@Brain_VTA

BrainVTA is an international AAV packaging supplier, aim to provide cost-effective, high-quality viral solutions for basic research and clinical trial.

brainvta.tech/
Joined July 2022
  • Tweets1.7K
  • Following4.4K
  • Followers1.4K
149Media
🔥Lots of Pre-made AAVs @Brain_VTA Check out catalog: brainvta.tech/plus/list.php?… 📌Shipping from Maryland or China, delivered in 3-7 days! 🔥AAV-HBV/Pseudo- LV/VSV-coronavirus 🔥Customized large-scale AAV/LV/Ad packaging Email: [email protected] #gene #mechanism #neurosciences
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❗️❗️❗️Honored to be cited in Science Advances 👏👏👏Prof. Lei Cao’ team discovers that an imbalance in mitochondrial homeostasis, mediated by MFN2 in astrocytes, drives depression-like behaviors. @Brain_VTA offers AAV packaging services. science.org/doi/10.1126/scia…

MFN2-associated astrocyte dysfunction contributes to neuronal hyperexcitability and depressive-like...

Astrocyte pathology is increasingly recognized as a key factor in the pathogenesis of major depressive disorder (MDD), where disrupted glutamate clearance and impaired neuron-glia interactions...

science.org
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❗️❗️❗️Honored to be cited in Nature Communications 👏👏Prof. Baolin Guo/Shengxi Wu’ team reveals a novel mechanism by which a neuronal-astrocytic iron-regulatory signaling axis mediates the development of anxiety. @Brain_VTA offers AAV packaging services. nature.com/articles/s41467-0…

Anterior cingulate input tunes striatal dynamics for context-dependent social preference in a mouse...

Nature Communications - The mechanisms underlying social behavioural deficits in mouse models of autism are not fully understood. Here the authors link neural embedding geometry to...

nature.com
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❗️❗️Honored to be cited in STTT 👏👏Prof. Zhuo Wang’ team reveals a novel mechanism by which a neuronal-astrocytic iron-regulatory signaling axis mediates the development of anxiety. @Brain_VTA offers AAV packaging services. science.org/doi/10.1126/scia… nature.com/articles/s41392-0…

Vitamin D binding protein in ventral CA3 of the hippocampus drives stress-induced depression

The ventral hippocampus plays a crucial role in regulating emotional and motivated behaviors. However, the molecular mechanisms underlying its dysfunction in major depressive disorder (MDD) remain...

science.org
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❗️❗️❗️News︱Neuron 👏👏👏Why does sleep help us remember things better? Prof. Min Xu’s team has uncovered a new mechanism by which M2-type acetylcholine receptor-positive neurons in the hippocampus regulate memory consolidation. 👇MORE cell.com/neuron/abstract/S08…

An acetylcholine-inhibited sleep-active hippocampal interneuron orchestrates memory consolidation

Sleep is crucial for long-term memory formation. Feng et al. now show that a unique population of hippocampal interneurons is preferentially active during NREM sleep and plays a critical role in...

cell.com
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❗️❗️❗️News︱Neuron 👏👏👏Why does sleep help us remember things better? Prof. Min Xu’s team has uncovered a new mechanism by which M2-type acetylcholine receptor-positive neurons in the hippocampus regulate memory consolidation. 👇MORE doi.org/10.1016/j.neuron.202…
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❗️❗️❗️News︱Nature Aging 👏👏👏Can age-related memory impairment be improved without relying on increased neurogenesis? Prof. Nannan Guo’s team reveals a new mechanism involving PLA2G7 derived from neural stem cells. 👇MORE nature.com/articles/s43587-0…

Suppressing neural stem cell PLA2G7 restores inhibitory circuit function and improves cognition in...

Nature Aging - Wu, Wu and colleagues identify PLA2G7, a secreted lipid-metabolizing enzyme, as a negative regulator of inhibitory synapses in the dentate gyrus. Suppression of PLA2G7 in neural stem...

nature.com
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❗️❗️Honored to be cited in Science Advances 👏A New Strategy for Diagnosis and Treatment! Prof. Zhijun Zhang’ team Discovers That Vitamin D-Binding Protein in the Ventral Hippocampus Drives Depression-Like Changes. @Brain_VTA offers AAV packaging services. science.org/doi/10.1126/scia…

Vitamin D binding protein in ventral CA3 of the hippocampus drives stress-induced depression

The ventral hippocampus plays a crucial role in regulating emotional and motivated behaviors. However, the molecular mechanisms underlying its dysfunction in major depressive disorder (MDD) remain...

science.org
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❗️❗️❗️Honored to be cited in Advanced Science 👏👏👏Prof. Lei Sun’ team Achieves Precise Regulation of Neural Circuits in Deep Brain Regions: Development of a Sonogenetic Strategy Driven by Targeted Nanotechnology. @Brain_VTA offers AAV packaging services. advanced.onlinelibrary.wiley…

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

This study introduces mechanogenetics, a nanobubble-enhanced sonogenetic strategy for selective modulation of feeding-related neural circuits in the mouse lateral hypothalamus. Mechanogenetic...

advanced.onlinelibrary.wiley.com
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❗️❗️❗️News︱Neuron 👏👏👏Prof. Shuming An’s team reveals the neural mechanisms by which neuronal clusters in the zona incerta mediate restorative sleep to alleviate pain through distinct neural circuits. 👇MORE cell.com/neuron/abstract/S08…

Recovery sleep induces analgesia via sleep ensembles of the zona incerta acting through distinct...

Haiyan Sun and Liu et al. identify sleep-activated zona incerta neuronal ensembles mediating NREM sleep and analgesia. Chronic pain suppresses these neurons, whereas their activation promotes NREM...

cell.com
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❗️❗️❗️News︱Neuron 👏👏👏Major Breakthrough! How Does the Brain Control Backward Movement? Prof. Minmin Luo’s team Identifies a Center for Backward Locomotion, Uncovering a Brainstem Motor Circuit for Directional Selection. 👇MORE cell.com/neuron/abstract/S08…

A brainstem module for backward locomotion reveals direction-selective premotor circuits

Liu et al. identify a brainstem module that drives backward locomotion and show that distinct premotor circuits control forward movement, turning, locomotor arrest, and backward movement. The...

cell.com
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Our paper is out in Nature, congrats to Qiyu, An et al! By stimulating ~20 motor cortex neurons carefully selected based on their activity, we could induce learned population activity and, sometimes, the movement itself, depending on the brain's state. nature.com/articles/s41586-0…

Targeted stimulation of motor cortex ensembles drives learned movements

Nature - Optogenetic stimulation of motor-cortex neuron ensembles shows that precisely timed activity in the primary motor cortex can generate learned neural patterns and movements, demonstrating...

nature.com
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Mapping neural circuits？ @BrainVTA now offers CTB retrograde tracers across 4 fluorescence channels 🟢CTB-488—bright, low background 🟠CTB-555—great contrast in multi-color panels 🔴CTB-594—avoids tissue autofluorescence 🔵CTB-647—deep penetration, ideal for confocal&multiphoton
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👏New Technology! Prof. Minmin Luo’s team Develops a Cross-Species Microglial AAV Platform, Enabling Highly Efficient and Specific Genetic Manipulation. 4 key innovations: 🧬MSRE 🦠AAV2/9.m 🎯miR-9 detargeting ⚙️Microglia-tailored codon optimization 👇MORE cell.com/neuron/abstract/S08…

A cross-species AAV platform for precise microglial interrogation

Yu et al. develop an AAV system for efficient, selective microglial transduction across mice, rats, macaques, and ex vivo human cortical slices. The platform enables structural labeling, calcium...

cell.com
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❗️❗️❗️News︱Neuron 👏👏👏Prof. Weiguang Li’s team reveals the staged neural circuit mechanisms underlying reduced motivation in chronic pain.. 👇MORE cell.com/neuron/abstract/S08…

Stepwise engagement of cingulate ensembles underlies motivational decline in chronic pain

Xu, Sun, et al. show that neuropathic pain engages anterior cingulate outputs in stages in male mice. Amygdala-projecting neurons contribute to early mechanical hypersensitivity, whereas habenula-p...

cell.com
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❗️❗️❗️Honored to be cited in CNS Neuroscience & Therapeutics 👏👏👏Prof. Zhen Wang’ team elucidates the mechanism by which Compound Acanthopanax Senticosus Granules alleviate anxiety and depression. @Brain_VTA offers AAV packaging services. onlinelibrary.wiley.com/doi/…

Compound Ciwujia Granules Attenuate Stress‐Induced Anxiety‐ and Depression‐Like Behaviors via...

By restoring glutamatergic neuronal activity, suppressing TNF-related inflammatory signaling pathway, and reducing microglial overactivation in the dmPFC, CWJ ameliorated stress-induced behavioral...

onlinelibrary.wiley.com
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❗️Honored to be cited in Neuron 👏Back-to-Back | New Advances in Neural Circuits! Prof. Wei Shen’ team Reveal a Novel Mechanism by Which the Prefrontal Cortex–Zona Incerta–Reward System Regulates Compulsive Eating. @Brain_VTA offers AAV packaging services. cell.com/neuron/fulltext/S08…

Anterior zona incerta to ventral tegmental area circuit controls compulsive eating in a binge-eat...

Chen et al. identify anterior zona incerta aZIT neurons as key drivers of compulsive binge eating. Intermittent high-fat-diet exposure increases GABAergic aZIT neuronal excitability, thus enhancing...

cell.com
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❗️❗️❗️News︱Experimental & Molecular Medicine 👏👏👏Prof. Hua Yuan’s team reveals the key mechanisms by which rTMS alleviates motor dysfunction and neuropathic pain following spinal cord injury. 👇MORE nature.com/articles/s12276-0…

Drp1 in M1 layer V GABAergic neurons orchestrates rTMS-mediated motor restoration and analgesia...

Experimental & Molecular Medicine - Spinal cord injury (SCI) leads to severe motor deficits and neuropathic pain, significantly impacting quality of life. This study explores the potential of...

nature.com
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❗️❗️❗️Honored to be cited in Neuron 👏👏👏Why Does Motivation Gradually Decline? Prof. Weiguang Li’ team Reveals the Phasic Circuit Mechanisms Underlying Impaired Effort Persistence in Chronic Pain. @Brain_VTA offers AAV packaging services. cell.com/neuron/abstract/S08…

Stepwise engagement of cingulate ensembles underlies motivational decline in chronic pain

Xu, Sun, et al. show that neuropathic pain engages anterior cingulate outputs in stages in male mice. Amygdala-projecting neurons contribute to early mechanical hypersensitivity, whereas habenula-p...

cell.com
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❗️❗️❗️News︱Science Advances 👏👏👏Prof. Liangyi Chen’s team reveals MIMAS, extending the observational scale of brain dynamics during free behavior from single synapses to the trans-cortical level. 👇MORE science.org/doi/10.1126/scia…

MIMAS: An open-source microlens-array miniature microscope for accessible large-field cortical...

Large-scale cortical dynamics during natural behavior are difficult to measure because head-mounted imaging systems must balance field of view, spatial resolution, weight, and optical complexity....

science.org
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❗️❗️❗️News︱Advanced Science 👏👏👏Prof. Xiang Cao’s team reveals a novel mechanism by which the cytoskeletal protein β-adducin maintains lysosomal homeostasis and protects ischemic neurons. 👇MORE advanced.onlinelibrary.wiley…

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in...

This study identifies β-adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia-associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β-adducin...

advanced.onlinelibrary.wiley.com
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