@ChemBioModific1

Briefly related to peptide and protein modification chemistry | as well as various aspects with chemical probe

Joined July 2020
  • Tweets330
  • Following83
  • Followers200
32Media
ChemBio@Modification retweeted
Bioconjugate Chem@BioconjChem22 Jul 2022
ADCs specifically kill disease cells but are complex molecules with synthetic challenges. Zhang et al conjugate antibodies with two cytotoxic drugs through different functional groups sequentially to produce "dual" payload ADCs for breast cancer treatment go.acs.org/1IH
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ChemBio@Modification retweeted
Spring Group@SpringGroupChem22 Jul 2022
Happy to share our newly accepted manuscript in @ChemCommun: "Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy" doi.org/10.1039/D2CC02515A pubs.rsc.org/en/content/arti…

Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging...

Herein we report the development of a methodology for the dual-functionalisation of IgG antibodies. This is accomplished through the combination of disulfi

pubs.rsc.org
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ChemBio@Modification retweeted
Spring Group@SpringGroupChem21 Jul 2022
We're delighted to share our most recent work in antibody conjugation, featuring all-in-one disulfide bridging using TetraDVP reagents. Now in @ChemicalScience, check it out! doi.org/10.1039/d2sc02198f @ChemCambridge
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London Lab@london_lab21 Jul 2022
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S) nature.com/articles/s41589-0…

Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)

Nature Chemical Biology - The discovery of a strained β-lactone electrophile that covalently targets a KRAS G12 somatic mutation and acylates the mutant serine to suppress oncogenic signaling.

nature.com
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Nice one
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ChemBio@Modification retweeted
Jelena Rnjak-Kovačina@JelenaRnjak8 Jul 2022
Tyrosines are not only useful in #silk crosslinking but in immobilising molecules on preformed silk #biomaterials too. Check out our latest paper led by @FatemehhhKarimi published in @ACS_AMI 👇 @ASBTE1 @MatrixBioANZ @UNSW #BioMedEng @TyreeIHealthE pubs.acs.org/doi/10.1021/acs…
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ChemBio@Modification retweeted
Jeremy Baskin@basktastic18 Jun 2022
Happy to share our latest review, by @weizhi_yu, on the latest advances in using photoaffinity labeling for probing lipid-protein interactions, in Curr Opin Chem Biol. Many thanks to @TsukijiLab & Neal Devaraj for the invitation! doi.org/10.1016/j.cbpa.2022.…
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New team paper led by @DustinTKing, SFU's soon to be newest faculty starting on July 18. Big shout out to the entire team on this long haul project. Looking forward to more fun with gases. nature.com/articles/s41589-0…
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ChemBio@Modification retweeted
Ania Fryszkowska@fryania16 Jun 2022
We keep on asking, #enzymes keep on giving! we asked an acylase to recognize 3 different amines on insulin and today we can share new strategy for enzymatic functionalization of native proteins #directedevolution #bioconjugation #merckchemistry science.org/doi/10.1126/scie…

A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins

Selective enzymatic modification of native proteins enables efficient synthesis of insulin therapeutics.

science.org
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Interesting paper by the groups of @Yang_J_lab and Ping Xu in @JProteomeRes. They directly compared five different cleavable biotin tags and 3 different workflows to characterize their performance in residue-specific chemoproteomics. doi.org/10.1021/acs.jproteom…

Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics

Abstract. Click chemistryspecifically the copper-catalyzed azide-alkyne cycloadditionhas enabled the development of a wide range of

pubs.acs.org
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ChemBio@Modification retweeted
Chemical Communications@ChemCommun29 May 2022
Check out this Communication Article by Injae Shin & first authors Hui Li & Chang-Hee Lee 'A thiol-activated fluorogenic probe for detection of a target protein' Linked below ⬇ rsc.li/3sXwjUO
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ChemBio@Modification retweeted
Michael Smietana@Smietana_M1 Jun 2022
More than 15 years ago we embarked on a project to combine nucleic acid and boronic acid chemistries. This Personal Account describes our contribution to the field ! onlinelibrary.wiley.com/doi/… Thank you The Chemical Record for the invitation ! @ChemBioNAC @umontpellier #OpenAccess

Applications of the Reversible Boronic Acids/Boronate Switch to Nucleic Acids

This personal account summarizes the research carried out in our laboratory at the crossroads of nucleic acids and boronic acids chemistries.

onlinelibrary.wiley.com
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Interesting paper by the group of @ChuWangPKU in @J_A_C_S. An aldehyde probe for site-specific quantification of protein lipoylation in human and bacterial proteomes. The probe forms thioacetals with lipoylated proteins after reduction of the disulfide. doi.org/10.1021/jacs.2c01528
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Nice one. Utilisation of formaldehyde and guanidine moiety for modification of Lysine by cyclisation method.
ProPepChem@ProPepChem31 May 2022
Cool new report on peptide stitching for creating complex macrocycles from @GongChenLab just published in @J_A_C_S pubs.acs.org/doi/10.1021/jac…

Construction of Complex Macromulticyclic Peptides via Stitching with Formaldehyde and Guanidine

Abstract. There is a growing interest in constructing multicyclic peptide structures to expand the chemical space of peptides. Conventional strategies for

pubs.acs.org
ChemBio@Modification retweeted
Malins Lab@Malins_Lab28 May 2022
The group's latest work on peptide macrocyclizations, led by PhD student Hayden Bell @HaydenBChem @ARC_CIPPS @ANUChemistry is out today in @OrgBiomolChem! Congrats, Hayden! Check it out here: pubs.rsc.org/en/content/arti…
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ChemBio@Modification retweeted
Andrei Yudin@andrei_yudin19 May 2022
Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides by ⁦@FujimoriLabUCSF⁩ in @ChemicalScience pubs.rsc.org/en/content/arti…

Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides†

Chemical probes for chromatin reader proteins are valuable tools for investigating epigenetic regulatory mechanisms and evaluating whether the target of in

pubs.rsc.org
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ChemBio@Modification retweeted
ChemBioChem@ChemBioChem19 May 2022
Review: Click Bioconjugation: Modifying Proteins Using Click-Like Chemistry (Stump) @LonzaGroup onlinelibrary.wiley.com/doi/…
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ChemBio@Modification retweeted
Ingo Hartung@HartungIngo10 May 2022
Here is a review about Degrader-ADCs written by Peter Dragovich @genentech. This review is an excellent read based on the significant hands-on experience of the author. And he does a superb job in explaining ADC basics to the lay reader @rsc_medchem #TPD pubs.rsc.org/en/content/arti…
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ChemBio@Modification retweeted
Guillaume Laconde@Glaconde345 May 2022
Degrader-antibody conjugates pubs.rsc.org/en/content/arti…

Degrader-antibody conjugates

Degrader-antibody conjugates (DACs) are novel entities that combine a proteolysis targeting chimera (PROTAC) payload with a monoclonal antibody via some ty

pubs.rsc.org
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ChemBio@Modification retweeted
J. Am. Chem. Soc.@J_A_C_S5 May 2022
Alkyne-Tagged Raman Probes for Local Environmental Sensing by Hydrogen–Deuterium Exchange @CaltechCCE @Caltech #Raman #Probes #Environment #Sensing #Deuterium #Exchange pubs.acs.org/doi/10.1021/jac…

Alkyne-Tagged Raman Probes for Local Environmental Sensing by Hydrogen–Deuterium Exchange

Abstract. Alkyne-tagged Raman probes have shown high promise for noninvasive and sensitive visualization of small biomolecules to understand their function

pubs.acs.org
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