@CanAztekin

Group Leader @MPI_Bio and Friedrich Miescher Lab/Branco Weiss Fellow. Studying how to regrow limbs! Alum: @EPFL ELISIR / @Cambridge_Uni @GurdonInstitute

 Tübingen, Germany
fml.tuebingen.mpg.de/63796/aztekin-lab
Joined November 2018
  • Tweets816
  • Following708
  • Followers1.7K
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🚨Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @ScienceMagazine, we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 science.org/doi/10.1126/scie… #EvoDevo

Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration

Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus...

science.org
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Tugce Aktas@_taktas_Oct 6
I am thrilled to share our newest work in collaboration with Zack Smith’s lab. This is one of the 3 papers created by this fruitful partnership mainly driven by our star postdoc Yusuke Kijima. biorxiv.org/content/10.64898…

Epigenetic regulators partition the genome by evolutionary and developmental constraint

Many epigenetic regulators play essential roles in animal development, but precisely how they function across different cell types without clear sequence preferences remains a foundational challenge....

biorxiv.org
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Had such a blast throughout this symposium and event! And Team 2 wins the trivia!! 😂 🏆🧠
STEMCELL Technologies
@STEMCELLTechOct 1
We loved being part of the inaugural Early Career Stem Cell & Developmental Biology Symposium in Seattle! Catch our live @stemcellpodcast episode we recorded with Drs. Crystal Rogers and Ariel Waisman, coming Oct. 13. Thanks @AllenInstitute, @ISSCR, @SocDevBio, and everyone else!
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Meng Zhu@zhumeng123Sep 24
Two years since the 1st submission, our work on limb heterochrony is finally out! 🎉🎊@CellCellPress Delayed hindlimb dev vs forelimb is a widely conserved trait in mammals. We show that maternal O2 regulates this phenotype 👉🏻 shorturl.at/MGrwl

Shifts in embryonic oxygen levels cue heterochrony in limb initiation

Mammalian embryos see a substantial increase in available oxygen once the placenta forms. This increase in oxygen exposure serves as a trigger for initiating the development of the hindlimb, thus...

cell.com
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#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Our step-by-step protocol for generating mesodermal/limb bud organoids (“budoids”) from mouse stem cells or primary limb buds is now out! 🧫🦵 We hope it makes the system easier to adopt and build on in other labs! bio-protocol.org/en/bpdetail…
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And if you’re new to budoids, you can find the original study describing their development and applications here 👇 science.org/doi/10.1126/scia…

Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid...

Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.

science.org
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Fantastic news! 🎉 Huge congratulations to our postdoc @SilviaDaPra for being awarded an @EMBO Postdoctoral Fellowship! Exceptionally well deserved. We're so proud of you and excited to see what comes next 🐸 #FrogPower ! bio.mpg.de/541945/silvia-da-…

Silvia Da Pra erhält EMBO-Postdoktorandenstipendium

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Thrilled to receive the 2026 Schering Young Investigator Award! 🥳🤩 A huge thank you to all students, postdocs, collaborators, and mentors who have been part of this journey. Many thanks to the jury and the Schering Stiftung for this honor. bio.mpg.de/523934/can-azteki…

Can Aztekin erhält den Schering Young Investigator Award 2026  

bio.mpg.de
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Can Aztekin@CanAztekinApr 30
🔬 Diverse species. Stem cells. Highly international team. 🐸🐭 We’re looking for a Technical Assistant to join our stem cell–based research. Interested? Apply here 👉 jobs.tue.mpg.de/jobs/276
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Meng Zhu@zhumeng123Apr 30
Cambridge → Boston → Cambridge again: I’m thrilled to return to Cambridge(UK) to open my lab @GurdonInstitute @Cambridge_Uni !🥳 (mzhulab.com) We study how dev timing shapes and being shaped by plasticity, evolution & ageing. 🚩Hiring at all levels: pls email! 📩
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🔬 Diverse species. Stem cells. Highly international team. 🐸🐭 We’re looking for a Technical Assistant to join our stem cell–based research. Interested? Apply here 👉 jobs.tue.mpg.de/jobs/276
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Two new Science studies in mice explore the roots of vertebrate limb regeneration and show that manipulating tissue mechanics, oxygen levels, and epigenetic signals can unlock regenerative potential. The findings have the potential to open new doors for improved healing in humans. 📄: scim.ag/4cowHBk 📄: scim.ag/4dL7tQa
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Can Aztekin@CanAztekinApr 10
🚨Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @ScienceMagazine, we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 science.org/doi/10.1126/scie… #EvoDevo

Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration

Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus...

science.org
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EPFL@EPFL_enApr 13
Researchers at EPFL have discovered how oxygen-sensing explains why amphibians regenerate limbs and mammals do not. actu.epfl.ch/news/when-oxyge…

When oxygen determines if a limb can regrow

Researchers at EPFL have discovered how oxygen-sensing explains why amphibians regenerate limbs and mammals do not.

actu.epfl.ch
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EPFL@EPFLApr 13
Une équipe de l'EPFL a découvert comment la détection de l'oxygène explique pourquoi les amphibiens régénèrent leurs membres et pas les mammifères. actu.epfl.ch/news/quand-l-ox…

Quand l'oxygène détermine si un membre peut repousser

Une équipe de l'EPFL a découvert comment la détection de l'oxygène explique pourquoi les amphibiens régénèrent leurs membres et pas les mammifères.

actu.epfl.ch
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"La capacité de régénération n'est pas perdue chez les mammifères, elle est simplement inactive" 👉 l.sciencesetavenir.fr/KQg
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Scientific American
@sciamApr 9
Oxygen and hyaluronic acid may play a role in tissue recovery and regeneration, two new studies suggest spklr.io/6010EJTdC

Why can’t humans regenerate limbs? New research offers a clue

Oxygen and hyaluronic acid may play a role in tissue recovery and regeneration, two new studies suggest

scientificamerican.com
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This work started at @EPFL , @epflSV and submission/revision took place during our relocation and lab rebuild (!)at our new home @maxplanckpress @MPI_Bio Enormous thanks to both institutions for supporting the project throughout!!
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Massive team effort—especially @GeorgeTsissios many thanks to our collaborators @EpiGN_Lab , @WickstromLab , and others who contributed. Cheers!🍾🥂🥳
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