Alex Walker (@AlexWalkerPath) header
Alex Walker (@AlexWalkerPath) profile picture

Alex Walker

@AlexWalkerPath

Postdoc with @PeterJCullen @BristolBiochem, formerly postdoc @YamauchiLab @CMMBristol and DPhil Student @fodorlab @Dunn_School. Biology 🦠🧬 and food! 🍕🥐

Joined August 2019
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Really glad to contribute to this work led by the crazy-talented (although not on social media!) Rebeka Butkovic 🎉 An exciting first step into the fascinating world of cell biology! 🧪🧫
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Ready for #NSV2022 after a cancelled flight led to an unexpected journey to Heathrow airport! ✈️ Excited to catch up with old friends and make some new ones!
Image from Alex Walker (@AlexWalkerPath)
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Just out today, our contribution to understanding #SARSCoV2! We show that the viral polymerase is involved in capping the viral RNA. With thanks to @fodorlab @haitian_fan @JeremyKeown1 @M_L_Knight @jonathan_grimes academic.oup.com/nar/advance…
The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme

The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme

Abstract. SARS-CoV-2 is a positive-sense RNA virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic, which continues to cause significant m

academic.oup.com
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New preprint alert 🚨 Our latest SARS-CoV-2 work, showing that one of the domains in the viral RNA polymerase is an enzyme involved in viral RNA capping (and this reaction is inhibited by remdesivir TP)!
Fodor Laboratory (@fodorlab) profile pictureFodor Laboratory@fodorlab18 Mar 2021
Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase disq.us/t/3vmk30i
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We present the first structures of influenza virus polymerase bound to an essential host factor, and these give us some amazing insights into how the #flu virus replicates/adapts for new hosts! Congratulations everyone @CarriqueLoic @haitian_fan @JeremyKeown1 @jonathan_grimes
Jeremy Keown (@JeremyKeown1) profile pictureJeremy Keown@JeremyKeown118 Nov 2020
nature.com/articles/s41586-0… @CarriqueLoic @haitian_fan @AlexWalkerPath @jonathan_grimes #notontwitterErvin. We solved a series of structures using #cryoEM of the ANP32-Influenza polymerase complex, and investigated it using functional assays. @OxfordStrubi @Dunn_School @NDMOxford
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We've updated our paper to include data on the ability of remdesivir and favipiravir to inhibit SARS-CoV-2 polymerase. A metabolite of the drug enisamium has similar inhibitory activity to remdesivir! @aj_velthuis @haitian_fan @JeremyKeown1 @Dunn_School biorxiv.org/content/10.1101/…
Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases

Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases

Influenza A virus and coronavirus strains cause a mild to severe respiratory disease that can result in death. Although vaccines exist against circulating influenza A viruses, such vaccines are...

biorxiv.org
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New pre-print from our lab and @aj_velthuis! We show that an anti-flu drug, enisamium, inhibits the RNA polymerases of both influenza and SARS-CoV-2 @haitian_fan @JeremyKeown1 @jonathan_grimes biorxiv.org/content/10.1101/…
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Our new paper is out! We find that the influenza virus polymerase has an RNA binding site required for elongation in viral transcription. Several other viral polymerases have a similar site - conserved mechanism? Take a look! jvi.asm.org/content/early/20…
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Our lab is looking for a post doc to work on flu virus! Can't recommend the lab highly enough, it's a great place to work and do some top notch science
Michael Knight (@M_L_Knight) profile pictureMichael Knight@M_L_Knight24 Feb 2020
Post doc position available in our (Ervin Fodors) lab. A chance to work with a great group of people and do exciting science! my.corehr.com/pls/uoxrecruit…
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This hits home
Nathan W Pyle (@nathanwpyle) profile pictureNathan W Pyle
@nathanwpyle25 Sep 2019
Image from Nathan W Pyle (@nathanwpyle)
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Our paper came out today! New flu polymerase structures, and the function of polymerase dimerisation in viral genome replication. Congratulations @haitian_fan @CarriqueLoic @JeremyKeown1! nature.com/articles/s41586-0…
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New studies are revealing an increasingly intimate interaction between influenza virus polymerase and RNA polymerase II, summarised exquisitely in this review (may be slightly biased since I wrote it!)
Trends in Microbiology (@TrendsMicrobiol) profile pictureTrends in Microbiology@TrendsMicrobiol23 Apr 2019
Interplay between influenza virus and the host RNA polymerase II transcriptional machinery ow.ly/1FOx50rkU1V
Image from Trends in Microbiology (@TrendsMicrobiol)
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