@CellRepMethods

A new multi-disciplinary, gold #OA journal from @CellPressNews publishing cutting-edge methodological advances.

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Joined November 2020
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Standardizing spatial transcriptomic analysis for infectious diseases with STID dlvr.​it/TW1qcy
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mChIP-seq for multiplex epigenomic profiling uncovers cancer-specific histone features in cellular and circulating nucleosomes dlvr.​it/TW1lPl
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Apus enables automated end-to-end analysis and quality control of large-cohort proteomics data dlvr.​it/TVwyR8
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A dataset of differentiable biologically derived single-neuron models dlvr.​it/TVw9pm
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Acute in vivo proximity labeling for membrane-targeted proteomics in neuronal circuits dlvr.​it/TVtc9f
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Automated cross-session ROI tracking for multicellular calcium imaging with OPTIC dlvr.​it/TVpQgp
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Mycobacterium tuberculosis gene expression dynamics in host environments with single-cell resolution dlvr.​it/TVngyd
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High-throughput, amplification-free detection of endogenous gene expression perturbations via fluorescence anisotropy dlvr.​it/TVnbK8
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In vivo electrophysiology in head-fixed and freely moving mole-rats dlvr.​it/TVkljc
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stFormer integrates spatial ligand signaling into a foundation model for spatial transcriptomics dlvr.​it/TVjr33
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SurpHer: A genetically encoded ratiometric biosensor for dynamic extracellular pH imaging dlvr.it/TVj0J8

SurpHer: A genetically encoded ratiometric biosensor for dynamic extracellular pH imaging

Holste, Dos Santos, et al. develop SurpHer, a genetically encoded ratiometric biosensor for imaging extracellular pH at the surface of living cells. Through modular screening, they develop a membra...

cell.com
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Intravital 3-photon microscopy of leukocyte dynamics in the splenic white pulp dlvr.it/TVfHPL

Intravital 3-photon microscopy of leukocyte dynamics in the splenic white pulp

Schienstock et al. present a technical framework using surgical preparation of the mouse spleen, intravital 3-photon microscopy, and quantitative image analysis to interrogate in vivo leukocyte...

cell.com
227
A knockin Ntsr1Flp driver enables intersectional and systemic targeting of heterogeneous midbrain dopamine circuits dlvr.it/TVdYqV

A knockin Ntsr1Flp driver enables intersectional and systemic targeting of heterogeneous midbrain...

Garcia et al. develop intersectional viral-genetic approaches to access molecularly overlapping dopamine and non-dopaminergic neuron subtypes in the mouse midbrain. Their strategy enables selective...

cell.com
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A single-cell spatiotemporal manifold of tissue morphology and dynamics dlvr.it/TVdSpG

A single-cell spatiotemporal manifold of tissue morphology and dynamics

Haus et al. create a learned, embedding-based representation of cell position in developing embryos. Embeddings describe dynamic morphology at the single-cell level, enabling applications in identi...

cell.com
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HisTrader identifies nucleosome-free regions within ChIP-based profiling of histone post-translational modifications dlvr.it/TVY5Lx

HisTrader identifies nucleosome-free regions within ChIP-based profiling of histone post-translat...

Kirbizakis et al. develop HisTrader, a tool that pinpoints the short stretches of accessible DNA, where regulatory proteins bind, from widely available histone modification data. HisTrader enables...

cell.com
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Revealing therapeutic single-cell transcriptomic signatures using a simple classifier dlvr.it/TVY0pm

Revealing therapeutic single-cell transcriptomic signatures using a simple classifier

Gene-expression-based drug screening usually requires at least 50–100 copies of the same clone or cells treated in the same way. Ma et al. describe a single-cell analysis platform that enables the...

cell.com
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Development and application of nbLIBRA-seq for high-throughput discovery of antigen-specific nanobodies dlvr.it/TVXFNM

Development and application of nbLIBRA-seq for high-throughput discovery of antigen-specific...

Leonard et al. present LIBRA-seq for nanobody discovery (nbLIBRA-seq), a method for rapidly screening and discovering antigen-specific nanobodies in alpaca. The approach increases the throughput and...

cell.com
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Moving beyond linear summation to infer interaction order from neural and biological dynamics dlvr.it/TVX84q
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Self-amplifying RNA enables rapid, durable, integration-free programming of hiPSCs dlvr.it/TVWHCk

Self-amplifying RNA enables rapid, durable, integration-free programming of hiPSCs

Self-amplifying RNAs (saRNAs) have the potential for rapid, durable, non-integrating delivery of transgenes in human induced pluripotent stem cells. Della Santina et al. show that transcription...

cell.com
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Parallelized bright-field and fluorescence imaging platform for organoids dlvr.it/TVVNYp

Parallelized bright-field and fluorescence imaging platform for organoids

Kim et al. present a multi-camera array scanner (MCAS) that uses 48 parallel lenses to image organoids. The MCAS reduces acquisition time by 98% compared to commercial systems. The platform enables...

cell.com
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