@DamhaLab

Nucleic Acid Chemistry Lab @McGillU Home of the FANAtics Studying the effects of chemically modified oligos on synthesis/structure/therapeutics.🧬 student-run

 Montréal, Québec
damha-group.mcgill.ca
Joined September 2017
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Presenting... the Oligonucleotide Therapeutics Society's 20th Annual Meeting Sessions For the full agenda, visit: 2024oligomeeting.com/meeting… #ots24 #ots #oligomeeting #oligotherapeutics #oligonucleotides #montreal #canada
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Rosalind Franklin U@RFUniversity25 Apr 2024
On #DNADay, we commemorate Dr. Rosalind Franklin's Photo 51, an x-ray diffraction image that was not just a scientific breakthrough, but a revelation. It unveiled the double helix of DNA, a discovery that fundamentally changed our understanding of life's inheritance.
A black and white photograph of Dr. Rosalind Franklin looking into a microscope in a lab

ALT A black and white photograph of Dr. Rosalind Franklin looking into a microscope in a lab

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Masad J. Damha@F_ANAtico28 Mar 2024
Building short DNA/RNA fragments by Resonance Acoustic Mixing (RAM). Thanks @JamesDThorpe and of J. Marlyn @DamhaLab and S. Koenig @genentech). Also special thanks to @TomislavFriscic lab for his encouragement and showing us the way to @Mechanochem doi.org/10.1039/D4MR00009A
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Scott Bagley@BagPhos20 Mar 2024
Our last speaker is Dr. James Thorpe from the @DamhaLab @McGillChemistry discussing preparing oligonucleotides with #MechanoChemistry
Scott Bagley@BagPhos8 Mar 2024
Join us in NOLA for #ACSSPring2024!!! The @ACSorganic (ORGN) division is proud to present the 2024 ACS Award for Affordable Green Chemistry to Dr. K. Nagapudi and Dr. S. Koenig @genentech and Prof. T. Friščić @TomislavFriscic Wednesday 3/20 8 am Rm 344 Morial CC, NOLA
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Meet our new PROMOTE trainee reps for 2024-2026: Lynn Yamout and Zidi Lyu. @NSERC_PROMOTE is excited to work with you! @NSERC_CRSNG @DamhaLab @nic_moitessier
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Another fantastic GWB-2024! Thanks to all our guests, sponsors and excellent trainee leaders. #GWB2024, @NSERC_CRSNG, @McGillChemistry @McGillCGSS
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Replying to @DamhaLab
@Damhalab presents their lab training module - Studying Oligonucleotide Duplex Stability Using Thermal Denaturation youtube.com/watch?v=IztNioe7… Thanks @Halle, @Zidi, @Nserc
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The First FDA Approval for a GalNAc-conjugated ASO ⬇️ oligotherapeutics.org/the-fi… #ots #oligotherapeutics #oligonucleotide #biotech #science #research #currentscience #attramyloidiosis #fda #fdaapproved #GalNAc #amlyoidosis #wainua #amyloidosistreatment #hATTR #pharmaceuticals

The First FDA Approval for a GalNAc-conjugated ASO - Oligonucleotide Therapeutics Society

It starts with a pins-and-needle sensation in your feet, or maybe your gastrointestinal tract has become easily irritated, or you've started to lose weight or develop heart problems. Hereditary ATTR...

oligotherapeutics.org
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AnnemiekeAartsma-Rus@oligogirl28 Nov 2023
Collaborative paper with @F_ANAtico @DANorDNA and Sarah Engelbeen out now in @OTSociety @LiebertPub journal Nucleic Acid Therapeutics. On optimizing ASOs for exon skipping and RT-PCR to reduce artifacts liebertpub.com/doi/10.1089/n…

Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Mod...

Antisense oligonucleotide (AON)-mediated exon skipping is a promising therapeutic approach for Duchenne muscular dystrophy (DMD) patients to restore dystrophin ...

journals.sagepub.com
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Save the Date! Join us for the 20th Annual Meeting of the Oligonucleotide Therapeutics Society! 🗓 October 6-9, 2024 📍Montreal, Canada oligotherapeutics.org/2024-a… #ots24 #oligomeeting #oligotherapeutics #oligonucleotide #OTS #careers #biotech #science #research #montreal
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Masad J. Damha@F_ANAtico22 Oct 2023
The traditional premeeting LUMC-McGill exchange tradition #OTS23 @OTSociety ⁦@mcgillu⁩ with ⁦@oligogirl⁩
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Masad J. Damha@F_ANAtico24 Sep 2023
Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase academic.oup.com/nar/article… Big thanks to @Roberto_Khoury @Hala_AbouAssi @aaronlavelmoye, Morgane Roman, @Bryan_lab_CMRI @DamhaLab who made this study possible!

Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase

Abstract. Telomeric C-rich repeated DNA sequences fold into tetrahelical i-motif structures in vitro at acidic pH. While studies have suggested that i-moti

academic.oup.com
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Masad J. Damha@F_ANAtico8 Jul 2023
Summer brunch in the Old Port with ⁦@DamhaLab⁩ members - 2023
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Masad J. Damha@F_ANAtico8 Jun 2023
Halle Barber ⁦@McGillChemistry⁩ pressing her work on Gene 🧬 editing with CRISPR Cas12a systems - how much chemical modifications can we introduce in gRNA? ⁦@DamhaLab⁩
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Masad J. Damha@F_ANAtico9 Jun 2023
⁦@AliciaMontulet⁩ is developing exon skipping ASOs for Duchenne Muscular Dystrophy ⁦@McGillChemistry⁩
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Masad J. Damha@F_ANAtico8 Jun 2023
Dr. David Sabatino (Carleton U) & Dr. Jeremy Lackey (Twist Bioscience) attending the CSC 2023 Vancouver Conference ⁦@TwistBioscience⁩ - great ⁦@McGillChemistry⁩ alumni ⁦@DamhaLab⁩
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Masad J. Damha@F_ANAtico5 Jun 2023
Julian Marlyn explaining that high speed mixing (with no or small amounts of solvents) can yield nucleoside monomers and dimer blocks for RNA synthesis at CSC Vancouver conference. @ACSGreenTeam @McGillMSSI @NSERC_CRSNG ⁦⁦@DamhaLab⁩
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Roberto El Khoury@Roberto_Khoury17 Mar 2023
It’s no secret that we @DamhaLab love FANA. Check out this book chapter I co-authored with @F_ANAtico and @migaravis on the wonders of FANA in the context of noncanonical nucleic acids! Special thanks @cgiba87 & his lab for our FANAtastic collaborations! link.springer.com/referencew… – at Montréal, Québec

The Effects of FANA Modifications on Non-canonical Nucleic Acid Struct

Initially explored for its antiviral applications, the 2′-deoxy-2′-fluoroarabino nucleoside is now widely incorporated into oligonucleotides for applications in structure elucidation, synthetic...

link.springer.com
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Chemical Communications@ChemCommun29 Mar 2023
Stay up to date with the latest research like 'End-ligation can dramatically stabilize i-motifs at neutral pH' by @Roberto_Khoury & @F_ANAtico. @DamhaLab Linked below ⬇ rsc.li/3JUvqDU
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Missed our latest webinar with @JamesDThorpe? Don’t worry, you can now view it on-demand at your convenience! Simply click on the link below to access the webinar and discover the latest breakthroughs in this cutting-edge field. oligotherapeutics.org/toward… #OTS #webinar

Towards Developing Greener Methods for Oligonucleotide Synthesis - Oligonucleotide Therapeutics...

Time: 5pm Amsterdam - 9 AM MST Date: February 23, 2023 Research: My research focuses on the development of novel methodologies for oligonucleotide synthesis, with a particular emphasis on reducing...

oligotherapeutics.org
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