Studying proteins and molecular mechanisms of misfolding and aggregation in Alzheimer's Disease and protein folding disorders at ULisboa
Lisboa, Portugal
Joined March 2019
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Cláudio Gomes Lab - Protein Misfolding in Disease retweeted
Nature research paper: De novo design of cysteine proteases
go.nature.com/4zUMtOP
Cláudio Gomes Lab - Protein Misfolding in Disease retweeted
Out now. A collaboration with Sofia Lövestam, Masato Hasegawa and Sjors Scheres. We report that tau filaments extracted from the brains of individuals with Alzheimer’s disease and corticobasal degeneration breed true in the brains of wild-type mice. nature.com/articles/s41586-0…
What happens when nanobodies developed against a molecular chaperone turn out to selectively inhibit different steps in Tau aggregation? You get chaperone-inspired nanobodies 🧠
In our paper just out in @CommsBio we explore this surprising finding
doi.org/10.1038/s42003-026-1…
These chaperone-inspired nanobodies:
✅ Bind Tau monomers and fibrils
✅ Inhibit Tau aggregation catalytically
✅ Show distinct effects on microscopic aggregation steps
✅ Suppress surface-catalysed secondary nucleation
✅ Attenuate Tau seeding in a cellular biosensor model
Congratulations to first author Margarida Simões, who has just completed her PhD in the lab, and a big thank you to all co-authors
Cláudio Gomes Lab - Protein Misfolding in Disease retweeted
For decades, biology textbooks have enshrined a simple rule: DNA is made by copying a template. After one enzyme unzips a DNA double helix into separate strands, another called a polymerase builds a complementary sequence, base by base, for each strand. Presto: two copies of the original DNA.
But new research into how bacteria defend themselves from viruses now shows this synthesis rule isn’t absolute.
Now, a team describes a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide.
Learn more: scim.ag/4tN5TBR
Cláudio Gomes Lab - Protein Misfolding in Disease retweeted
We've seen the Shingles vaccine is linked with reduced risk of Alzheimer's and dementias in 4 large natural experiments.
Today, the potential of high-dose flu vaccines vs standard dose for the same in a large retrospective age 65+ cohort [N>160,000). More pronounced in women (like Shingles vaccine)
neurology.org/doi/pdf/10.121…
New in @ScienceMagazine 📄Our review explores how protein homeostasis is maintained beyond cellular boundaries proposing #extracellular #proteostasis as a hierarchical network spanning pericellular, tissue, and systemic tiers 🇵🇹🇬🇧 with @mvendruscolo14
science.org/doi/10.1126/scie…
Revisiting the "draw a picture of what you think my current life looks like based on what you know about me" challenge on ChatGPT5, roughly one year after the original
Cláudio Gomes Lab - Protein Misfolding in Disease retweeted
Another great story from Jae Ho Lee in the lab: a new concept in cotranslational proteostasis-ribosome communication via chaperoneNAC. An exciting collaboration with Elke Deuerling's lab @DeuerlingLab and Marina Rodnina's lab biorxiv.org/content/10.1101/…
Cláudio Gomes Lab - Protein Misfolding in Disease retweeted
The brain is the master regulator of food intake and energy balance. A brilliant new @CellCellPress review, including the mechanism of GLP-1 drugs, by @ClemmensenC and colleagues, open-access
cell.com/cell/fulltext/S0092…
📣 Neurons respond to toxic Aβ oligomers by boosting S100B — a Ca-binding chaperone that protects the cytoskeleton and synapses from damage🧠 Collaboration with the Cardoso Lab, spearheaded by our joint PhD student Joana Saavedra 👩🔬👏
frontiersin.org/journals/mol…
International Symposium on Protein Interactions and self assembly 🇵🇹
📣 Day 2 quick off with @LindorffLarsen talk on Predicting condensates of disordered proteins and many others to follow, poster pitches and session and lakeside lunch. #ISPIS2025 @cienciasulisboa @ULisboa_
All set for the start of the 'International Symposium on Protein interactions and self assembly' in Lisbon 🇵🇹 later today. Excited to host an amazing lineup of speakers and 65 participants from all over during the next 3 days! #ISPIS2025 @TWIN2PIPSA @cienciasulisboa @ULisboa_
Cláudio Gomes Lab - Protein Misfolding in Disease retweeted
Did you know that neuroscience played a key role in AI’s development?
Artificial Intelligence: From Mind to Machine explores how brain research led to artificial neural networks, machine learning, and modern AI.
Watch the full documentary: brainprize.org/winners/compu…
Still time to submit an abstract for a short talk! Join us in Lisbon to discuss all things protein — interactions, aggregation, phase separation, and more! 🗓️ Deadline 30 June
📢 International Symposium on Protein Interactions and Self-Assembly
Join us in ☀️ Lisbon 🇵🇹
🗓️ 14–16 July 2025
🗣️ A great programme + short talks selected from abstracts.
🔗 Check it here: twin2pipsa.campus.ciencias.u…
🔬 Powered by #TWIN2PIPSA at @cienciasulisboa
📢 International Symposium on Protein Interactions and Self-Assembly
Join us in ☀️ Lisbon 🇵🇹
🗓️ 14–16 July 2025
🗣️ A great programme + short talks selected from abstracts.
🔗 Check it here: twin2pipsa.campus.ciencias.u…
🔬 Powered by #TWIN2PIPSA at @cienciasulisboa
Just out! A collaboration with the Herrera lab shows that S100B acts as a #chaperone supporting intermediate filament organization, compensating for sacsin loss in a cell model of Autosomal Recessive Spastic Ataxia of Charlevoix–Saguenay (ARSACS) 📄doi.org/10.1007/s12035-025-0…
Cláudio Gomes Lab - Protein Misfolding in Disease retweeted
Instead of listing my publications, as the year draws to an end, I want to put pressure on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research
