@CollerLab

The Coller Lab uses modern approaches to investigate #quiescence, cell cycle control, #autophagy, and #cancer. Official account managed by the lab members.

 UCLA
collerlab.dgsom.ucla.edu
Joined November 2021
  • Tweets67
  • Following186
  • Followers127
28Media
Coller Lab retweeted
Shom Goel@shomgoelSep 7
A nice follow-up to our recent @Nature paper (@BarbMarte). Nature has published a News & Views piece discussing the work: “The secret life of a cell-cycle gatekeeper of cancer.” Very proud of the team. Interested to hear where these concepts go next. nature.com/articles/d41586-0…

The secret life of a cell-cycle gatekeeper of breast cancer

Nature - A newly discovered function for the protein Rb explains why inhibiting cell division can enhance the signalling mediated by the oestrogen receptor that drives breast cancer.

nature.com
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Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉 How do cells coordinate RNA processing with nuclear organization and the cell cycle? nature.com/articles/s41556-0… 1/10
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Coller Lab retweeted
Di Jiang@dijiang319Sep 10
Online today @ScienceMagazine Noncoding transcription controls the developmental dynamics of long-range gene regulation | Science science.org/doi/10.1126/scie…

Noncoding transcription controls the developmental dynamics of long-range gene regulation

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely...

science.org
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Coller Lab retweeted
Itai Yanai
@ItaiYanaiJun 24
🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly
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⭐️Check out the Perspective on cellular neighborhoods in cancer by @LichunMa, @KaiTanLab1 & co 🔗nature.com/articles/s43018-0… Part of our Series on Tumor Heterogeneity and Plasticity: nature.com/collections/gfbbj…
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Check out the latest from @Rachel_E_Savage, @JD_Buenrostro and many collaborators as part of the @IGVFConsortium
Rachel Savage@Rachel_E_SavageApr 23
It takes two (transcription factors) to tango Transcription factor collaboration enables precise T cell state engineering tinyurl.com/tcelltfs Excited to share our preprint with @JD_Buenrostro, @cgersbach, and an incredible team of collaborators as part of @IGVFConsortium 🧵
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Coller Lab retweeted
Nature Cancer@NatureCancerMay 5
⭐️Don't miss this Review published @NatureCancer as part of our Series on Tumor Heterogeneity and Plasticity 'Heterogeneity and plasticity of cancer-associated fibroblasts' ✒️By Ruth Scherz-Shouval, Mara Sherman and co-authors 🔗nature.com/articles/s43018-0…

Heterogeneity and plasticity of cancer-associated fibroblasts

Nature Cancer - Sherman and colleagues provide an overview of the current understanding of the heterogeneity and plasticity of cancer-associated fibroblasts.

nature.com
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Coller Lab retweeted
Aparna Bhaduri@BhaduriLabFeb 25
(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇 biorxiv.org/content/10.64898… biorxiv.org/content/10.1101/…
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We are excited to release a single-cell and spatial 3D epigenomic atlas of developing human basal ganglia and inhibitory neurons, part of our BICAN effort in collaboration with @lab_paredes @jernst98 @emukamel @CEpigenomics @bpasaniuc biorxiv.org/content/10.64898…
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Coller Lab retweeted
Thomas Rando@Thomas_RandoFeb 1
Excited to share a recent publication from the lab. Daniel Benjamin & Jengmin Kang led the study of the allocation of resources to survival over reproduction in stem cells during aging. #EvolutionaryTradeOffs #SurvivorshipBias science.org/doi/10.1126/scie…

Cellular survivorship bias as a mechanistic driver of muscle stem cell aging

Aging is characterized by a decline in the ability of tissue repair and regeneration after injury. In skeletal muscle, this decline is largely driven by impaired function of muscle stem cells (MuSCs)...

science.org
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H4K20me3 and CTCF act reciprocally at TAD boundaries to regulate cell state transitions biorxiv.org/content/10.64898… #biorxiv_cellbio
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We are so happy that Michael Cheng, a former undergraduate researcher in the lab and now a bioinformatics graduate student at @UCLA , will be defending his thesis this week (Wednesday at 1 pm; in person and on zoom). All the best, Michael!
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🆕🎧 New Podcast: The founding of PG is discussed in interviews with Drs. AW Cowley, Jr., B Joe, and HA Coller. These interviews were organized and conducted by @AkinolaTosinS. Listen at ow.ly/L0MQ50Xok2H. Read the article at ow.ly/Vrxx50Xok2G.
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Coller Lab retweeted
Rong Fan@RongFan817 Sep 2025
New @NatureGenet review from our NIH SenNet ⁦@sennetresearch OMICS WG co-led by ⁦@shenglilab⁩ ⁩ We share practical considerations for identifying, characterizing & spatially mapping #CellularSenescence, plus computational #multiomics insights!! nature.com/articles/s41588-0…

Advancing biological understanding of cellular senescence with computational multiomics

Nature Genetics - This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and...

nature.com
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Years ago we tried to model cancer-associated fibroblast (CAF) subtypes in vitro, but gave up because only the proliferative subtype survived culture (duh!). This study could change all that: Perturb-seq with CRISPRa of 1,836 TFs induces diverse fibroblast states in vitro(!). 👏
Anirban Maitra@Aiims174210 Oct 2025
Fantastic work by @thenormanlab in @NatureGenet Recreating fibroblast diversity in vitro by activating transcription factors Demonstration of the power of CRISPRa Perturb-Seq to deregulate TF expression in fibroblasts (Function!) nature.com/articles/s41588-0… nature.com/articles/s41588-0…
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Coller Lab retweeted
Patrick Hsu
@pdhsu10 Oct 2025
A new bridge recombination edit just dropped! 👀
Eric Topol
@EricTopol9 Oct 2025
Why does the naked mole rat have the longest lifespan and healthspan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation science.org/doi/10.1126/scie…
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Dr. Hilary Coller (@CollerLab) discussed her latest research on how epigenetic patterns can predict cancer outcomes more accurately than traditional markers. Her pan-cancer model reveals targetable epifactors across five tumor types. Watch the talk here: bit.ly/4jEAMTU
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Join us for our next seminar with Dr. Hilary Coller of @UCLA! ➡️ youtube.com/watch?v=3bh0M98x…
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Coller Lab retweeted
Wei Xie@xielablife23 Feb 2025
Less than one month away from abstract submission deadline for the 2025 GRC/GRS Genome Architecture meeting at the beautiful beach in California. Don't miss it!
Wei Xie@xielablife20 Jan 2025
Chromatin folks: don't miss GRC/GRS Genome Architecture in Cell Fate and Disease, June 15-20 2025 Ventura, CA. Registration deadline: Mar 18, 2025. grc.org/genome-architecture-…
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Kaiser is going to defend this doctoral thesis next week (Thursday, February 27th) at 9 AM in 158 Hershey Hall. Everyone is welcome to attend.
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