Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism @ImperialMDR @imperialcollege
Imperial College London
Joined October 2024
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Section of Cell Biology and Functional Genomics retweeted
We are excited to welcome Professor @WaljitD Dhillo as the new Head of the Department of Metabolism, Digestion and Reproduction.
Read this interview about his personal journey, his vision for the MDR and reflections on his 27 years @imperialcollege ⬇️
imperial.ac.uk/news/articles…
Job opening - Assistant Professor, Imperial Faculty of Medicine (20 Positions) - deadline 11/03/26:
rb.gy/r5d1k8
If you are an islet biologist—or cell biologist more broadly—working in diabetes and/or GPCR research, we would be delighted to host you in our Section!
Section of Cell Biology and Functional Genomics retweeted
Amazing 2 days discussing the latest research at the @Soc_Endo Endocrine Metabolic GPCRs 2026 Meeting. Fantastic speakers from different angles: cell biology, physiology, drug discovery, etc. Icing on the cake was our very own PhD student Linda Wong winning the Best Poster Award!
Great opportunity to join us at Imperial - 20 Assistant Professor positions at the Faculty of Medicine have just been advertised. See below:
imperial.ac.uk/jobs/search-j…
Section of Cell Biology and Functional Genomics retweeted
I am delighted to report that our latest paper has now been published in Science Advances:
science.org/doi/10.1126/scia…
In this study, we generated and characterised a humanised GLP‑1R mouse model carrying the gain‑of‑function A316T variant using CRISPR/Cas9 knock‑in technology.
Section of Cell Biology and Functional Genomics retweeted
Here is a link to an article about our study on the website of our funder @DUK_research: diabetes.org.uk/about-us/new…
Section of Cell Biology and Functional Genomics retweeted
Signaling Architecture of the Glucagon-Like Peptide-1 Receptor
In this contribution to JCI’s Review Series on Clinical Innovation and Scientific Progress in #GLP-1 Medicine, Gregory O Austin & Alejandra Tomas @TomasLab_ICL @imperialcollege explore the spatiotemporal regulation of #GLP-1R signaling: doi.org/10.1172/JCI194752
Section of Cell Biology and Functional Genomics retweeted
Our review is now out in JCI, where we discuss current evidence for the existence of GLP-1R–cAMP–PKA signalosomes at different subcellular locations, and the complexity of the GLP-1R spatiotemporal signaling architecture:
jci.org/articles/view/194752
Section of Cell Biology and Functional Genomics retweeted
Fantastic collaboration with Sarah Rouse's team now published in:
nature.com/articles/s42003-0…
Here we map lipid binding sites for all 15 human class B1 GPCRs, revealing conserved lipid interaction dynamics patterns, and further examine the effect of GM3 on GLP-1R vs GIPR ECD opening.
Section of Cell Biology and Functional Genomics retweeted
Research led by Imperial (@TomasLab_ICL) has uncovered a hidden cellular mechanism that explains how widely used type 2 diabetes drugs signal to protect the pancreas, opening up new possibilities for improving future diabetes therapies. ⬇️
imperial.ac.uk/news/articles…
Section of Cell Biology and Functional Genomics retweeted
I am extremely pleased to announce that our paper is now published in Nature Communications. Here, we show for the first time that the GLP-1R signals from endosomes by forming contacts with the ER via the ER membrane contact site tethers VAPA and VAPB🧵
nature.com/articles/s41467-0…
Section of Cell Biology and Functional Genomics retweeted
Science doesn’t need to go according to plan; it just needs to lead to a discovery. If doesn’t have to be done alone or together with a buddy; there just needs to be a discovery. It doesn’t need to happen fast or slow; just as long as there’s a discovery, then everybody is happy.
Our Section joined the Division of Diabetes, Endocrinology & Metabolism Networking Day on Tuesday 1st July - a day packed with Science, Career advice and other fun activities! @ImperialMDR
Section of Cell Biology and Functional Genomics retweeted
Congratulations to @LilianeEleid who successfully passed her PhD viva yesterday! Here are some pictures of the post-viva celebrations. Many thanks to Prof David Hodson @daveyboyhod and Dr Bryn Owen @BrynMOwen for assessing her thesis and to David for his visit and Seminar.
Are you interested in developing a research programme in cell biology of diabetes? Do you work in pancreatic islets and/or other metabolically relevant cell types? We have a Lectureship position opening to establish a lab in our Section at @imperialcollege (link to apply below)
Section of Cell Biology and Functional Genomics retweeted
Thrilled to now be a Fellow of the Higher Education Academy (FHEA)! Thanks to the Imperial College London STAR team and @AidaMartinezS and @TomasLab_ICL @CellBiolMDR
Section of Cell Biology and Functional Genomics retweeted
Our collaboration with the talented Sarah Rouse @ImperialLifeSci now out in bioRxiv:
"Human class B1 GPCR modulation by plasma membrane lipids"
biorxiv.org/content/10.1101/…
Section of Cell Biology and Functional Genomics retweeted
Our attempt to tag endogenous GIPR in vivo with a Halo-tag
biorxiv.org/content/10.1101/…
