@DMM_Journal

Disease Models & Mechanisms - discovery for human health. A @Co_Biologists Open Access journal that publishes human disease research.

 Cambridge, UK
journals.biologists.com/dmm
Joined September 2009
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*** Call for papers deadline extended *** Submit your latest #Paediatric #GeneticDiseases paper to be included in our next special issue. The deadline has been extended to 7 December 2026. Find out more today 👇️ tinyurl.com/3b8zscaz
Call for papers - Special Issue - Paediatric Genetic Diseases: Models, Mechanisms and Therapies. Edited by James Amatruda, Ross Cagan and Elaine Mardis. Extended deadline: 7 December 2026.

ALT Call for papers - Special Issue - Paediatric Genetic Diseases: Models, Mechanisms and Therapies. Edited by James Amatruda, Ross Cagan and Elaine Mardis. Extended deadline: 7 December 2026.

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For your #WeekendRead - Tracey Murray Stewart and colleagues present an improved mouse model of #SnyderRobinsonSyndrome, providing a robust platform for therapy testing. Read and share the article for free doi.org/10.1242/dmm.052953
Effects of the SmsG56S allele on regional protein expression in the brain

ALT Effects of the SmsG56S allele on regional protein expression in the brain

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Today is #BreastCancerAwareness #WearItPink day. In our interview with Funmi Olopade, she talks about her serendipitous research path, improving care for breast cancer patients and the heroism of women in genetics. doi.org/10.1242/dmm.049198

Doing better and being better in breast cancer care: an interview with Funmi Olopade

Dr Olufunmilayo (Funmi) I. Olopade, FAACR, is the Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics and Director of the Center for Clinical Cancer Genetics and Global...

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Claes Fryklund & co use longitudinal metabolic phenotyping to identify a fixed-dose streptozotocin protocol that produces a stable type 2 diabetes-like phenotype in high-fat-diet-fed mice. Check out this article for free in DMM: doi.org/10.1242/dmm.053071
Mathematical modelling of STZ intervention in mice. Schematic representation of the mathematical model structure.

ALT Mathematical modelling of STZ intervention in mice. Schematic representation of the mathematical model structure.

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‘Why is publishing so expensive?’ This year’s theme for #OAweek is #TheCostOfKnowledge - an opportunity to revisit the Editorial where DMM, a fully Open Access journal, is transparent about its publishing finances: journals.biologists.com/dmm/…

‘Why is publishing so expensive?’

For many of us who work in scientific publishing, the title of this Editorial is a question we hear all the time when we're out talking to academics. And it's a perfectly reasonable one. After all,...

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We're still celebrating #OAweek: Our subject collections of #openaccess reviews and research articles make it easy to browse your favourite topics: journals.biologists.com/dmm/…
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Ignacio Simó and colleagues find polyQ-expanded ataxin-3 is associated with mitochondrial alterations in #MachadoJosephDisease Read the Research Article for free: doi.org/10.1242/dmm.052757
Primary cortical neuron cultures from CMVMJD135 and WT embryos and analysis of mitochondrial and metabolic markers.

ALT Primary cortical neuron cultures from CMVMJD135 and WT embryos and analysis of mitochondrial and metabolic markers.

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To find out more about this research, check out the #FirstPerson interview with Ignacio, a postdoc in the lab of @AngelaSLaird at Macquarie University, investigating mitochondrial dysfunction, cellular metabolism and m6A RNA regulation doi.org/10.1242/dmm.053121
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Celebrate #OAweek 2026 with DMM. Learn more about DMM's Open Access policies journals.biologists.com/dmm/…
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Female-specific alterations in insulin dynamics are associated with glucose tolerance in a Glut1DS mouse model Check out the article by Tamio Furuse & co: doi.org/10.1242/dmm.052836
Glucose-related features measured in clinical blood chemistry test.

ALT Glucose-related features measured in clinical blood chemistry test.

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Thank you to organisers James Amatruda, Pratiti (Mimi) Bandopadhayay, Ana Banito and Elaine Mardis and everyone who joined us last week for our meeting on Innovative Preclinical Models for Pediatric Cancer Research #DMM2026cancer
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For your #WeekendRead this #BreastCancerAwarenessMonth - Functional exploration of copy number alterations in a Drosophila model of triple-negative breast cancer. Read the article by Diaz et al: doi.org/10.1242/dmm.050191

Functional exploration of copy number alterations in a Drosophila model of triple-negative breast...

Editor's choice: Modeling of triple-negative breast cancer (TNBC) is challenging owing to the predominance of copy number variations. Here, we combined computational and Drosophila modeling to...

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Eduardo Vieira Neto and colleagues characterise the #cardiomyopathy developed by a mouse model carrying a mutation in the β-subunit of mitochondrial trifunctional protein Read and share for free: doi.org/10.1242/dmm.052921
Myocardial interstitial fibrosis in a homozygous βTFP-deficient mouse with the highest collagen fraction.

ALT Myocardial interstitial fibrosis in a homozygous βTFP-deficient mouse with the highest collagen fraction.

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DMM Editors - Jim Amatruda, Steve Clapcote, Elaine Mardis, Liz Patton and Karen Liu - at the DMM meeting earlier this week, exploring Nationwide Children’s Hospital @nationwidekids in Columbus, Ohio. nationwidechildrens.org/
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Thank you to everyone who made the DMM meeting on Innovative Preclinical Models for Pediatric Cancer Research a success! See our wonderful venue all set for presentations below - Nationwide Children’s Hospital Conference Center - and Columbus looking beautiful in the sun ☀️
Columbus, Ohio in the sun

ALT Columbus, Ohio in the sun

A conference room, set up with a slideshow and empty chairs on the stage for a panel talk

ALT A conference room, set up with a slideshow and empty chairs on the stage for a panel talk

A room full of delegates sat in rows listening to a talk at the conference

ALT A room full of delegates sat in rows listening to a talk at the conference

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The Company of Biologists is a not-for-profit publisher that exists to support biologists and inspire biology. This video tells you more about our aims and activities. youtu.be/lVH6zgfl-zM

The Company of Biologists: who we are and what we do

The Company of Biologists is a not-for-profit publisher. This video...

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Luiza Albuquerque Coelho & co investigate progressive impairment of muscle regeneration in the dy2J mouse model of LAMA2-related muscular dystrophy. Read the Research Article for free in DMM: doi.org/10.1242/dmm.052782
Newly regenerated fibers in dy2J groups.

ALT Newly regenerated fibers in dy2J groups.

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Find out more about this research in the #FirstPerson interview with Luiza Coelho, now a Master's student investigating muscle regeneration in health and disease and the factors that modulate this process. doi.org/10.1242/dmm.053198
Luiza Coelho

ALT Luiza Coelho

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Why Luiza chose DMM: “DMM's open-access policy and the fact it's published by The Company of Biologists, a not-for-profit organization, were essential to our decision, as I strongly believe that making scientific knowledge accessible is key to the advancement of science.”
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Fuelling repair: metabolic regulation of alveolar type 2 cell fate in lung regeneration and disease. Check out this #Review by Sophia Wugk & co. doi.org/10.1242/dmm.052978
Dysregulated AT2 cell metabolism is associated with impaired regeneration in ageing and chronic lung diseases.

ALT Dysregulated AT2 cell metabolism is associated with impaired regeneration in ageing and chronic lung diseases.

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This #BreastCancerAwarenessMonth, check out the article by Jun Nakayama and colleagues, who identified two cancer stem cell-like populations in triple-negative breast cancer xenografts. doi.org/10.1242/dmm.049538 #BCAM

Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts

Summary: We identified two types of cancer stem cell (CSC)-like populations in triple-negative breast cancer xenografts and patients. These CSC-like populations could potentially make tumors more...

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