Perplexed sceptic & genetic epidemiologist @mrc_ieu @MRC_BSU @BristolUniPsych. Tutor @LSHTM & @StEdmundsCam.
Joined November 2017
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Benji Woolf retweeted
New publication "What phases of the drug development framework can epidemiological studies emulate?" at Am J Epi led by me (!), with contributions from @ja_labrecque_, @BarWoolf, Emily, David R, and Sofia: academic.oup.com/aje/advance…
Benji Woolf retweeted
New pre-print "Mendelian randomization in a multi-ancestry world: reflections and practical advice" led by @amymariemason - arxiv.org/abs/2510.17554
Benji Woolf retweeted
Really important work (and delighted to help) using pulmonary hypertension as a disease exemplar. Applicable across all rare disease I expect.
Benji Woolf retweeted
New manuscript led by @BarWoolf "A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension" is now published at Euro Respiratory Journal @ERSpublications: pubmed.ncbi.nlm.nih.gov/4096…. Summary follows:
Benji Woolf retweeted
New pre-print online: "Context-stratified Mendelian randomization: exploiting regional exposure variation to explore causal effect heterogeneity and non-linearity", arxiv.org/abs/2507.11088. We propose an alternative approach to assess non-linearity in Mendelian randomization.
Benji Woolf retweeted
Forgot to add the link to the manuscript: academic.oup.com/ajeadvances….
Benji Woolf retweeted
New paper published at AJE Advances: "The role of estimation in Mendelian randomization: should Mendelian randomization investigations provide estimates?" led by @BarWoolf and myself. Brief thread:
Benji Woolf retweeted
🚨 New preprint awaiting feedback! 🚨 led by the lovely and talented @martaalcalde18 looking at the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada) medrxiv.org/content/10.1101/…
Benji Woolf retweeted
New Mendelian Randomization from @LoukasZagkos @htcronje @BarWoolf @stevesphd @Yuan_AS @LarssonSC @jotzou @dpsg108 et al.: Long-term increases in circulating #caffeine may reduce bodyweight and the risk of osteoarthrosis and osteoarthritis. shorturl.at/blySV
Benji Woolf retweeted
**Flash Talks Event** Benjamin Woolf @BarWoolf shares his research "Comparison of caffeine consumption behavior with plasma caffeine levels as exposure measures in drug-target Mendelian randomization studies" Vote for your favourite talk: meg-uk.org/flash-talks-2024
Benji Woolf retweeted
New paper: "A frequentist test of proportional colocalization after selecting relevant genetic variants": arxiv.org/abs/2402.12171 led by Ash Patel. We introduce a new test for colocalization in a frequentist paradigm. Thread follows!
Benji Woolf retweeted
New study supports the potential for PDE5 inhibition to increase the number of children fathered by male patients, but finds no evidence of such an effect in female patients @BarWoolf #ChristmasBMJ
bmj.com/content/383/bmj-2023…
Benji Woolf retweeted
Thanks to Benji (@BarWoolf) and Dipender (@dpsg108) for leading this work, and for Skanda, Toinét (@htcronje), James (@jamesyrmsk), and the BMJ editors for their willingness to engage with both the science and the humour of the article. /END
Benji Woolf retweeted
Do biological mechanisms leading to penis stiffening make men happy? Do they make them more fertile? Find out in our new drug target Mendelian randomization article, led by @BarWoolf and now out at @bmj_latest: bmj.com/content/383/bmj-2023…
Benji Woolf retweeted
Excellent talk. Thanks for sharing.
One of the nice things about RCTs is that you only have to adjust for confounding in what you observe, so there is no residual confounding. (Although non-compliance causes a regression dilution.)
Observational studies are much trickier.
Brilliant seminar by Richard Peto @HarvardChanSPH about the influence of residual confounding in observational epidemiological studies. Compelling actual and hypothetical examples immediately suggest sensitivity analyses explicitly for this should be /cont youtube.com/watch?v=B0ZpenVs…
Benji Woolf retweeted
Out now in AJC ⬇️
Raising important questions about possible ancestry-specific CV disease aetiologies in East Asian and European populations.
Many thanks to the amazing international collaboration
@Ravinay @UAllahwala @dpsg108 @BarWoolf @ DanielHan
authors.elsevier.com/sd/arti…
Benji Woolf retweeted
This is my guy @BarWoolf doing some clever stuff to show how mis-specifying the exposure in drug target MR can cause all kinds of problems! Really nicely supervised by @stevesphd to have created a lovely paper
"Comparison of caffeine consumption behavior with plasma caffeine levels as exposures in drug-target Mendelian randomization and implications for interpreting effects on obesity" new preprint with @toinetcronje @LoukasZagkos @LarssonSC @dpsg108 @stevesphd medrxiv.org/cgi/content/shor…
Benji Woolf retweeted
Research by Bristol, @imperialcollege and @karolinskainst suggests genetic differences in how people metabolise #Caffeine may influence #Weight and risk of developing Type 2 #Diabetes☕️
Find out more @newscientist.
@BarWoolf @BristolTARG @BristolUniPsych
bit.ly/3JMla1U
Benji Woolf retweeted
Incorporating discovery and replication GWAS into summary data Mendelian randomization studies: A review of current methods and a ... biorxiv.org/cgi/content/shor… #biorxiv_genetic