Studying cellular signalling and proteostasis in response to mitochondrial dysfunction.
Helsinki, Finland
Joined June 2019
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🔥This opens a path toward targeting v-ATPase with precision, with implications from cancer to mitochondrial disease.
Mild v-ATPase inhibition boosts ΔΨm and restores cell fitness under mitochondrial mistranslation stress — even in patient-derived fibroblasts.
🔬A major effort led by Geoffray, revealing how cells deploy extra-organellar control to survive mitochondrial dysfunction.
🚨 New from our lab (est. 2020) — now published in Nature Communications!
🧬We uncover a surprising link between the v-ATPaseand mitochondrial function:
Mild v-ATPase inhibition restores cell fitness under mitochondrial mistranslation stress
nature.com/articles/s41467-0…
(Thread ⬇️)
JacksonLab retweeted
Together with @mito_oncogene, today we report in Nature Genetics a peculiar + exciting discovery: positive selection of mutations to mitochondrial ribosomal RNA in cancer. Led by Sonia Boscenco, Jacqueline Tait-Mulder, and Minsoo Kim nature.com/articles/s41588-0…
JacksonLab retweeted
Local de novo synthesis of serine delays mitochondrial muscle disease progression. Tour de force work of Christopher Jackson and @marmyleva_ana Anastasiia Marmyleva. Congrats Anastasiia especially for your first 1st author paper! @ASW_lab cell.com/cell-reports/fullte…
JacksonLab retweeted
✨Excited to share our new paper in @CellReports! ✨We show how cells rely on self-made serine to protect themselves under mitochondrial stress. Huge thanks to my mentors @CBJacksonLab and @AWartiovaara 🙏
cell.com/cell-reports/fullte…