The ISARIC Coronovirus Clinical Characterisation Consortium is recruiting COVID-19 patients. Urgent public health research supported by @NIHRresearch @HPRUezi
Joined February 2020
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Recruitment to @CCPUKstudy stops today. We hibernate now and prepare for the next exposure of Public Health Interest. Our Outbreak Data Analysis Platform is open for research with over 303k cases of #COVID19 isaric4c.net/sample_access/ @kennethbaillie @p_openshaw @ProfCalumSemple
ISARIC4C retweeted
“I am thrilled to have this opportunity to work for the people and government of Scotland, providing evidence and scientific advice to support our policymakers. @ScotSciChief gov.scot/news/championing-th…
ISARIC4C retweeted
🚨 New paper!
Working with colleagues from @CVRinfo, @UKHSA, @KingsCollegeLon & @CCPUKstudy, we investigated the emergence of tecovirimat resistance during severe mpox infection in a patient with advanced HIV. 🦠 💊 🧬
👉sciencedirect.com/science/ar…
ISARIC4C retweeted
Timely collation, linkage and analysis of data has been key to informing the public health and clinical response in outbreaks of MERS, COVID-19, and Childhood Acute Severe Hepatitis of Unknown Origin @CCPUKstudy @ISARIC1 #DataSavesLives
I have laid out how sharing data improves direct patient care, NHS effectiveness and supports medical research gov.uk/government/speeches/u…
The Information Commissioner, National Data Guardian and I have explained the benefits of clinical staff sharing data to support patient care.
I have laid out how sharing data improves direct patient care, NHS effectiveness and supports medical research gov.uk/government/speeches/u…
The Information Commissioner, National Data Guardian and I have explained the benefits of clinical staff sharing data to support patient care.
ISARIC4C retweeted
I have laid out how sharing data improves direct patient care, NHS effectiveness and supports medical research gov.uk/government/speeches/u…
The Information Commissioner, National Data Guardian and I have explained the benefits of clinical staff sharing data to support patient care.
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ISARIC4C retweeted
In general, the impact of Covid-19 on causing critical illness, i.e needing intensive care, in children lessened over the first two years of the pandemic, including when the omicron variant became dominant @CCPUKstudy @ISARIC1
Researchers from @livuni have contributed to a paediatric study that provides valuable insights into the impact of Covid-19 on hospitalised children during the pandemic.
Read more here news.liverpool.ac.uk/2023/09…
@ProfCalumSemple
ALT An illustration of a doctor using a stethoscope on a child sitting on a mother's knee. Text overlaid reads: "These findings highlight the importance of considering different paediatric age groups when assessing disease severity in Covid-19 and can help play a role in public health policies." Professor Calum Semple, Professor of Outbreak Medicine and Child Health
ISARIC4C retweeted
Yes, along with loss of biodiversity, changing habitats of animals, illegal wild life trade, urbanisation, trade and travel. All key drivers more frequent & complex epidemics & pandemics. The epidemic events are symptoms of our changing world & need to address the key drivers
ISARIC4C retweeted
TL;DR:
Our preprint was 1ST to report association btwn #AAV2 & hepatitis cases, found on metagenomic sequencing in 9/9 early 🏴cases vs 0/58 controls. #adenovirus found in 6/9 cases.
Cases also >likely to carry HLA DRB1*04:01 allele (8/9; 89%) vs 🏴blood donors (16%) 2/
Doctors, scientists, & public health teams are working together, learning lessons from their responses to past outbreaks pandemics. This new way of working has led to the rapid discovery of the cause of this mystery disease @ISARIC1 @kennethbaillie @ProfCalumSemple
🌟Proud to share our paper 'Adeno-associated virus 2 infection in children with non-A-E hepatitis', out in @Nature today!🌟
nature.com/articles/s41586-0…
@CVRinfo @UofGlasgow @P_H_S_Official @RHCGlasgow @CCPUKstudy
A🧵highlighting key updates from preprint released in July 2022 1/
ISARIC4C retweeted
U.S. FDA Advisory Committee (VRBPAC) voted support the safety and effectiveness of GSK AREXVY™ (RSVPreF3 OA), 12-0 on effectiveness and 10-2 on safety.
precisionvaccinations.com/rs…
ISARIC4C retweeted
Cases (n=9):
- admitted 14 March-4 April 22
- recruited to @CCPUKstudy
- 4 male; median age 3.9 (IQR 3.4-5.1)
- most had GI symptoms 1-11 wks b4 hepatitis
- no immunocompromise
- none had covid 💉
- Hep A-E, EBV/CMV, HHV6/7, HSV, autoantibodies neg
- no transplants/ deaths
2/
ISARIC4C retweeted
@ISARIC1 @CCPUKstudy publication on our data platform. Thank you all partners & members for your contributions.
rdcu.be/cSWBU
ISARIC4C retweeted
Comment piece from David Ulaeto, Miles Carroll & me: Evolutionary implications of human transmission of monkeypox: the importance of sequencing multiple lesions thelancet.com/journals/lanmi…
We need multiple lesion samples & sequencing now to prove this @ISARIC1 @CCPUKstudy
ISARIC4C retweeted
Timely release of our latest @CCPUKstudy study, led by @LanceTurtle, evaluating impact of #immunocompromise (IC) on outcome in hospitalised #COVID19.
TL;DR: Despite effective 💉& Rx, IC individuals remain at ⬆️ risk of death from COVID19 compared to immunoconpetent persons. – at Glasgow, Scotland
Today there is a lot of coverage of immune compromised people and whether the antibody treatment #Evusheld would benefit this population. Of relevance to this, is our latest pre-print on COVID-19 in hospitalised immune compromised people.
@evusheld4theuk
medrxiv.org/cgi/content/shor…
ISARIC4C retweeted
🚨New preprint🚨
Adeno-associated virus 2 infection in children with non A-E #Hepatitis
A case-control investigation of 9 early cases in #Scotland & 58 controls.
@CVRinfo @P_H_S_Official @RHCGlasgow @CCPUKstudy @ucl @UKHSA @emcat1
🧵1/
medrxiv.org/content/10.1101/…
Great result and further evidence of the value of preparedness studies set up in readiness for future outbreaks of novel disease @gail_carson (the original CI), @ProfCalumSemple (CI & coLead) @kennethbaillie (coLead), @p_openshaw (coLead), @OutbreakJake & many more
🆕 Recent acute #hepatitis cases of unknown origin in children have now been linked to the virus AAV2, with no evidence of a direct link to #SARSCoV2 infection, in two new studies led by @UofGMVLS @GreatOrmondSt and @UCLchildhealth.
Find out more ➡️ bit.ly/3vcAzRc
ALT Centre For Virus Research
ISARIC4C retweeted
Brilliant News Jo and Team. Thank you so much for your help with @CCPUKstudy @ISARIC1
We won!!! So happy and so nice for all of us to be recognised for what we do during such a stressful time. Now let’s party!!! @LivuniILCaMS @livuniHLS @drchrisfrench
ISARIC4C retweeted
Many many congratulations to @ShonaCMoore, winning the Outstanding Contribution During The Covid-19 Pandemic, Shona and the team in our outbreak laboratories delivered the @CCPUKstudy which saved lives and enabled discovery on #COVID19
For UK hospitals that are ISARIC4C sites or are treating monkeypox patients and want to offer participation in the UK version of the CCP, see the updated UK CRF at isaric4c.net/protocols/
@CCPUKstudy
