@CMordstein

RNA Therapeutics | Gene expression regulation RNA by Design Leader @ Centillion | Views my own. ***Find me where the sky is blue ➡️ @cmordstein.bsky.social

 Cambridge, UK
Joined June 2018
  • Tweets2.6K
  • Following1.2K
  • Followers692
87Media
👉 Transcription, mRNA export and immune evasion shape the codon usage of viruses Happy to see another joint-effort from @KudlaLab & @Prof_LDHurst lab out now @GenomeBiolEvol bit.ly/3hv4hef We tried to address some fundamental questions re virus codon usage: (short🧵)
3
13
3
54
Looking forward to representing #Centillion at this fantastic event and discussing current and future trends in RNA therapeutics #RNAtx #RNArocks
magda maslon 🇺🇦 #StandWithUkraine@magdamaslon13 May 2025
Excited to be organizing an RNA Symposium Kraków! We've got a fantastic lineup of speakers from academia & industry @MCarmoFonseca J.Kjems Willeke van Roon @CieslaMaciej @TomaszWTurowski @JemielityLab @BhiveLaboratory @monika_piwecka A.Fiszer @molecure_sa @CMordstein @Centillion
1
5
347
Great to see this finally out. Congratulations @ikafetzo and everyone involved! 👇
Duncan Sproul@sproul_lab9 Jan 2025
New pre-print alert 🚨 Interested in what @ikafetzo learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: biorxiv.org/content/10.1101/… For a quick summary see this 🧵 1/8 #epigenetics

DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A

Loss of DNA methylation is a hallmark of cancer that is proposed to promote carcinogenesis through gene expression alterations, retrotransposon activation and induction of genomic instability....

biorxiv.org
1
3
405
Christine Mordstein retweeted
Sara Macias@SaraMaciasRNA18 Nov 2024
recruiting a PhD student to study the role of RNA binding proteins 🧬for viral defence 🦠during embryonic development🐁 👶. Funding routes for both UK and international students are available 🌻. Please send your CV and motivation letter if interested saramaciasribela.wixsite.com…
1
15
1
21
3,169
Christine Mordstein retweeted
Maxime Wery@wery_maxime19 Nov 2024
Thrilled and proud to see the "mRNA Decay: Methods & Protocols" book published. A great and enriching first editorial experience. Thanks to the wonderful #RNA colleagues who contributed to it. Please share ! link.springer.com/book/10.10…

mRNA Decay

link.springer.com
2
14
37
2,486
Christine Mordstein retweeted
Prof. Nikolai Slavov
@slavov_n8 Nov 2024
The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
11
237
2
1,058
126,298
Christine Mordstein retweeted
Christine Mordstein@CMordstein9 Nov 2024
@cmordstein.bsky.social 👀
1
113
👇 This 💯
Gal Haimovich ☣ 🔬🎗
@grnfluoresceblg10 Nov 2024
Hi Science friends and followers - its time to move to Bluesky. Over the past 2 weeks the number of my followers has doubled from ~200 to ~400 with alsmot all of them scientists. We have starter packs (designated lists of who to follow e.g. by research fields).
1
144
@cmordstein.bsky.social 👀
1
113
Christine Mordstein retweeted
Peter Stefanovic
@PeterStefanovi226 Oct 2024
This is a heartbreaking watch Since founded in 2020 @Frontline_19 has provided free counselling & psychological support to over a million NHS & frontline workers. The incredible work they do is vital & important. Please support them if you can🙏❤️
19
387
30
801
896,113
Christine Mordstein retweeted
Prof. Nikolai Slavov
@slavov_n2 Nov 2024
Remember RNA degradation. Exosomes are 3' --> 5' ribonucleases mediating maturation, quality control, and turnover of diverse RNAs in eukaryotic cells.
8
127
2
660
76,523
Christine Mordstein retweeted
🧬Jacob L Steenwyk
@jlsteenwyk1 Nov 2024
Agreed! That's why I wrote ggpubfigs, a ggplot2 extension that *only colorblind-friendly color palettes. Easily make your figures colorblind-friendly with ggpubfigs! xitter.cf/NKWhiteman/status/1852…
13
288
13
1,611
203,972
Christine Mordstein retweeted
Ewan Birney@ewanbirney31 Oct 2024
RNA biology is always so fiddly and complex, and increasingly I think alternative splicing is less about *protein* diversity and more about RNA transcript dynamics (eg, turnover, translation, cellular localisation)
15
55
6
415
45,584
Christine Mordstein retweeted
Sho Goh Lab@ShoGohLab30 Oct 2024
Achievement Unlocked! @huihuian521, our 1st PhD student’s 1st 1st-author paper! Out now in @MolecularCell 🧵 We identify the 1st m6Am Reader and uncover a novel and unexpected mechanistic role for this abundant yet enigmatic mRNA modification. (1) cell.com/molecular-cell/abst…
2
9
2
48
4,703
Optimizing Beer Glass Shapes to Minimize Heat Transfer arxiv.org/abs/2410.12043
91
Further evidence for strong non-neutrality of yeast synonymous mutations academic.oup.com/mbe/advance… @MolBioEvol

Further Evidence for Strong Nonneutrality of Yeast Synonymous Mutations

Abstract. Although synonymous mutations are commonly assumed neutral or nearly so, recent years have seen reports of fitness effects of synonymous mutation

academic.oup.com
1
1
4
529
Christine Mordstein retweeted
Ewan Birney@ewanbirney30 Oct 2024
New paper 📣 - "A comprehensive survey of RNA modifications in a human transcriptome" by @logan_mulroney, Lucia Coscujuela Tarrero and colleagues from an excellent collaboration between Francesco Nicassio's lab at @IITalk and my group @emblebi biorxiv.org/content/10.1101/…

A comprehensive survey of RNA modifications in a human transcriptome

RNA modifications are critical for transcript function and regulation. Direct RNA nanopore sequencing offers a unique advantage by observing these modifications through characteristic alterations in...

biorxiv.org
2
24
82
11,101
Christine Mordstein retweeted
Nucleobased@nucleobased30 Oct 2024
Interesting read: "Mechanistic insights into ASO-RNA complexation: Advancing antisense oligonucleotide design strategies" cell.com/molecular-therapy-f… #Oligonucleotides

Mechanistic insights into ASO-RNA complexation: Advancing antisense oligonucleotide design strate...

Hörberg and colleagues’ study emphasizes the importance of considering RNA 3D structure in ASO design. Through MD simulations, it reveals that RNA hairpin motifs and common triple bps significantly...

cell.com
3
19
1,241
Christine Mordstein retweeted
Duncan Sproul@sproul_lab25 Oct 2024
🚨New Review🚨 We've recently seen huge advances in our understanding of de novo DNA methyltransferase function. @WillowRolls and @mdrwilson and I have written a mini-review on what human disease mutations told us: doi.org/10.1042/BST20231017 #Epigenetics #Epigenomics 🧵 1/2

Using human disease mutations to understand de novo DNA methyltransferase function

DNA methylation is a repressive epigenetic mark that is pervasive in mammalian genomes. It is deposited by DNA methyltransferase enzymes (DNMTs) that are canonically classified as having de novo...

portlandpress.com
2
10
2
38
3,614
Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay embopress.org/doi/full/10.10…

Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and...

The EMBO Journal - Complete cytoplasmic polyadenosine tail (polyA-tail) deadenylation is thought to be essential for initiating mRNA decapping and subsequent degradation. To investigate this...

link.springer.com
1
174
Were you unable to watch a live webinar and want to catch up on what you missed? You can have access to all the past webinars on our website. Check out these past educational webinars at your convenience! oligotherapeutics.org/webina… #OTS #oligotherapeutics #oligonucleotides
2
3
389
Load more