Gut microbiota research; ETH Zürich
Zürich, Switzerland
Joined January 2018
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Proud to share our protocol for cultivating human #GutMicrobiota ex vivo! Special thanks to Janina Zünd for her key contribution! We've streamlined the cultivation process for maximum flexibility and throughput while ensuring high reproducibility (1/3) academic.oup.com/ismecommun/…
We provide a tolerance profile of gut microbes to oxidative stress and reveal previously overlooked sensitive taxa: L. eligens and F. saccharivorans doi.org/10.1093/femsec/fiaf0…
Interestingly, we previously showed that L. eligens is an important contributor to gut ILA. Taken together, this could explain the reduction of IPA in diseases associated with gut inflammation
doi.org/10.1080/19490976.202…
Benoit Pugin retweeted
🚨Just published in @NatureAging!
🧬 We discovered that a gut #microbiota-derived metabolite, phenylacetic acid (PAA), accumulates with age and triggers endothelial #senescence, a key driver of cardiovascular #aging.
#Saeedi_Lab
➡️ Read more nature.com/articles/s43587-0…
We identified new gut bacteria producing ILA and IPA: Lachnospira eligens and Enterocloster aldenensis. 🙌
We also highlight the importance of cross-feeding and dietary fibers.
Huge thanks Janina and to co-authors
#gut #microbiome #fibers #prebiotics
doi.org/10.1080/19490976.202…
Benoit Pugin retweeted
Out of the oven! Galacto-oligosaccharides alone and combined with lactoferrin impact the Kenyan #infantgutmicrobiota and epithelial barrier integrity during iron supplementation in vitro
oaepublish.com/articles/mrr.…
#Gutmicrobiome #micronutrient #prebiotic
Welcome to read and share!
Benoit Pugin retweeted
Our work describing the structure and mechanism of the Zorya anti-phage defense system is finally out @Nature! Led by @HaidaiHu and @__jphilipp in a wonderful collaboration with @NMITaylorLab, @SimonJacksonNZ, @AHarms485 et al.!
nature.com/articles/s41586-0…
Benoit Pugin retweeted
Did you know that your gut bacteria produce melatonin? #Melatonin is not only important for your sleep but for almost every organ in your body. Read more nature.com/articles/s41522-0…
Thank you @KurthSalome, Benoît Pugin and Nicholas Bokulich for your collaboration.
Benoit Pugin retweeted
10 days left to apply and join the lab 🔥 Great team spirit 💫 clavel.ukaachen.de @UniklinikAachen. Personalised syncoms of cultured gut bacteria in gnotobiotic mice 👇 nature.com/naturecareers/job…
Benoit Pugin retweeted
🚨Job alert🚨 We are recruiting a postdoc to develop and apply in vivo single-cell CRISPR screening methods. This builds upon our recent AAV-Perturb-seq work (nature.com/articles/s41586-0…).
Come join us in Basel, Switzerland! More info at: jobs.ethz.ch/job/view/JOPG_e…
Benoit Pugin retweeted
The lab is recruiting (postdoc level) 👇 Join us: we love good science and there is a great team spirit 💫 clavel.ukaachen.de; ukaachen.de/stellenangebote/…
Benoit Pugin retweeted
Latest Publication🥳
A pilot case-control study on the #fecalmicrobiota of #pediatric functional abdominal pain-not otherwise specified and the role of early life stress
View: 👇oaepublish.com/articles/mrr.…
#fecalmetabolites #earlylife stress
Welcome to read and share🤗
Benoit Pugin retweeted
A study on early life traumatic stress in mice suggest that changes in the fecal microbial community induced by early life stress can be perpetuated from an exposed parent to the offspring across two generations.
@BenoitPugin @IsabelleMMansuy
nature.com/articles/s42003-0…
Benoit Pugin retweeted
Join the online APC forum next Tuesday to listen to @BenoitPugin 🦠🩺 It will be followed by a Q&A session for early career scientists 🥼 @Pharmabiotic
Benoit Pugin retweeted
2 weeks left to apply! Are you a budding immunologist who likes to work across disciplines 🧬🧫🔬🧪? We would love to hear from you.
@Dunn_School
slacklab.etz.ch
Opening for a postdoctoral researcher at the Slack lab in Oxford!
Come and join our team to work on sampling of gut antigens for IgA priming.
my.corehr.com/pls/uoxrecruit…
slacklab.ethz.ch
Our protocol has become crucial in many of our #gut #microbiota research projects, uncovering donor-specific microbial activities and responses to various conditions, stimuli, or perturbations (2/3) #PersonalizedMedicine #Medicine #PersonalizedNutrition #Nutrition
Thanks to @ISMEComms reviewers, post-preprint release, we've tested our standardized medium (bYCFA with 6C+Muc; optimized to maximize the similarity of ex vivo cultures with the donor microbiota) against other media frequently used in ex vivo systems (BHI and GMM media) (3/3)
New paper out ! 🥳 We identified and characterized new intestinal bacteria producing tryptamine, and evaluated its effect on the rest of the gut microbial community frontiersin.org/articles/10.…
Benoit Pugin retweeted
🚨Job alert🚨 We are recruiting a PhD student for a project focused on the development of in vivo gene editing and functional genomics methods for applications in dissecting brain development and function. Come join us in Basel, Switzerland! More info at: jobs.ethz.ch/job/view/JOPG_e…
