Purdue University's IDEAS Lab built an autonomous drone that tracks runners through dense forests completely without GPS or cloud networks. By running 3D LiDAR mapping and obstacle-avoidance AI entirely on-chip, it can weave under tree canopies and predict target movement through blind spots in real time. Massive implications for next-gen search & rescue and edge AI.

Pretty much. As of the past few weeks, debt markets have almost entirely shut off access to money for any company that doesn’t have substantial revenue independent of AI data centers. SpaceX closed $40B of debt for GPUs, but we’re investment grade and have Starlink & launch revenue. That means the 200+ neoclouds are going to see guppy-level death and consolidation. Some will make it through, but not many.

this unironically destroys AI bots

There’s a really pronounced divide between people who are on the AI side of things and people who are on the biology side of things. Even among people working in AI, the divide persists based on where they’re focused. The AI side, adherents of scaling laws and the bitter lesson, believe that AI getting better means AI being more capable of novel discoveries in medicine (that go beyond discovering new drugs in well understood targets or speeding up dry lab work etc). The biology people think the idea of a bitter lesson in biology is kind of ridiculous and that regardless of AI’s capabilities it’s going to be at least 5-10 years until you could hope to reliably simulate human toxicology in silico (right now AI/ML can’t even reliably simulate in vivo studies like binding affinities or functional assays). Even the most AI pilled of them, who will list all the areas that AI can reduce the time spent on various areas, don’t think the concept of AI discovering novel targets or generating new understanding of causal biology is realistic in the near term. Most, in fact, will readily characterize the assumption that even an “ASI” level model could find cures hidden in our current understanding (without expanding that understanding with significantly more biological data) as patently false. This was a big part of why we wanted to experience it ourselves by using AI for a (very) small portion of what it can do in biology. It was both mind blowing and revealed some poignant insights into how different the problem of making AI better at something like coding is to the problems of biology. Even if it unlocked the ability to generate new molecules at a stunning pace, its simulation (in silico) of binding only had 49% accuracy. And if we wanted to improve that, we’d need to feed it back the data from the lab - data that took about 30x as long to get as it took to generate the molecules. And these were tests in a test tube (turn of phrase), imagine how long it would take if we wanted to improve the model with data that required recruiting humans and monitoring their reactions. Human biology is very complex, and adding a drug - especially a novel drug and doubly so for a novel drug acting on a novel mechanism - means mapping interactions that have nth-order-effects that we don’t have the data to predict. Virtual cells have made advancements enabled by AI, but the perturbations equate to a small fraction of the possible. This is before you even get into curing disease, especially uniquely human diseases. Brain function involves cellular identities that are unique to humans, meaning animal studies are of little use. How long does it take to understand what the side effects of chronic administration of a drug in humans are? AI can speed up analyzing the data, or designing the trial or even getting it approved…but it can’t make a 6 month trial complete in 3 months. I think its important to point out that significant advancements can be made in AI that contribute to biology, while also being realistic about how much it speeds up something as complex as curing a specific cancer or diseases of the brain.

The best ‘cheap’ life upgrade is a good pillow and it’s not even close.

Showing off expensive things might actually make people less interested in being your friend.

I’ve left Anthropic after more than a year of working on Claude Code and seeing it scale larger than I ever imagined. I have really loved working at Ant and believe deeply in the mission, and most of all, the idea of a race to the top. The idea that if we work hard and responsibly, we can raise the bar and inspire others to great outcomes. And if we all push each other to be better, things can be radically good. I will carry the spirit of this with me forever. My colleagues at Anthropic are the most talented, thoughtful, competent, and earnest people I have ever met. I am glad they are at the wheel and trust them deeply. To the community on X, thank you for everything. You’ve made this the most fun (and sometimes stressful) job I’ve ever had. For me, it is time for a bit of a break before diving into something new. If you want more excellent Claude Code content, you should follow @addyosmani , @lydiahallie, @_catwu, @ClaudeDevs and of course @bcherny who started it all.

I’ve left Anthropic after more than a year of working on Claude Code and seeing it scale larger than I ever imagined. I have really loved working at Ant and believe deeply in the mission, and most of all, the idea of a race to the top. The idea that if we work hard and responsibly, we can raise the bar and inspire others to great outcomes. And if we all push each other to be better, things can be radically good. I will carry the spirit of this with me forever. My colleagues at Anthropic are the most talented, thoughtful, competent, and earnest people I have ever met. I am glad they are at the wheel and trust them deeply. To the community on X, thank you for everything. You’ve made this the most fun (and sometimes stressful) job I’ve ever had. For me, it is time for a bit of a break before diving into something new. If you want more excellent Claude Code content, you should follow @addyosmani , @lydiahallie, @_catwu, @ClaudeDevs and of course @bcherny who started it all.

just finished my multiplayer system in C and turns out we can support 50k players in a single server at 60hz simulation tick of course not much happening on this demo but pretty sure we could support Fortnite level gameplay at 10k players.

If you want to ask someone a question, do not lead with “can I ask you a question?” You’re more likely to get a response if you actually ask a question rather than ask to ask a question.