A feed for the blog https://xitter.cf/t.co/pXYAKACULR. Discusses the covalent modification of proteins. Available on bsky and mass std don

Ottawa, Ontario
Joined April 2017
An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes dlvr.it/TDdBNg
4
15
1,607
Selective Covalent Inhibiting JNK3 by Small Molecules for Parkinson's Diseases dlvr.it/TDQ5zm
9
2
27
2,742
Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads dlvr.it/TDDqbG
5
14
1,641
From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling dlvr.it/TCpjGx
3
1
13
1,985
SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex dlvr.it/TCglxQ
1
11
1,624
Targeted Protein Localization by Covalent 14–3–3 Recruitment dlvr.it/TCVVQX
6
1
29
2,551
Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network dlvr.it/TCP1hT
4
29
2,249
Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis dlvr.it/TCCVwB
4
7
1,101
Discovering Covalent Cyclic Peptide Inhibitors of 2 Peptidyl Arginine Deiminase 4 (PADI4) Using mRNA3 Display with a Genetically Encoded Electrophilic 4 Warhead dlvr.it/TC6Xvf
6
1
21
3,818
Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling [@RulloLab] dlvr.it/TBwHWd
3
18
2,375