@AndyRusss

Postdoctoral Fellow @broadinstitute @insitubiology (Chen Lab) @HSCRB . Ex: @SangerInstitute @Cambridge_Uni @UniofOxford. He/him IG: @ajcrscience

 Cambridge, MA
andyrussell.github.io/
Joined July 2009
  • Tweets724
  • Following1.1K
  • Followers861
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Andy Russell retweeted
Dawn Chen
@dawnchenx2 Feb 2024
We are happy to share our latest long-range, programmable mutagenesis toolbox - the Helicase-Assisted Continous Editing (HACE) system - to achieve target-specific mutagenesis of the endogenous genome. (1/11) biorxiv.org/content/10.1101/…

Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes

A major challenge in human genomics is to decipher the context specific relationship of sequence to function. However, existing tools for locus specific hypermutation and evolution in the native...

biorxiv.org
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Andy Russell retweeted
Evan Macosko@macosko13 Dec 2023
Slide-tags unifies the single cell + spatial genomics worlds. It solves three key problems with existing spatial methods: 1) Cell segmentation (the biggest problem) 2) robustness and scalability (well-powered case-control studies now possible) 3) Multiomics (ATAC, RNA, etc)
Broad Institute@broadinstitute13 Dec 2023
A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of @insitubiology & @macosko. broad.io/slide-tags
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Andy Russell retweeted
Alex Cagan@ATJCagan9 Feb 2023
Andrew Russell on Slide-Tags: single-nucleus high-resolution multi-modal spatial genomics #AGBT23
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Andy Russell retweeted
Cell@CellCellPress5 Dec 2022
We are pleased to bring you the @CellCellPress paper of #FacesOfCell Irving Barrera (@Irving_Barrera1), “Dissecting the treatment-naive ecosystem of human melanoma brain metastasis” cell.com/cell/fulltext/S0092…
As a future LGBTQ and Hispanic physician, my goal is to bridge my scientific interests with the needs of underserved and marginalized populations, specifically in the field of mental health and substance abuse disorders.

ALT As a future LGBTQ and Hispanic physician, my goal is to bridge my scientific interests with the needs of underserved and marginalized populations, specifically in the field of mental health and substance abuse disorders.

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Andy Russell retweeted
Sophia Liu@immunoliugy11 Oct 2022
Presenting Slide-TCR-seq: our method for measuring the transcriptomes of cells & T cell receptor (TCR) sequences in situ! This collaboration w/ Bryan Iorgulescu, Shuqiang Li, Catherine Wu, and @insitubiology led to some cool findings... cell.com/immunity/fulltext/S… 1/8
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Sharing Photoselective Sequencing (PSS), a new method for genomic and epigenomic measurements within spatial regions of interest. Thanks to the whole team @haiqi_chen, @H3K4me1, @juliedobkin_, @DLesman, @JD_Buenrostro, and Fei Chen. biorxiv.org/content/10.1101/… (1/9).

Photoselective sequencing: microscopically-guided genomic measurements with subcellular resolution

In biological systems, spatial organization is interconnected with genome function and regulation. However, methods that couple high-throughput genomic and epigenomic profiling with spatial informa...

biorxiv.org
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we are recruiting multiple positions for my lab's glioblastoma work w @WellcomeLeap and our spatial genomics work at @sangerinstitute - please see below and share!
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Our new method, C-SIDE, for cell type-specific DE in spatial tx: biorxiv.org/content/10.1101/… Detects DE in diverse contexts such as space, disease, cellular interactions. Controls for cell type effects and mixing. Led by Dylan Cable and colab w/ @rafalab @macosko @Vignesh_Shan
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Andy Russell retweeted
Haiqi Chen@haiqi_chen20 Dec 2021
Excited to launch the Reproductive Genomics Laboratory @UTSWNews. Grateful for the support from folks @insitubiology & collaborators. We are recruiting at all levels - pls see website for details. RT appreciated! haiqichenlab.github.io/

The Haiqi Chen Lab @ UTSW

Website for the Haiqi Chen Lab at the Cecil H. and Ida Green Center for Reproductive Biology Sciences, UTSW

haiqichenlab.github.io
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Andy Russell retweeted
Josh Welch@LabWelch15 Dec 2021
We extended the RNA velocity model to incorporate epigenome data from single-cell multi-omic protocols like 10X Multiome. Key results: more accurate velocity estimation than RNA alone; inference of RNA/epigenome decoupling; and quantification of time lags. biorxiv.org/content/10.1101/…

Single-cell multi-omic velocity infers dynamic and decoupled gene regulation

Single-cell multi-omic datasets, in which multiple molecular modalities are profiled within the same cell, provide a unique opportunity to discover the relationships between cellular epigenomic and...

biorxiv.org
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Andy Russell retweeted
zack chiang
@z_chiang15 Dec 2021
Just released @Nature: slide-DNA-seq, our new method for spatial DNA sequencing in tissues 🧬 Excited to add a genetic dimension to the rapidly expanding spatial toolbox with the tech dev superteam of Tongtong Zhao, @JD_Buenrostro & @insitubiology (1/6) nature.com/articles/s41586-0…
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Thanks to @KafsackLab for this great spotlight on our latest addition to the #MalariaCellAtlas! Soon to be rounded out with some gametocyte 🌙 work coming from myself, @AndyRusss and @SunilDogga
Trends in Parasitology@TrendsParasitol12 Aug 2021
In this new Spotlight, Drs @C_Noetzel & @KafsackLab @WeillCornell highlight the recent @NatureComms article on #SingleCell #transcriptomics of #Plasmodium #falciparum from @drjakebaum @marakat @imperialcollege @sangerinstitute Free access at authors.elsevier.com/a/1dZNP…
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And it is out! It was a great pleasure to collaborate with @theosanderson @AndyRusss @amtalman @billker_lab @marakat @Waters_Group and others on this story. If you are interested in the Plasmodium sex determination - check out the preprint! biorxiv.org/content/10.1101/…

Regulators of male and female sexual development critical for transmission of a malaria parasite

The transmission of malaria parasites from vertebrate host to mosquito vector requires a developmental switch in asexually dividing blood-stage parasites to sexual reproduction. In Plasmodium berghei...

biorxiv.org
Theo Sanderson
@theosanderson11 Aug 2021
Expression of a single gene, AP2-G, is enough to make malaria parasites divert from reproducing asexually in our blood to become sexual forms ready to be eaten by a 🦟. But how do these genetically identical cells become ♂️ or ♀️? We tried to find out. 🧵 biorxiv.org/content/10.1101/…
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Emoji similarity map by @erindataviz. The map places emojis that are used together in tweets frequently close together. Great idea for a dataviz! Source: buff.ly/3Bc3QwI
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Andy Russell retweeted
Ferran Muiños@fmuinos28 Jul 2021
I am thrilled to announce that our work on In silico saturation mutagenesis of cancer genes is finally out @Nature. We propose a method inspired in evo biology to identify driver mutations in cancer genes. Here’s #tweetorial to sketch our results rdcu.be/cqsM1
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Hi everyone. I think you should all read @stephenkb's beautifully written thoughts on last night's game - and then sign up to his morning call e-mail if you haven't already - newstatesman.com/morningcall
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Congratulations to @AndyRusss for winning a Cambridge Society for the Application of Research PhD student award! 🎉 Find out more about Andrew’s work and award here ➡️ csar.org.uk/student-awards/2… #MalariaCellAtlas #PhDLife
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Join our young (!) and growing team @mims_umea, we are interested in developing new genetic tools to better understand malaria host- parasite interactions. Contact me for informal enquiries. Two postdoc positions available (1/2). – at Umeå, Sverige
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Recruiting two postdocs and a research assistant to use genetics/cell biology to understand malaria parasite erythrocyte invasion. Looking for enthusiastic talented folks to join our diverse collaborative team @TheCIMR Please apply, or mail for more info! bit.ly/2ZfNOAQ
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Andy Russell retweeted
Priyamvada Gopal ©@PriyamvadaGopal14 Aug 2020
Given our far too slow track record on "widening participation", as a matter of principle, @Cambridge_Uni should honour all existing offers made to state sector candidates regardless of result.
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