COIOSCatalyst

Of temperature-attributable deaths in South Korea in 1990-2023, 30.1% were from avoidable causes, 15.3% preventable and 14.8% treatable. Circulatory diseases formed the largest avoidable share, linked to both cold and heat. coios.me/temperature-attribu…

Care management algorithms trained on past utilisation under-selected disadvantaged groups in a simulation on 201,216 US adults. Training on self-reported health status instead nearly closed the Black-White gap. coios.me/care-management-alg…

Dementia diagnoses rose sharply in the month after COVID-19 in 18.3 million adults in English GP records. The hazard ratio was 2.05 if vaccinated and 8.69 if not. Cognitive impairment after hospitalisation stayed raised for up to 4 years. coios.me/covid-19-and-later-…

Cervical cancer caused an estimated 887,000 new cases and 369,000 deaths worldwide in 2023, and both are forecast to rise by 2050. The figures are modelled estimates, not direct counts. coios.me/cervical-cancer-cas…

Stopping statins at 65 and over was linked to more hospitalisation in England, but not in severe frailty, dementia or care homes. At 1 year the sHR was 1.22 overall, falling from 1.30 in fit people to 1.03 in severe frailty. coios.me/statin-discontinuat…

Oropharyngeal cancer incidence across 29 European countries rose fastest in Ireland, the UK and Denmark, with 22,063 new cases in 2024. The HPV-attributable fraction ran from 20.2% in Slovenia to 71.7% in Sweden, taken from a literature review. coios.me/oropharyngeal-cance…

Of 76,200 new antidepressant users in Manitoba, 30.2% filled only once and 75.4% stopped within a year. Income assistance (OR 0.57) and tricyclics versus SSRIs (OR 0.31) predicted lower persistence. Switching to another antidepressant counted as stopping. coios.me/antidepressant-pers…

Of 39,975 UK drug-related deaths in coronial records, about one in 11 was rural. Intentional self-poisoning caused 17.3% of rural deaths against 9.5% of urban deaths, and rural deaths involved more prescribed drugs. coios.me/rural-drug-related-…

Polygenic risk for colorectal cancer in 405,453 UK Biobank participants gave hazard ratios, high against low, of 3.72 before age 55 and 2.01 from age 75. Excess risk from combining genetic risk with an unfavourable lifestyle appeared only from age 55. coios.me/colorectal-cancer-p…

The eighth MJA-Lancet Countdown report attributes 65% of heatwave days in Australia and 73% in New Zealand in 2021-2025 to climate change. It puts the cost of heat deaths at ages 65 and over in Australia at an estimated US$1.49 billion a year. coios.me/heatwave-exposure-o…

Three UK food tax designs, modelled on a synthetic UK population, cut daily intake by 25, 42 and 58 kcal. Lifetime NHS costs fell by £168 to £374 per person. Only the sugar and salt tax gave larger QALY gains in more deprived groups. (@TheLancetPH) coios.me/uk-food-tax-designs…

Cancer in first-generation migrants across six European registries: cervical, stomach and liver risk rose with birth-country incidence, while breast and colorectal risk was lower in every category. (@medrxivpreprint) coios.me/cancer-risk-in-firs…

Cancer screening and mental health disorders in Taiwan: people with severe disorders screened less for breast (aOR 0.81) and bowel cancer (aOR 0.88), though over 60% were top-quartile outpatient users. coios.me/mental-health-disor…

Colorectal cancer in the US: age-adjusted incidence fell from 55.2 per 100,000 in 2000 to 36.7 in 2022, then rose to 38.3 in 2023, in SEER registries covering 45.8% of the population. coios.me/colorectal-cancer-i…

GrimAge in 247 Dutch centenarians: each standard deviation of acceleration carried a mortality HR of 1.41, independent of cognition. Of five clocks, only GrimAge was associated with both chronological age and mortality. (@medrxivpreprint) coios.me/grimage-epigenetic-…

Dementia in North West London: emergency admission rates were 5.35 times those of residents without dementia before diagnosis and 6.67 times after. Records covered 1,260,798 residents aged 50 or older. (@medrxivpreprint) coios.me/dementia-and-emerge…

Living alone and mortality in 3,771 older Koreans: the all-cause hazard ratio of 1.49 fell to 0.95 and lost significance after weighting that added income, education and area. coios.me/living-alone-and-mo…

A polygenic score for smoking persistence in 139,129 current and former smokers in All of Us: the adjusted median quitting age was 48 in the highest decile and 40 in the lowest. (@medrxivpreprint) coios.me/smoking-persistence…

Weather and child hospitalisation in Sweden: among 4,638,247 children aged 6-18, all-cause admissions rose with mean temperature, peaking at hot extremes. Intraday temperature variability showed a U-shaped association. (@medrxivpreprint) coios.me/weather-and-child-h…