@CeMM_papers

A twitter bot account sharing all papers produced by CeMM - unofficial account

 Vienna, Austria
cemm.at
Joined March 2015
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Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy dlvr.it/T10cbK

Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1...

Ultimately, this multilayered serum analysis led to a potential marker signature with 10 key markers significantly altered in at least two independent serum cohorts: CRP, LYVE1, SAA2, C1RL, CFHR3,...

pubmed.ncbi.nlm.nih.gov
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GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway dlvr.it/T0yqnm

GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway - PubMed

Preserving cells in a functional, non-senescent state is a major goal for extending human healthspans. Model organisms reveal that longevity and senescence are genetically controlled, but how genes...

pubmed.ncbi.nlm.nih.gov
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The pathophysiology of sepsis and precision-medicine-based immunotherapy dlvr.it/T0yqmN

The pathophysiology of sepsis and precision-medicine-based immunotherapy - PubMed

Sepsis remains a major cause of morbidity and mortality in both low- and high-income countries. Antibiotic therapy and supportive care have significantly improved survival following sepsis in the...

pubmed.ncbi.nlm.nih.gov
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Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders dlvr.it/T0l2Gs

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resist...

Degraders hold the promise to efficiently inactivate previously intractable disease-relevant targets. Unlike traditional inhibitors, degraders act substoichiometrically and rely on the hijacked...

pubmed.ncbi.nlm.nih.gov
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Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity dlvr.it/T0X54m

Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflam...

In women living with obesity, abdominal SAT volume, especially sSAT, is associated with circulating leukocytes and inflammatory proteins. In men, these parameters mainly show associations with VAT...

pubmed.ncbi.nlm.nih.gov
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Cohesin and CTCF do not assemble TADs in Xenopus sperm and male pronuclei dlvr.it/T0SvfP

Cohesin and CTCF do not assemble TADs in Xenopus sperm and male pronuclei - PubMed

Paternal genomes are compacted during spermiogenesis and decompacted following fertilization. These processes are fundamental for inheritance but incompletely understood. We analyzed these processes...

pubmed.ncbi.nlm.nih.gov
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Effects of Tulp4 deficiency on murine embryonic development and adult phenotype dlvr.it/T0P68h

Effects of Tulp4 deficiency on murine embryonic development and adult phenotype - PubMed

Genetically engineered mouse models have the potential to unravel fundamental biological processes and provide mechanistic insights into the pathogenesis of human diseases. We have previously...

pubmed.ncbi.nlm.nih.gov
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Human Autosomal Recessive DNA Polymerase Delta 3 Deficiency Presenting as Omenn Syndrome dlvr.it/T0BvRc

Human Autosomal Recessive DNA Polymerase Delta 3 Deficiency Presenting as Omenn Syndrome - PubMed

The DNA polymerase δ complex (PolD), comprising catalytic subunit POLD1 and accessory subunits POLD2, POLD3, and POLD4, is essential for DNA synthesis and is central to genome integrity. We identif...

pubmed.ncbi.nlm.nih.gov
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Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling dlvr.it/T0BvQ9

Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling - PubMed

Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via the ubiquitin-proteasome system. While MGDs were historically discovered serendipitously, approaches for MGD...

pubmed.ncbi.nlm.nih.gov
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RIF1 regulates early replication timing in murine B cells dlvr.it/T02prn
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Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8 dlvr.it/Szy81w

Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine...

Creatine is an essential metabolite for the storage and rapid supply of energy in muscle and nerve cells. In humans, impaired metabolism, transport, and distribution of creatine throughout tissues...

pubmed.ncbi.nlm.nih.gov
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Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy dlvr.it/Szqx6X

Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair...

The therapeutic efficacy of cisplatin and oxaliplatin depends on the balance between the DNA damage induction and the DNA damage response of tumor cells. Based on clinical evidence, oxaliplatin is...

pubmed.ncbi.nlm.nih.gov
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An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis dlvr.it/Szqx3k

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis - PubMed

Myeloid cells are known to suppress antitumour immunity1. However, the molecular drivers of immunosuppressive myeloid cell states are not well defined. Here we used single-cell RNA sequencing of...

pubmed.ncbi.nlm.nih.gov
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Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche dlvr.it/SzfbxQ

Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche - PubMed

PDGFRA-expressing mesenchyme supports intestinal stem cells. Stomach epithelia have related niche dependencies, but their enabling mesenchymal cell populations are unknown, in part because previous...

pubmed.ncbi.nlm.nih.gov
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Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype dlvr.it/SzZy6T

Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype - PubMed

Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by...

pubmed.ncbi.nlm.nih.gov
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Using an embryo specific promoter to modify iron distribution pattern in Arabidopsis dlvr.it/SzWvS0

Using an embryo specific promoter to modify iron distribution pattern in Arabidopsis - PubMed

Iron is an essential micronutrient for life. During the development of the seed, iron accumulates during embryo maturation. In Arabidopsis thaliana, iron mainly accumulates in the vacuoles of only...

pubmed.ncbi.nlm.nih.gov
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Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma dlvr.it/SzWvMd

Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma...

The radiomic risk score was a robust and complementary predictor of survival and reflected characteristics in underlying DNA methylation patterns. Leveraging imaging phenotypes to assess risk and...

pubmed.ncbi.nlm.nih.gov
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Diverse macrophage populations contribute to distinct manifestations of human cutaneous graft-versus-host disease dlvr.it/SzP28m

Diverse macrophage populations contribute to distinct manifestations of human cutaneous graft-ver...

Overall, our data reveal a surprisingly dynamic role of MNPs after HSCT. Specific and time-resolved targeting to repolarize this cell subset may present a promising therapeutic strategy in combatting...

pubmed.ncbi.nlm.nih.gov
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2,4-Dichlorophenoxyacetic Acid Induces Degeneration of mDA Neurons In Vitro dlvr.it/SzJhFr

2,4-Dichlorophenoxyacetic Acid Induces Degeneration of mDA Neurons In Vitro - PubMed

Background: Parkinson's disease (PD) affects 1-2% of the population over the age of 60 and the majority of PD cases are sporadic, without any family history of the disease. Neuroinflammation driven...

pubmed.ncbi.nlm.nih.gov
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Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency dlvr.it/SyZYVz

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency - PubMed

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs)1,2, conferring a...

pubmed.ncbi.nlm.nih.gov
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