
Congratulations to @_chetan_pandey_ for winning the best poster at Botanicon 2025!
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Congratulations to @_chetan_pandey_ for winning the best poster at Botanicon 2025!
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Alex is talking about his phosphoinositides @AlexWGuyon – at Cambridge, England
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7/ So what's going on? We propose that PI4P exclusion from haustoria is a pathogen-driven strategy, likely involving secreted effectors. But during AM symbiosis, trafficking to arbuscules may override this, forcing the pathogen into an interface it didn’t design.
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8/ Beyond just documenting these dynamics, our work asks: 🌱Can we rethink host-pathogen “specialised” membranes as dynamic, context-dependent landscapes? 🔬Are immune evasion strategies vulnerable in complex microbial environments?
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8/ TL;DR: ✅ Phosphoinositide signatures at plant-microbe interfaces are dynamic ✅ Mutualist colonisation reshapes pathogen interface identity ✅ This shift correlates with enhanced resistance, suggesting membrane identity may influence infection outcome.
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