@BaranelloL

Laura Baranello's group investigating topoisomerases, chromatin biology and cancer at @karolinskainst 🇸🇪🇮🇹🇦🇺🇷🇺🇩🇪🇺🇸🇬🇷

 Stockholm, Sweden
ki.se/en/cmb/laura-baranellos-group
Joined April 2019
  • Tweets158
  • Following373
  • Followers377
21Media
Welcome to the official Twitter account of Laura Baranello's group at @karolinskainst. Brace yourselves for some top quality scientific content! – at Stockholm, Sweden
2
1
13
Baranello Lab retweeted
Valerie Lamour@valeroche11 Apr 2024
Happy to share our latest work on DNA topology regulation ! With cryo-EM and magnetic tweezers, we unveil how DNA gyrase captures a DNA crossover in supercoiled minicircles. doi.org/10.1126/science.adl5… @Inserm @CNRS @IBENS_ENS @univ_paris_cite @bcmhouston @BCMFromtheLabs @IGBMC
1
19
2
51
5,169
Thank you @karolinskainst communications for highlighting this fantastic news!🧬🧬 news.ki.se/ki-researcher-lau…

KI-researcher Laura Baranello awarded ERC Consolidator Grant

KI researcher Laura Baranello has been awarded the prestigious ERC Consolidator Grant for her researches into the interaction between the cancer-driving protein MYC and topoisomerase enzymes. Her aim...

news.ki.se
1
16
695
Baranello Lab retweeted
Eugene Kim@eugene_kim__9 Mar 2024
Check out the beautiful coverpage of our paper @MolecularCell 😊
Jeppsson_lab@Jeppsson_lab8 Mar 2024
Excited to see our @MolecularCell cover illustrating dimers of Smc5/6 recognizing transcription-induced positive supercoiling! Made by Camilla Björkegren.
1
5
15
2,799
Thank you @ERC_Research for the chance to study the mechanism of topoisomerase-MYC regulation with an ERC consolidator grant! erc.europa.eu/news-events/ne…
12
1
46
3,245
ERC-funded postdoc position in chromatin biology of immune cells! Do you want to work in a collaborative and competitive environment with cutting-edge technologies? If you are interested, please apply below 👇 ki.varbi.com/se/what:job/job…

Postdoctoral Researcher in Chromatin Biology of Immune Cells (scholarship)

Do you want to contribute to improving human health? We are looking for an ambitious postdoctoral candidate that will contribute to advancing our understanding of how the oncoprotein MYC controls lymp

ki.varbi.com
3
9
1,247
Baranello Lab retweeted
Fena Ochs@OchsFena8 Mar 2024
Our new paper is out today in @ScienceMagazine showing that sister chromatid cohesion is mediated by individual cohesin complexes. Read about it here: science.org/doi/10.1126/scie… (1/4)

Sister chromatid cohesion is mediated by individual cohesin complexes

The sister chromatid cohesion necessary for faithful cell division is mediated by individual cohesin rings.

science.org
17
53
3
199
69,766
A few more people got happy in 2023-welcome to new LS1 @ERC_research grantees: #ERCStG Drago Milovanovic @DZNE_de, @KSomyajit, @berteroale, @janirbolla // #ERCCoG @BaranelloL Gerbrand van der Heden van Noort @LUMC_Leiden #ERCAdG @Geyer_lab @ThanbichlerLab erc.europa.eu/news-events/ne…
4
15
1,372
Proud to share our latests work in @ScienceAdvances on how coinhibition of Topoisomerase 1 and BRD4 induces tumor regression by targeting promoter pause release. Great team work #StephanHahn @ruhrunibochum! @karolinskainst @KAWstiftelsen @Vetenskapsradet science.org/doi/full/10.1126…

Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer...

TOP1 and BRD4 drugs synergize to kill pancreatic cancer in vivo via readthrough transcription without emergent drug resistance.

science.org
4
5
2
48
3,868
more replies
Due to alterations observed in replication timing via Repli-seq, we propose that transcriptional readthrough opens up the chromatin, allowing for activation of dormant replication origins (4/5).
1
2
167
However, this causes replication and transcription machineries to collide which is exacerbated in cancerous cells due to increased rates of both processes. This explains the cancer specificity of our treatment (5/5).
2
149
TOP1 is a common target in cancer therapy, and we aimed to enhance treatment efficacy for highly transcriptionally active cancers by additionally targeting TOP1 regulation via BRD4, a member of the BET family (1/5).
3
264
Baranello Lab retweeted
Davide Mazza@shiner8030 Dec 2022
Proud to share our latest preprint: we explore how chromatin organization and transcription factor search are related using a freshly built 🔬, to combine single molecule tracking of nuclear factors with structured illumination imaging of DNA. biorxiv.org/content/10.1101/…

Chromatin organization drives the exploration strategy of nuclear factors

Nuclear Factors (NFs) rapidly scan the genome for their targets, but the role of nuclear organization in such search is unexplored. To address this, we combined live-cell single-molecule tracking of...

biorxiv.org
3
21
8
157
52,111
It is great to meet again at EMBO topo meeting meetings.embo.org/event/23-d… #embodnatopology #emboevents #Airc #UNIBO
2
10
817
Extremely honoured to receive the 2023 J&J WiSTEM2D Scholars Award for the Science Category for our work on the mechanism of action of #topoisomerases jnj.com/wistem2d-university-… Congratulations to all the fellow awardees! @JNJNews @karolinskainst 🧬

WiSTEM2D Scholars

jnj.com
3
26
1,168
.@lilithnersisyan @sushuch @pelechanolab at KI and @scilifelab report in @NatureMicrobiol that their method can detect whether or not #bacteria respond to #antibiotics within minutes. Spinoff company @3NBio will take it from bench to bedside to fight #AMR. news.ki.se/new-method-reveal…
2
12
3
65
12,973
Replying to @karolinskainst @Nature @MPIbp
Link to publication ⬇️ nature.com/articles/s41586-0…
1
8
1,374
KI professor @GoCasteloBranco and colleagues @Yale report in @Nature that they have developed a #SpatialOmics technology that can map simultaneously how #genes are switched on/off and how they are expressed in different areas of tissues and organs. #RNA news.ki.se/new-technology-ma…
2
25
1
130
16,778
Extremely honoured to receive the BlueSkyGrant2022! Thanks to @CancerResKI for supporting our work on discovering new biomarkers for #topoisomerase-based therapy. Looking forward to exciting discoveries! @karolinskainst 🧬🧬ki.se/en/cancerresearchki/bl…

Blue Sky Research Grant Recipients

The Blue Sky Research Grant for Innovative Cancer Research is a one-year grant, providing SEK 500 000, to support an innovative pilot project aimed at demonstrating proof of principle. The project...

ki.se
2
23
1,319
Load more