@DJCalebC

✝️🇹🇼🇺🇸MD/PhD candidate studying pancreatic cancer in @Chinnaiyanlab and @Lyssiotislab at @UmichMedSchool

 Ann Arbor, MI
Joined December 2019
  • Tweets920
  • Following618
  • Followers573
68Media
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@LyssiotisLab @ArulChinnaiyan), has just been published in @Nature! @UMRogelCancer @UMICHpancreas @UMichMedSchool @UMichPath @UMichResearch @UMichCMB
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Excited to share that our recent work was just published in @CR_AACR !
Cancer Research@CR_AACRSep 22
Now online: Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Cancer doi.org/10.1158/0008-5472.CA…
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Caleb Cheng retweeted
Genes & Development@GenesDevOct 1
🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also in this issue, two additions to our collection of Reviews on Cancer Metabolism, and more... Click here to learn more: ➡️ genesdev.cshlp.org/content/4…
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Caleb Cheng retweeted
Genes & Development@GenesDevOct 2
CANCER METABOLISM REVIEW: Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology By Cheng et al. and Costas Lyssiotis ➡️ genesdev.cshlp.org/content/4… @DJCalebC @Chinnaiyanlab @LyssiotisLab #pancreaticcancer #metabolism #lysosome
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Very happy and and honored to have gotten the chance to write this review with my friend Rüya and my mentors @LyssiotisLab @Chinnaiyanlab! It summarize much of the literature foundation of my PhD and highlights work from amazing scientists that have come before. Check it out!👇👇
Genes & Development@GenesDevSep 25
🆕 ADVANCE ONLINE 🆕 CANCER METABOLISM REVIEW: Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology By Cheng et al. and Costas Lyssiotis ➡️ ow.ly/2Mjl50ZRavt @DJCalebC @Chinnaiyanlab @LyssiotisLab #pancreaticcancer #metabolism #lysosome
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Trying to investigate lysosomal cycling in #PDAC? This review from Dr. Costas Lyssiotis' team (@LyssiotisLab) at @UMich has you covered! Check it out for the scoop on: -Current tools and concepts -Therapeutic opportunities -Emerging metabolic insights 📰 bit.ly/4zph8nD
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Caleb Cheng retweeted
Cancer Cell@Cancer_CellAug 3
Online Now: A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer dlvr.it/TTrBxR
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Caleb Cheng retweeted
nature
@NatureJul 21
The ‘24-hour rule’ and other tips from sport can improve lab life, says Megan Cooke go.nature.com/3TL4gI6

Seven ways endurance sports have taught me to be a better researcher

Nature - The ‘24-hour rule’ and other tips from sport can improve lab life.

nature.com
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Wow!!
Rogel and Blondy Center for Pancreatic Cancer
@UMICHpancreasJun 22
Big news in pancreatic cancer! The Rogel and Blondy Center for Pancreatic Cancer at University of Michigan is proud to announce we have obtained access to daraxonrasib through the expanded access program.
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Caleb Cheng retweeted
Anirban Maitra@Aiims1742Jun 19
Congratulations to the four organizers of @CSHL 2026 #PancreaticCancer workshop (which began 15 years ago in 2011). A multi day immersion in pancreatic cancer research and clinical care for a select cohort of trainees. @MaraShermanLab @KenOliveLab @BenStanger01 @Pasca_Lab
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Caleb Cheng retweeted
Anirban Maitra@Aiims1742Jun 20
RAS inhibitors in clinical development From @papkephd’s website: rasinhibitors.com
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RESEARCH | @YatrikShahLab, H Crawford, @LyssiotisLab et al. (U of Michigan): Disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions. dlvr.it/TSQjRX

NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions

Nature Metabolism - Temporal profiling of central carbon metabolism during KrasG12D-driven acinar-to-ductal metaplasia reveals that disruptions in NADPH-producing enzymes accelerate the formation...

nature.com
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Caleb Cheng retweeted
Tom Hur
@KoreaPistonsFanMay 3
18 years. Detroit had to endure 18 years without a playoff series win. Everyone called us a fraud #1 seed. We deserve this win!!! DEEEETROIT BASKETBALL!!!!
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Last evening we celebrated the installation of Filip Bednar, MD, PhD as the Maud T. Lane Research Professor in Surgical Oncology. A distinguished pancreatic surgeon, brilliant researcher and highly respected teacher and mentor. Congratulations, Dr. Bednar! @Fil_Bednar @timofran1 @LyssiotisLab @Pasca_Lab
Filip Bednar Professorship Ceremony

ALT Filip Bednar Professorship Ceremony

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Thanks for all your support @LyssiotisLab!!! 🤩👑
Lyssiotis Lab
@LyssiotisLabApr 29
A magnificent presentation from @DJCalebC, capping off a remarkable PhD 💪🏼 GOAT status 🐐 @Chinnaiyanlab, @yuanyuan_qiao, @UMCDB, @UMICHpancreas, @UMRogelCancer
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24 hrs left I better finish my slides soon 🥶😬
Caleb Cheng@DJCalebCApr 24
My defense is in 4 days on Tuesday April 28th at 2PM!! I made an unofficial flyer and my department made an official one. Which is better?? (Btw love my committee and professors I am not scared of them) Please feel free to join! Zoom link available by QR in the official one 😁
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My defense is in 4 days on Tuesday April 28th at 2PM!! I made an unofficial flyer and my department made an official one. Which is better?? (Btw love my committee and professors I am not scared of them) Please feel free to join! Zoom link available by QR in the official one 😁
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Thesis submitted! Time to mount an epic defense.
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Unprecedented overall survival benefit from Phase 3 RASolute 302 in previously treated metastatic pancreatic cancer. Read the press release: ir.revmed.com/news-releases/… #Oncology #PancreaticCancer
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Caleb Cheng retweeted
Anirban Maitra@Aiims1742Apr 13
That Phase 3 overall survival data is in second line #PancreaticCancer which makes the numbers even more astounding. I cannot recall any other example in pancreatic cancer when OS in a Phase 3 trial basically doubled over existing standard of care. statnews.com/2026/04/13/revo…

Revolution Medicines touts ‘unprecedented’ data for pancreatic cancer pill

In a trial, metastatic pancreatic cancer patients on the medicine lived twice as long as those on chemotherapy.

statnews.com
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Caleb Cheng retweeted
Anirban Maitra@Aiims1742Apr 13
🚨🚨🚨 RASOLUTE-302 Ph3 is POSITIVE "Daraxonrasib demonstrated a median OS of 13.2 months versus 6.7 months for chemotherapy, with a hazard ratio of 0.40 (p < 0.0001)".... WOW! AMAZING news for patients with #PancreaticCancer The RAS Revolution is ON!! ir.revmed.com/news-releases/…

Daraxonrasib Demonstrates Unprecedented Overall Survival Benefit in Pivotal Phase 3 RASolute 302...

Trial met all primary and key secondary endpoints, including progression-free survival and overall survival Company intends to include these data in a future New Drug Application submission to the...

ir.revmed.com
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