Dirk Brenner's research group in Luxembourg @LIH_Luxembourg and @uni_lu. We study #immunology, #immunometabolism in inflammation and cancer.
Luxembourg
Joined May 2018
- Tweets484
- Following243
- Followers977
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Brenner Lab retweeted
Excited to share our new work uncovering a previously unknown mechanism identifying ANKIB1 as the E3 ligase that writes a critical new letter of the ubiquitin code central for immune signalling: K11-linked ubiquitin nature.com/articles/s41556-0…
Brenner Lab retweeted
Check out the comments of Professors Dirk Brenner @Brenner_Lab and Bart Everts @EvertsBart on this paper "Blocking lactate: kick T cells when they are down" journals.lww.com/immunometab… Welcome to read!
I've been on a Twitter moratorium for the last week given the.. news, but I'm happy to announce a new story from our group @NatImmunol describing a metabolic sensitivity of exhausted T cells to lactic acid in tumors! 1/ nature.com/articles/s41590-0…
Brenner Lab retweeted
2 weeks left to register for #Mito25 in the Dominican Republic. Amazing program and speaker lineup 🌴🔬🧪☀️
@DavidFinlayTCD we are looking forward to your presentation at #Mito25 this coming February☀️There is only 2 WEEKS left to register, so please RT to let your followers know limited spaces remain to join us in the Dominican Republic! 🇩🇴
Register here➡️bit.ly/3zPBufN
Brenner Lab retweeted
Check out our latest work, hot off the press @MolecularCell
Novel Selenium Carrier Protein Regulates Ferroptosis in Cancer and Brain🧫
👉Read more: t1p.de/kr969
Scientists at #HelmholtzMunich have uncovered the selenium carrier protein PRDX6 as a critical player in #ferroptosis - a cell death process that holds promise for #cancer and neurodegenerative disease #therapies.
💡This study reveals PRDX6’s dual role as both a regulator of #OxidativeStress and a selenium transporter, essential for maintaining cellular defenses against damage.
🌟Implications: Targeting PRDX6 may increase sensitivity to ferroptosis in cancer cells, a potential new strategy against therapy-resistant #tumors. In neurodegenerative diseases like #Alzheimer’s, PRDX6 could help protect neurons by supporting selenoprotein production, opening doors for therapeutic advancements.
@Conrad_Lab @Ferroptosis2306 @Ferroptosis1
#CancerResearch #NeurodegenerativeDisease #Selenium #MultipleSclerosis
ALT Novel Selenium Carrier Protein Regulates Ferroptosis in Cancer and Brain
Brenner Lab retweeted
Our lab is looking for a postdoc with interest and experience in mucosal immunology and gut microbiome: nature.com/naturecareers/job…
Brenner Lab retweeted
Supported by @ImmunoMetEurope, @ImmunoMetNet, @BSI_immunomet, @ImmunoMet @immunemet, @SocietyEuropean and others working on immunometabolism, the aim of the Immunometabolism journal @Immunometaboli2 is to further grow and to become THE go-to journal in this exciting field
Our journal welcomes short commentary articles to put recently published high-impact work in a broader perspective. 🥳🥳🥳Interests in writing a commentary, contact our EiC Professor Jan Van den Bossche
@immunometlab and the EB member Professor Sarah Dimeloe @SarahDimeloeLab
Brenner Lab retweeted
Check out Professor David K. Finlay
@DavidFinlayTCD from Trinity College Dublin et al's comments on this paper. journals.lww.com/immunometab…
We made it on the cover of @Cell_Metabolism! Incredible artwork & research by Lynn Bonetti @LIH_Luxembourg, our lab & collaborators. ROS, glutathione, mitochondria, ETC, Th17 cells, infections & gut health! Check it out @FnrLux @uni_lu @science_lu @ImmunoMet @ImmunoMetEurope
Brenner Lab retweeted
A fantastic day celebrating the 40th anniversary of the discovery of the TCR. Check out this T cell speaker photo which includes co-discoverers Tak Mak and Mark Davis. Thanks @UofT, @uoftmedicine, @ImmunologyUofT, @thePMCF for your support.
Brenner Lab retweeted
Super excited to share my PhD work, out now in @Nature. Here, myself, @lynchielydia, and all my wonderful co-authors explored the link between circadian rhythms, energy homeostasis and innate T cell function.
A thread: 🧵
nature.com/articles/s41586-0…
Brenner Lab retweeted
Ready for #DC2024Barcelona?
We have ahead of us 4 fascinating days to share new data & discussions and to boost basic & translational research on #dendriticcells
25 top🌍speakers, 46 short talks, 200 posters, >300 attendees! support by @SEinmunologia @SCImmunologia @EuMacDcSoc
Brenner Lab retweeted
And after listening caspases discoverer Prof. Junying Yuan and former colleague Wei Xie talks, we say goodbye to Luxemburg with new ideas and contacts to be made!!!! Thanks
@Brenner_Lab
for such a great conference!!! #ECDO24
Brenner Lab retweeted
We all know our body temps change in fever & inflammation, but we rarely model it the lab (just setting incubators to 37..). There is much more to it! Congrats to @DarrenHeintzman for this epic effort & new T cell stress response with STING & p53.
science.org/doi/10.1126/scii…
Brenner Lab retweeted
Our latest paper "NaCl enhances CD8+ T cell effector functions in cancer immunotherapy" is now out @NatImmunol nature.com/articles/s41590-0… 🥳🎉🍾. A 🧵:
Brenner Lab retweeted
FDA approves IDH1 and IDH2 inhibitor for brain cancer nature.com/articles/d41573-0…
this is indeed a milestone that many of us have assisted almost in real time from that original science paper in 2008 (Parsons et al). Remarkable!
Brenner Lab retweeted
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation dlvr.it/TBlKsk
Brenner Lab retweeted
🙏RT #dendriticcell lovers
🚨#DC2024Barcelona 🚨 in numbers:
25 🌍top invited speakers
46 selected speakers for short talks
>200 posters
📆REGISTER NOW: EARLY REGISTRATION DEADLINE 31st July!!!!
dc2024barcelona.com/index.ph…
Brenner Lab retweeted
We are pleased to announce the ECDO2024 Honorary Award to Prof. Marcus Conrad for his pioneering work in the field of ferroptosis. Do not miss his lecture at ECDO2024 in Luxembourg, where ferroptosis and its future therapeutic applications will be one of the major hot topics!
Brenner Lab retweeted
Beyond short-chain fatty acids: Non-SCFA microbial metabolites associated with fiber fermentation and host health
Check out our new review cell.com/trends/endocrinolog… in @Trends_Endo_Met
Brenner Lab retweeted
With a massive response to abstract submissions, ECDO 2024 in Luxembourg is already close to overbooking.
Register now and don't miss your chance to join us, ECDO 2024 is going to be a blast
Register at: express.converia.de/frontend…
#ECDO2024 #Conference #Luxembourg