Translation Immunology Lead

CRUK Cancer Biomarker Centre
Joined July 2022
#teamscience with @ER_Woodward @davidcwedge @JamieMJWeaver and @EllenLanger2 (and we have a opening for a clinical fellow and students to join this wonderful team)
Replying to @claus_jorgensen
@claus_jorgensen is featured in the Manchester Evening News discussing a new project on pancreatic ductal adenocarcinoma, which aims to pave the way for early diagnosis and intervention to improve survival rates for this most common type of pancreatic cancer.
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A huge thanks to everyone who joined us for the Colloquium last week! We had 3 amazing days of scientific exchanges, featuring plenary sessions from Jos Jonkers and Margaret Frame, plus talks from our faculty and students. A highlight was seeing the Northern Lights in Buxton! ✨
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David Millrine retweeted
Exciting to see our @kadochlab and @Oser_Lab collaborative study focused on mSWI/SNF chromatin remodeling complexes in small cell lung cancer out in @Cancer_Cell! This is one of 4+ studies published/soon to be published highlighting the potential for #BAF disruption in SCLC!
Excited to see our collaborative work with @Oser_Lab @DanaFarber @DanaFarberNews on #SCLC #lungcancer out in @Cancer_Cell, identifying chemically targetable #BAFcomplex chromatin regulatory dependencies and providing foundation for new clinical studies for this aggressive cancer.
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And the guest of honour - Professor Sir Paul Nurse takes to the stage reflecting on the shock of the fire and the Phoenix that arose from the ashes. What a wonderful opening!
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David Millrine retweeted
Branched #ubiquitin has important roles in cell signaling but are very challenging to study due to complexity & lack of tools. We tackle this challenge in our latest study @NatureSMB developing a toolkit enabling discovery of molecular players and pathways rdcu.be/dM5nn
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Friday saw the official launch of the @CR_UK National Biomarker Centre - an exciting day with lots of visitors & special guests getting behind-the-scenes tours of the research labs 🥼 See @cruk_nbc for photos of the day & take a look at cruknbc.org/ for further info
What. A. Day! Thank you to all our funders, donors, collaborators & friends for joining us today. We absolutely loved seeing you all and celebrating our launch. We were absolutely honoured to welcome @AndyBurnhamGM to our labs. Thank you for visiting us! (1/2)
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Some of our senior management team are excited to be sharing our research today! Here we have Dominic, Ekram, Florent and David!
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It’s our launch day!! 🥳
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It's been a busy day for @CRUK_MI and @cruk_nbc #PhD students at the EACR conference @EACRnews! Victoria's work "COX-2-associated inflammation as a relapse #biomarker for early-stage lung cancer" is presented at Poster P033 #EACR2024
Interested in novel #biomarkers in tissue and blood? Find Victoria Fife's poster at #EACR2024 to explore COX-2-associated inflammation to predict outcome for early-stage #LungCancer patients. @cruk_nbc | @EACRnews | #CRUKFunded
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David Millrine retweeted
Comment: Capturing heterogeneity in PDX models: representation matters nature.com/articles/s41467-0…
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We have a new position in our team at @cruk_nbc for a computational biologist (post-doctoral level). Focus on developing methods for exploring #fragmentomic transcriptomic and other omics to unlock new cancer biomarkers. cruknbc.org cruk.manchester.ac.uk/recrui…
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HIRING: Bioinformaticians/Computational Biologists. Joining our Bioinformatics & Biostatistics Team, you'll focus on implementing/developing bioinformatics pipelines &/or computational tools & apply them to sequencing data generated across our projects! cruk.manchester.ac.uk/recrui…
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Fantastic work from @cruk_nbc in developing a new blood test to help improve the diagnosis of patients with Cancer of Unknown Primary Read the whole paper to see the meticulous #Bioinformatics and sophisticated assay development which demonstrates the power of #TeamScience
**NEW PAPER** We have developed a blood test to determine the primary tumour for patients with CUP addressing an unmet medical need. This has the potential to give hard to treat patients access to personalised medicines & improve clinical outcomes. rdcu.be/dEZ9T
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We have an exciting #PhD opportunity in the Leukaemia Immunology and Transplantation research group studying T Cell Responses in Acute Myeloid Leukaemia (#AML) cruk.manchester.ac.uk/Educat… 🗓️Apply by 17th May Current #PhDStudent @FlorMousoullou explains some of the lab's research:
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🚨Junior Group Leader Recruitment🚨 In this latest short clip of the series, Prof Caroline Dive & @claus_jorgensen talk about how research on tumour microenvironment is going on in the Institute If this covers your research area, check out our job advert! nature.com/naturecareers/job…
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I am super excited - we are recruiting a new Junior Group Leader at @CRUK_MI !! Are you looking to start your independent career with fantastic colleagues in a supporting environment with outstanding infrastructure, then have a look here: nature.com/naturecareers/job… Please RT
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David Millrine retweeted
In Dundee this evening and the box office are concerned that a percentage of the audience will get something they weren’t expecting ….
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A paradigm-shifting study led by our researchers, in collaboration with @helsinkiuni, @MassGeneralNews, and the @broadinstitute of MIT and Harvard, sheds light on how variations in immune genetics influence #LungCancer risk, potentially paving the way for enhanced prevention strategies and screening: mshs.co/3URPPRa @MiriamMerad @SinaiImmunol @diegochowell @rsamstein @chirag_msk @MiriamSaffern @HannaMOllila @EricWil39327976 @fran_mj88 @evotobi @VRoudko @ninajmars @AnniinaTervi @PaoloBoffett @ZeynepHG @drsamuelejones @uk_biobank @FinnGen_FI
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Replying to @joshuajk2007
@joshuajk2007 @YKulathu This is really a remarkable ans brilliant study. Congratulations
Excited to share our latest work shedding light on the mechanism of how the UFM1 E3 ligase complex recognizes, UFMylates and releases the ER-bound ribosomes from the translocon. A short thread 🧵 nature.com/articles/s41586-0…
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