Research Assistant Professor at School of Public Health HKU | Former member of UF infectious disease dynamics group
Joined May 2019
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Our new Fluscape work is out @eLife. We reported long term intrinsic cycles in individual antibody responses against 21 A(H3N2) strains that were isolated between 1968 and 2014. doi.org/10.7554/eLife.81457
Bingyi Yang retweeted
【Latest Research】A recent study led by Dr @BingyiY, Research Assistant Professor of #HKUSPH has analysed 200,000 hemagglutination inhibition (HAI) titrations from ferret models. This research reveals critical insights about influenza immune evasion. 🦠💡
🔍 Key Findings:
✔️ Breath of Influenza A viruses cross-reactivity varies by the isolation interval
✔ A(H3N2) has a narrower cross-reactivity compared to A(H1N1)
✔ Repeated exposures to the virus further broaden the cross-reactivity to contemporary viruses
This study provides a framework for predicting immune evasion in other rapidly evolving pathogens, making a major step for pandemic preparedness.
📄Paper now published in Nature Microbiology: rdcu.be/eqjg1
📹Featured on This Week in Virology (TWiV): bit.ly/45ZEt3l
@bencowling88
#HKU #HKUMed #HKUSPH #HKUPublicHealth #PublicHealth #Research #evolution #influenzavirus #Vaccineprotection #antibody
Bingyi Yang retweeted
【Latest Research】A team led by @BingyiY, Research Assistant Professor of #HKUSPH has revealed that neutralizing antibodies (nAbs) serve as a key immune correlate for COVID-19 vaccine protection.
🔍 Key Findings:
✔️ Neutralizing antibody (nAbs) levels and vaccine efficacy / effectiveness (VE) against mild Omicron infections decline significantly after >180 days
✔️ VE against severe or fatal COVID-19 stays >75% even when nAbs hit assay limits
✔️ Detectable nAb titers are not always sensitive enough to fully predict protection against severe disease and death from SARS-CoV-2
This study provides critical insights for long-term immunity understanding, booster strategies, and future vaccine development.
📄Paper now published in Nature Communications: bit.ly/4dMZCPR
@TimkTsang @bencowling88
#HKU #HKUMed #HKUSPH #HKUPublicHealth #PublicHealth #Research #vaccine #COVID19 #VaccineResearch #NeutralizingAntibodies
Bingyi Yang retweeted
Age and fever symptoms can help identify highly contagious influenza patients. Our research at #HKUSPH helps control and prevent flu transmission. Check it out👉🌍Original source:
orientaldaily.on.cc/content/…
Bingyi Yang retweeted
"The majority of immune protection against #SARSCoV2 conferred by natural infection cannot be fully explained by serum nAbs [neutralizing antibodies] alone." Varies considerably by variant
nature.com/articles/s41591-0…
@SunKaiyuan @NatureMedicine
Our recent study reassessed the lift of universal masks mandate suggested no evidence that such lift reduced SARS-CoV-2 transmission in schools. However, we revealed a significant difference when using incidence or transmissibility as outcome measurement. academic.oup.com/pnasnexus/a…
This is a reassessment of previously published study published in NEJM nejm.org/doi/full/10.1056/NE…
We replicated their positive association between lift the mandate and incidence, but we found no association when replacing the incidence to reproduction number.
We argued that incidence-based measures may not capture transmission fully, as they overlook exponential case changes and consequently violating the parallel assumption in DID analysis. Similar view and findings from other study: medrxiv.org/content/10.1101/…
Bingyi Yang retweeted
Our paper on the role of antigenic space in determining dengue disease risk is out as a cover article @ScienceTM
science.org/doi/10.1126/scit…
Bingyi Yang retweeted
New preprint: Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course
medrxiv.org/content/10.1101/…
1/12
Bingyi Yang retweeted
Fantastic opening to our 3-day international conference this morning #immunity2023 with many excellent presentations including opening talks by Malik Peiris and Maria Van Kerkove
Bingyi Yang retweeted
A short 🧵on a recent study by @MaggieLind2 with @MHitchingsEpi @datcummings Albert Ko et al. Data show that immunity induced by vaccines, prior infection or both (hybrid) protects against SARS-CoV-2 infection when viral exposure is low to moderate (1/)
nature.com/articles/s41467-0…
Bingyi Yang retweeted
How should we interpret recent patterns of SARS-CoV-2 evolution, from EG.5 to the new BA.2 descendent? What can we learn from other viruses? And where might things being heading next? I discuss some of the key ideas and research: kucharski.substack.com/p/wha…
Bingyi Yang retweeted
our Cobovax study observed similar incidences of omicron BA.2 infection across diff vaccination groups despite weak neutralising antibodies to BA.2 in 3rd-dose CoronaVac recipients, suggesting nAbs may not be appropriate correlates of protection for inactivated COVID-19 vaccines
New research article>
Comparative antibody and cell-mediated immune responses, reactogenicity, and efficacy of homologous and heterologous boosting with CoronaVac and BNT162b2 (Cobovax): an open-label, randomised trial
thelancet.com/journals/lanmi…
#COVID19
ALT Background Few trials have compared homologous and heterologous third doses of COVID-19 vaccination with inactivated vaccines and mRNA vaccines. The aim of this study was to assess immune responses, safety, and efficacy against SARS-CoV-2 infection following homologous or heterologous third-dose COVID-19 vaccination with either one dose of CoronaVac (Sinovac Biotech; inactivated vaccine) or BNT162b2 (Fosun Pharma–BioNTech; mRNA vaccine). … Interpretation Similar levels of incidence of, presumably, omicron BA.2 infections were observed in each group despite very weak antibody responses to BA.2 in the recipients of a CoronaVac third dose. Further research is warranted to identify appropriate correlates of protection for inactivated COVID-19 vaccines.
Bingyi Yang retweeted
A #HKUSPH research observes high mortality during the Omicron BA.2 wave in Hong Kong due to lower vaccine coverage (42%) among adults ≥65 years old.
⬆ in antiviral usage & vaccination uptake over time in 2022 was associated with ⬇ case fatality risks.
medrxiv.org/content/10.1101/…
Bingyi Yang retweeted
A #HKUSPH & @UChicago research on childhood immune imprinting studied data in Hong Kong and finds:
▪those imprinted to H1N1/H2N2 ➡17% lower risk of getting H1N1
▪if imprinted to H3N2 ➡12% lower risk
@TimkTsang @sarahcobey @bencowling88
@JIDJournal:bit.ly/3Xvml9M
Bingyi Yang retweeted
It isn't simply #stimulate, stimulate, stimulate,... prior #immunity dictates #infection #risk, but also quality of the #antibody #response, #antigenic #breadth of how much you can be #boosted
Our new Fluscape work is out @eLife. We reported long term intrinsic cycles in individual antibody responses against 21 A(H3N2) strains that were isolated between 1968 and 2014. doi.org/10.7554/eLife.81457
Lastly, the phase of titers residuals to the circulating strains are correlated with seroconversions, after accounting for pre-existing titers to these strains. Higher risks of seroconversion when the individual titers were more away from the population average (e.g, phase IV).
