Manchester Biochemist. Founder of PharmaKure. Author of "This Mortal Coil. A History of Death". Runner, climber, quizzer.

United Kingdom
Joined January 2019
Andrew Doig retweeted
An oldie but a goodie. In 1968 a bunch of entitled hippy bastards sent a letter detailing their specious demands to the Warden and Fellows of Wadham College, Oxford. This was their letter of reply, which speaks to how far the academy has since fallen.
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Andrew Doig retweeted
Google Deepmind just broke chemistry.. They open-sourced a model that can invent completely new biology from scratch. It’s called “AlphaProtein Novo” It's an AI pipeline that designs brand new enzymes for "new-to-nature" chemical reactions that have never existed in any living organism. to put this in perspective.. standard protein ai models (like alphafold) answer the question "what shape will this protein have?". ap novo answers the question "can i make a protein that does this specific chemistry?". the results from the paper are actually terrifyingly good: the ai designed an enzyme to synthesize piperidines, which are a critical building block used in pharmaceuticals and materials. this designed enzyme inverted natural biases to achieve near-perfect regioselectivity. it produced the chemical building block 99x more often than the competing natural product. it also designed an enzyme to hydrolyze DEHP, which is a pervasive plastic environmental toxin. this plastic-eating ai enzyme was 14-fold more active at 90°C than at room temperature, and survived in 75% acetonitrile. meanwhile, natural enzymes completely failed and were entirely inactive under those exact same extreme conditions. these new ai-generated designs are up to 60% smaller than natural equivalents. because they are smaller, they have a much higher mass density of active sites. i am speechless.. this is the holy grail of synthetic biology. we don't have to wait millions of years for microbes to evolve enzymes that eat our pollution or build our drugs.. we can just compute them on a gpu today. the ai's success rate in finding functional designs actually matches or surpasses traditional natural sequence screening. and deepmind open-sourced the whole thing on github.
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Replying to @simongerman600
Rave in Mongolia. Watch until the camera moves away from the DJ... xitter.cf/Underbelly2_0/status/1…
In Mongolia The Horses Rave With You 😎😂🤣
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King’s College London is pressing ahead with a centrally driven overhaul of teaching and assessment across the university under an EDI framework centred on “inclusive marking” and “decolonising” the curriculum. Internal documents seen by the Committee for Academic Freedom (CAF) suggest the scale of change is far greater than previously understood, raising serious questions about #academicfreedom. Full story 👇
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The 1979 Islamic Revolution was as world-changing a revolution as those of France in 1789 and Russia in 1917 and the fall of the Soviet Union in 1991, heralding a new era of Islamist mobilization across the entire Middle East that promoted a Sunni as well as Shiite radicalization as well as establishing a theo-monarchical dictatorship and a repressive Iranian state hostile to America and Israel and later forging an informal (and shortlived) Iranian empire – sometimes known as the ‘Shiite crescent.’ An Iranian Revolution in 2026 will be just as momentous = a decisive world changing event as important as 1789, 1917, 1979 and 1991. It is one that would resonate across the world, leading to other revolutions: Prince Metternich said ‘when France sneezes, the rest of Europe catches cold” meaning that when a revolution struck Paris, the whole of Europe shook. Repeatedly revolutions in France sparked revolutions all over Europe – particularly in 1848. In the so called Arab Spring of 2011, we saw a similar phenomenum when a revolution in Tunisia spread to Egypt, the most populous Arab state, and that led to protests all over the region including in Iran. Just as the Khomeini revolution of 1979 sparked Islamist violence all over the Middle East so its downfall in 2026 would rebound in all sorts of unexpected ways and would not only completely change the geopolitics of the Middle East – a process that has already started – but would lead to revolutions elsewhere too. It would be a boost to the Open World of the liberal democracies, a blow to China-Russia’s Closed World and the infection of revolution could spread across hemispheres. Would it spark revolution in the already-flimsy Castroista Communist regime in Cuba which is bankrupt and sclerotic? Would it lead to protests against the Turkish Sunni Islamist autocracy of President Erdogan which is unpopular and increasingly repressive even as, like Iran a few ago, it enjoys success abroad? What if it spread to Russia? That will certainly on Vladimir Putin’s mind. He has also faced the threat of popular protests against his dictatorship and he himself was threatened by the sight of the Libyan ruler Muammar Kadaffi being lynched and killed on camera and that of another ally, Bashar Assad, would spark revolutions against autocrats that could spread to Russia. It was one of the reasons he intervened to save Assad in Syria, an intervention that he launched in conjunction with Iran and its vassal militia, Hezbollah and one that saved the Assad dynasty for several years. As momentous as any of these richochets, the greatest could be this: after the failure of the Islamist paradigm, from the long disaster of Iranian dictatorship and its proxy vassals Hamas and Hezbollah, this may also end this era of Islamism or at least diminish its allure.
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🚨🇮🇷 Meanwhile in Iran There is a massive revolution going on across a run right now against the Islamic regime in power. However, for some bizarre reason, most legacy fake news media outlets including the BBC are simply refusing to report on it!
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"What Americans in a 1998 poll expected to happen by the year 2025..."
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During the Covid lockdown, if you had family round on Christmas Day, police could force entry to your home and make them go home. Does anyone know if this is service is still available, and if you have to book?
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Over 600 scholars have now signed the open letter condemning the campaign against Professor Michael Ben-Gad and supporting his personal and intellectual freedom as an academic. Credit to colleagues at @AFAF_freespeech and the London Universities’ Council for Academic Freedom (LUCAF) for their work behind the scenes in building support and getting the letter up and running. Read and add your name here: docs.google.com/forms/d/e/1F… Full story here: afcomm.org.uk/2025/10/20/jew…
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Today I finished 18 weeks of chemotherapy, brachytherapy surgery and 4 weeks of chemotherapy. Many thanks to the staff at St James’s Hospital Leeds and the Huddersfield Royal Infirmary, as well as the scientists, companies and charities who made such brilliant treatments possible
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This is what I came to the internet for
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There are not many places on earth where we have detailed cause-of-death data from before the era of widespread vaccination. Massachusetts is one of those places. From 1842-1877, 70% of all deaths were from diseases which we today have vaccines to prevent.
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Three-year-old Anish Sarker from India has become the youngest FIDE-rated chess player in the world, with a rating of 1555 xitter.cf/DamnThatsInter/status/…
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It seems timely to repost one of my favourite tables: cdc.gov/vaccines/imz-manager…
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Andrew Doig retweeted
Robert Plant
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Andrew Doig retweeted
At the weekend, we reached 100 million 5k parkruns 🎊 That’s equivalent to our first parkrun, which had 13 finishers, being repeated 7.7 million times! 🌳 #loveparkrun
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Andrew Doig retweeted
Estimates of number of lives saved: -Bosch and Haber (synthetic nitrogen) over 2 BN -Landsteiner and Lewisohn (blood transfusion) over 1 BN -Borlaug (wheat varieties) over 200 M 🫡
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