First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

Fresh out of the oven, our collaboration with the Kopito Lab - UFL1(E3) modifies, binds to, and dissociates the 60S subunit from the Sec61 translocon! #ribosome #cryoEM

🎉We are thrilled to share our exciting new collaboration with @inada_lab and @jingdongcheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM

Check our most recent work in collaboration with the amazing @inada_lab. The study unveils the molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. #ribosome #cryoEM #MolecularCell Here's a thread with the most exciting findings🧵...

What does a human collided disome look like? In collaboration with the Inada lab, we show that mammalian disomes form a distinct structural interface, in which uS10 K63-linked polyubiquitination is critical for ribosome dissociation. ⬇️⬇️⬇️

Pull the ripcord to clear the traffic jam: RQT splits collided #ribosomes by engaging the emerging mRNA. Check out our new story at #bioRxiv: biorxiv.org/content/10.1101/…

Universal collisions!💥 Bacterial ribosome emergency ➡️ collision ➡️ disomes formation ➡️ recognition by SmrB ➡️ mRNA cleavage ➡️ ribosome rescue 🚑 Read the latest version of this story @Nature: nature.com/articles/s41586-0… Congrats to all people involved @GreenLabJHMI & A. Buskirk

Take the flag down: check our new preprint on removing the ubiquitin from the 40S ribosomal subunit by Otu2🚩 Great collaboration with the Inada lab! #cryoEM #ribosome biorxiv.org/content/10.1101/…

The proper description of translational arrest mechanism of TnaC (hidden before in PNAS 2018), now with RF2 and rescue factor ArfA as surprise (presumably result of SmrB cleavage). Online now @NAR_Open. Thanks to the von Heijne lab @Stockholm_Uni for a great collaboration! 1/2

Making the cut ✂️ Ribosomal collisions matter also in bacteria! Collided disomes recruit SmrB, which comes to the rescue by cleaving the mRNA. Happy collaboration with the amazing @GreenLabJHMI and Allen Buskirk! Preprint is out on @biorxivpreprint now! biorxiv.org/content/10.1101/…

Have a look at the distinct assembly pathway of the human late 39S pre-mitoribosome, now with E-site tRNA🧐 @biorxivpreprint @jingdongcheng biorxiv.org/content/10.1101/… Excited to see similar results from the Rorbach lab and @BMartinHallberg lab @karolinskainst

The real processome ➡️ ribosome biogenesis super-complex of 90S and RNA exosome @MolecularCell. Connected via helicase Mtr4, the exosome is positioned at the base of 5′-ETS helices H9-H9’ ✂️ Great work by @jingdongcheng and the Hurt lab @UniHeidelberg 🎉 cell.com/molecular-cell/full…

#CryoEM structure of the post‐translational Sec #translocon with substrate bound and X-ray/HDX of the Sec62 subunit. ➡️ @embojournal paper online now! Congrats to @tw_weng, @jingdongcheng, @BangeBalcony and everyone involved! 🎉👏 embopress.org/doi/abs/10.152…