@DEOlsonLab

We develop plasticity-promoting neurotherapeutics through a combination of chemistry, molecular/cellular biology, and behavioral neuropharmacology.

olsonlab.org/
Joined September 2020
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Exciting new research in @ScienceMagazine from the labs of IPN researchers @tinakim_neuro @DEOlsonLab reveals that the neural circuitry mediating the anti-anxiety and hallucinogenic effects of #psychedelics are distinct. @UCDavisCNS @UCDLandS @UCDavisMed science.org/doi/10.1126/scie…

Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states

Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the...

science.org
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Exciting news! We've launched a crowdfunding campaign for a new art installation in the Chemistry Building! 🎨 Help us raise $5,000 for the amazing artists! Every contribution and share counts. Let’s create something extraordinary! 🙌💙 Join us: shorturl.at/jL8rb
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IPN faculty affiliate @tinakim_neuro and team just published in @naturemethods about a protein-based tool expected to aid in identifying how #psychedelics impact brain disorders by tagging neurons activated by psychedelics. nature.com/articles/s41592-0…

Rapid, biochemical tagging of cellular activity history in vivo

Nature Methods - CaST is a Ca2+-activated version of split-TurboID. The tool allows labeling active neurons quickly, simply by administration of exogenous biotin, thus enabling the study of...

nature.com
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The newest research from IPN Director @DEOlsonLab and team suggests that tropane analogs can promote #neuroplasticity with fewer side effects than compounds like scopolamine. Read more here: pubs.acs.org/doi/10.1021/acs…

Identification of Psychoplastogenic Tropanes Lacking Muscarinic Activity

Abstract. Tropane-containing small molecules like scopolamine are a promising class of psychoplastogens. However, their potent antagonism of all muscarinic

pubs.acs.org
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Check out the latest IPN paper in J. Med. Chem. on the development of psychoplastogenic DYRK1A inhibitors with potential for treating Alzheimer's disease especially early-onset Alzheimer's disease associated with Down Syndrome pubs.acs.org/doi/10.1021/acs….

Psychoplastogenic DYRK1A Inhibitors with Therapeutic Effects Relevant to Alzheimer’s Disease

Abstract. Tauopathy, neuronal atrophy, and psychological impairments are hallmarks of neurodegenerative diseases, such as Alzheimer’s disease, that current

pubs.acs.org
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@UCDavisIPN Director @DEOlsonLab talks about psychedelics and nonhallucinogenic psychoplastogens on the @UChicago's Big Brains podcast news.uchicago.edu/psychedeli…

Psychedelics without the hallucinations: A new mental health treatment? with David E. Olson

Scientist examines how non-hallucinogenic drugs could be used to treat depression, addiction and anxiety

news.uchicago.edu
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IPN director @DEOlsonLab was interviewed for this PNAS news feature on the mechanisms of psychedelics pnas.org/doi/10.1073/pnas.23…

If psychedelics heal, how do they do it? | PNAS

If psychedelics heal, how do they do it?

pnas.org
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Within #psychedelic science, the debate lingers: Is it mind-blowing experiences or powerful #molecules that spur change? Join @TTBOOK to hear David E. Olson's take. Also available on @Spotify! youtu.be/JunhDmkrM88?si=OzEE…
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This work was led by the very talented PhD student @RunChesterZhang, with help from many more in our lab. A great example of tool engineers and neuroscientists working together. Also thanks to @DEOlsonLab! We're getting plasmids up on Addgene, but reach out if you can't wait! 6/6
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How do researchers strip a #psychedelic of its hallucinogenic properties? David Olson (@DEOlsonLab), founding director of @UCDavisIPN, walks us through the chemical evolution of these revolutionary compounds: lettersandscience.ucdavis.ed… #UCDavis #psychedelicscience #mentalhealth
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Could "tripless" #psychedelics be the future of therapy? Discover how these drugs are reshaping #psychiatry while opening new doors for mental health treatments. vox.com/future-perfect/23801… via @voxdotcom

Psychedelics might revolutionize therapy. What happens if you remove the trip?

“Tripless” drugs might open more opportunities for psychiatry. Just don’t call them psychedelics.

vox.com
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Excited to share the lab's latest #bioinorganic work in @J_A_C_S showing that copper can facilitate complexation of C-peptide and albumin, offering important implications on C-peptide's biological activity and application as a biomarker. pubs.acs.org/doi/full/10.102…

Copper(II) Affects the Biochemical Behavior of Proinsulin C‑peptide by Forming Ternary Complexes...

Abstract. Peptide hormones are essential signaling molecules with therapeutic importance. Identifying regulatory factors that drive their activity gives im

pubs.acs.org
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Prof. Mark Geyer delves into the fascinating world of #Neuropsychedelia, tracing its journey from #Psychotomimetic to #Psychotherapeutics. Don't miss his enlightening lecture from the 2023 UC Davis #Psychedelic Summit. youtu.be/WZ2SXTrrXGg
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Replying to @ucdavis
@ucdavis alum @FredBarrettPhD takes over as the director of the @JHPsychedelics center.  Congrats Fred!
Johns Hopkins Psychedelic Research Center
@JHPsychedelics20 Jun 2023
The Johns Hopkins Center for Psychedelic & Consciousness Research is pleased to announce the appointment of Frederick S. Barrett, PhD, as its new Director, effective immediately. Join us in congratulating Dr. Barrett on this new role. Press release: hopkinsmedicine.org/news/new…
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IPN director @DEOlsonLab comments on a recent study from the group of @castren_eero about #psychedelics binding to TrkB inverse.com/health/lsd-magic…

LSD and Magic Mushrooms Dramatically Rewire the Brain, New Study Reveals

LSD and psilocin target a biochemical pathway that may confer mental health benefits by encouraging new neural connections.

inverse.com
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The Institute for Psychedelics and Neurotherapeutics is actively recruiting for a Director of Medicinal Chemistry & a Director of Pharmacology! Apply or share with qualified individuals today! #OurUCDavis ipn.sf.ucdavis.edu/join-our-…
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Way to go North Carolina! $4 Million for research proposal on psilocybin and MDMA for PTSD, depression and anxiety. #psychedelics
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FYI, Sophia has a psychedelics podcast PsychExchange. Check it out! One of the first interviews is with a former colleague Dr. Lindsay Cameron. psychexchangepodcast.com/

Home - Psych Exchange

PsychExchange Where psychedelic research and biotech collide.PsychExchange is a collection of in-depth conversations about psychedelic academia and biotechnology. We aim to supply biotech-savvy...

psychexchangepodcast.com
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The #psychedelics section includes outstanding reviews on Classical and Non-Classical Psychedelics & Entactogens by Dr. Jenny Mitchell and Dr. Brian Anderson (Clinical) @TheBorisLab @DEOlsonLab (Mechanisms) and @rgumpper @zenbrainest (Future Potential) Online now 👇 Stay tuned!
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