@AllbridgeCap

Backing ambition.

 Australia
Joined November 2016
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From updated preprint co-authored by @US_FDA scientists, re: @MolecularPrtnrs @Novartis DARPin antiviral ensovibep "retain inhibitory potency against all frequent SARS-CoV-2 variants, including Omicron BA.1 and BA.2, as of February 2022." biorxiv.org/content/10.1101/…
Shai Biran@ShaiBiran28 Feb 2022
For those following our #covid19 program, we have recently updated ourbioRxiv with data showing ensovibep remains fully active against Omicron BA.2 too - biorxiv.org/content/10.1101/…

Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variants

SARS-CoV-2 has infected millions of people globally and continues to undergo evolution. Emerging variants can be partially resistant to vaccine induced immunity and therapeutic antibodies, emphasiz...

biorxiv.org
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Excellent speech by the President of Ukraine to the people of Russia. One for the history books.

President Zelenskyy's speech to the Russian people

Ukrainian President Volodymyr Zelenskyy's plea to the Russian people in video remarks posted early on Feb. 24 local time with English subtitles.

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This is not good news #covid19 #sotrovimab #OmicronVariant
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Ensovibep is designed to simultaneously bind the #COVID19 virus in 3 places. We recently shared positive results from our global study of ensovibep in patients demonstrating 78% reduction of the risk of hospitalization, emergency room visits, or death: bit.ly/3tfS6b3
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If Pfizer hits the $22B in paxlovid number this year, it will likely make it (no surprise) the largest selling drug in the world. Humira did $20.7B in 2021.
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”This indicates that epithelial cell intrinsic antiviral responses are insufficient for the clearance of SARS-CoV-2, implying an essential role for tissue-resident and infiltrating immune cells for eventual viral clearance from infected airway tissue” journals.asm.org/doi/10.1128…
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COVID-19 can cause lasting damage to the cardiovascular system, even in “mild” cases that didn’t require hospitalisation during the acute phase of infection. A new study shows we’re going to see more heart disease, strokes, blood clots & other problems.🧵 nature.com/articles/s41591-0…
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FY22 guidance exclusing any revenue from pot. APAs for $MOLN ensovibep, $NVS CEO confirming discussions with governments and "interested parties" though, probably more info later in Q1 or Q2
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allbridge retweeted
UZH Alumni@uzhalumni4 Feb 2022
💡Public lecture: Ensovibep – a journey from basic research to the development of a promising Covid-19 drug 📅 8.2.2022, 12 p.m., on Zoom 👨‍🔬 Andreas Plückthun, Professor for Biochemistry at @UZH_ch & Michael Tobias Stumpp, co-founder of @MolecularPrtnrs uzhalumni.ch/events/78415
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allbridge retweeted
Eric Topol
@EricTopol3 Feb 2022
The countries that will not reach 70% 2-shot vaccinated by mid-2022. One is the 3rd largest in population and among the richest in the world
Edouard Mathieu@redouad3 Feb 2022
Update: We now project that 122 countries – including Bangladesh, Egypt, Ethiopia, Nigeria, Pakistan, Russia, and the United States – are not on track for the WHO's target of 70% of the population fully vaccinated by mid-2022. Read more: ourworldindata.org/covid-vac…
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Replying to @Comm_Invest
Wonder who the natural buyer is....
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Bloody hell, isn't anyone at #npc aware of TGA boss statement that they were "waiting for a signal " from the government last year?
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Replying to @barriecassidy
“I can’t give you a specific date yet,” Mr Morrison told radio 4CA in Cairns, “and that’s because we’re just watching how omicron is sort of washing over the eastern states at the moment.” “Sort of washing over” “Just watching”…
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Inflation Will Hurt Both Stocks & Bonds by @Nouriel The negative correlation btw stock & bond prices comes from the low-inflation of the past. If inflation remains high, investors will have to rethink their portfolios 2 hedge against risk of large losses. prosyn.org/6kBeLXg?referral=…
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Dogs.
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Stealth Omicron: AKA BA2 sub-linage:if there was one good thing about Omicron it was that it was easy to detect: and I mean that was about the only thing that was good: and now it's not...and stealth is more infectious and looks to be more severe as well forbes.com/sites/roberthart/…
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An important and informative thread #COVID19
Dr. Deepti Gurdasani@dgurdasani128 Jan 2022
Really worried about the direction things are moving in globally. BA.2 and BA.1.1. seem to be sweeping to dominance in different regions rapidly. Pandemic growth has also resumed in many places including England, & more recently Gauteng. A thread looking at the current evidence.
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Overall, this isn't good- what we're seeing is rapid adaptation, and emergency of sublineages, fitter than the original, which means it becomes very hard to contain the pandemic, as the virus gets fitter. Bizarrely we're easing mitigations in England in the middle of this!
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Bernanke's response above was to this: "Fisher said that he had recently spoken with the chief financial officer of Texas Instruments, who explained how the company was managing money in the age of ZIRP...'I’m not going to use it to create a single job'" goodreads.com/book/show/5848…
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The penny is starting to drop in the press gallery. Now have a look at Victoria. Don’t rely on precedents. There is something brand new stirring this time.
Quentin Dempster
@QuentinDempster28 Jan 2022
⁦@spenderallegra⁩ & ⁦@KyleaTink⁩ are pulling primary votes in Wentworth & North Sydney according to ⁦@PhillipCoorey⁩ ⁦@FinancialReview⁩ based on UComms poll. Sharma/Zimmerman in deep doo doo. If only they’d used their party room leverage on climate change!
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