Group Leader, University of Minnesota Genomics Center Innovation Lab. Founder, CoreBiome (now Diversigen).
Minneapolis, MN
Joined May 2015
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Daryl Gohl retweeted
We are excited to announce that Objective Biotechnology has received an @NIH SBIR Phase II award to advance the Autoinjector automated microinjection platform!
Daryl Gohl retweeted
READ: “High-throughput genetic manipulation of multicellular organisms using a machine-vision guided embryonic microinjection robot.” Alegria et al. @NSF (ORIP support through 1R21OD028214, 1R24OD028444)
academic.oup.com/genetics/ar…
ALT Issue Cover: April 2024
Daryl Gohl retweeted
New paper in our lab led by Andrew Alegria and @Amey__Joshi published in @GeneticsGSA . Fun collab with @DarylGohl and Bischof group @umnme @UMNCSE We also made it to the cover! academic.oup.com/genetics/ar…
Daryl Gohl retweeted
On the cover of the April issue of GENETICS: An automated microinjection of Drosophila embryos by a computer vision-guided robot. Alegria et al. present a machine vision guided generalized robot that automates the process of microinjection in fruit fly and zebrafish embryos.
🧵⬇️
ALT Automated microinjection of Drosophila embryos by a computer vision-guided robot.
Daryl Gohl retweeted
🚨 New pre-print alert!🚨 Led by the brilliant, twitter-less post-doc James Hope. We built a 🤖 exoskeleton for 🐭🐁 so we can study their 🧠's as they go around navigating their world. An e.g., imaging 1000s of neurons in the cortex when mice walk an 8-maze. A 🧵
Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton biorxiv.org/cgi/content/shor… #bioRxiv
Daryl Gohl retweeted
I am really excited to share that our new pre-print on “A machine vision guided robot for fully automated embryonic microinjection” is out. Thanks to @AndrewAlegria37, all collaborators and @bksuhasa @DarylGohl
🚨🚨 New pre-print alert! A fun collaboration involving 🤖s, fruit🪰s,🐠, and 🧬 with @DarylGohl. Co-led by twitterless Andrew Alegria and @Amey__Joshi . A generalized machine vision guided robot for microinjections into whole intact embryos. biorxiv.org/content/10.1101/… (1/n)
Really excited to share this new preprint on automated microinjection of Drosophila and zebrafish embryos! See this thread by our collaborator @bksuhasa
🚨🚨 New pre-print alert! A fun collaboration involving 🤖s, fruit🪰s,🐠, and 🧬 with @DarylGohl. Co-led by twitterless Andrew Alegria and @Amey__Joshi . A generalized machine vision guided robot for microinjections into whole intact embryos. biorxiv.org/content/10.1101/… (1/n)
We also trained a separate machine learning model and used the same robot to successfully inject zebrafish embryos and believe that this robotic system can be readily generalized to carry out automated microinjection in many other species. (9/10)
This work was led by two amazing grad students, @Amey__Joshi and @AndrewAlegria37, with critical contributions from @sciberius and Jorge Blanco Mendana (not on Twitter). Many thanks to all our co-authors! (10/10)
Daryl Gohl retweeted
New paper! It’s absolutely wild what you see when studying bacteria using single-cell RNA-Seq! Unlike in eukaryotes, we found a genome-scale pattern of correlations among genes showing a strong dependency on global chromosomal locations.
biorxiv.org/content/10.1101/… @AndrewPountain
Daryl Gohl retweeted
What if you could image 🔬cells and then choose which ones to sequence 🧬?
What if you could go back and image 🔬cells that you previously sequenced 🧬?
Now you can 🔬 then 🧬 then 🔬 cells again with Light-Seq!
nature.com/articles/s41592-0…
Let’s dig in 🧵.
Daryl Gohl retweeted
Our ADAR-based RNA sensors just came online! rdcu.be/cWX7o It allows you to express protein payloads in live cells in direct response to the presence of specific RNA transcripts. Also @EerikKaseniit, welcome to twitter.
As we work towards DNA-free circuits, we realized we could use some new RNA sensors in living cells. So we built RADAR biorxiv.org/content/10.1101/… Congrats to Eerik, @katznoa1, @NatalieSKolber, @claytoncalli, and thanks to our plant biologist neighbors, Diego, Will, and @Sattely_lab