Associate Professor of Cardiovascular Science @UniofOxford. Researching Inherited & acquired heart disease.
Oxford, UK
Joined January 2017
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We have today published a comprehensive set of protocols in @NatureProtocols for assaying the myosin super-relaxed state across tissues, iPSC-CMs and molecules.
rdcu.be/eSysL
@DrRosemaryKirk and @celinefsantiago have had a beautiful review published by @NatureCVR outlining the current landscape of therapeutic upregulation as applied to cardiomyopathy.
nature.com/articles/s44161-0…
This review covers the on-going clinical trials, the future hurdles and historical perspective of therapies in cardiomyopathy.
Christopher Toepfer retweeted
On 25th of September, International Ataxia Awareness Day, we at the Oxford-Harrington Rare Disease Centre stand together with the global Ataxia community on the path towards developing innovative therapeutic approaches.
Functional analysis of TTN uORFs shows that translational regulation is context dependent. tinyurl.com/TTNuORF
1. TTN uORF disruption increased luciferase reporter expression.
2. Endogenous TTN uORF editing using CRISPR/CAS-9 in iPSC-CMs did not increase titin protein.
Conclusions: 1. Although TTN uORFs show repression of expression, they do not measurably alter titin protein expression in the endogenous locus. 2. This highlights the importance of studying regulatory elements in native genomic context and the complexity of TTN regulation.
Thanks to all those that contributed to the work and to our funders @wellcometrust @TheBHF @The_MRC
Work pioneered by: @DrRosemaryKirk
Christopher Toepfer retweeted
New Article! Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery bit.ly/3MzzgqX
Christopher Toepfer retweeted
Thrilled to be the director of the new Center for Space Medicine Research at Cedars-Sinai! 🚀
We study the impact of spaceflight on cell function and harnessing microgravity to make unique bioproducts in space.
Come explore what we’re working on!
cedars-sinai.org/newsroom/ce…
We thank our group of committed and determined collaborators in Denmark and the US that have allowed this set of protocols to be brought together into a single place. Work made possible by our funders @wellcometrust @RDMOxford @TheBHF @Carlsbergfondet @NIH @greentempleton
Christopher Toepfer retweeted
Can you imagine using water droplets to build diodes, transistors and even artificial neuron synapses?
Check out our new paper on #Dropletronics that was published on Science!
science.org/doi/10.1126/scie…
Thanks to all supports @bayley_lab @EPFL_en and the comment from @BaretJc
It’s a pleasure to have Rosie in the lab!
Rosie, 2nd PhD Student: "I mean, it's hard to think of somewhere better for science than Oxford. There's the facilities, there's just this environment of learning, and I've had nothing but support from my supervisors.”
Applications close on 3rd Dec.
#OxfordMedSciGradStudy #PhD